Role of error-prone DNA polymerases in spontaneous mutagenesis in Caulobacter crescentus

Valencia, Alexy Orozco; Braz, Vânia Santos; Magalhães, Mauro Taveira; Galhardo, Rodrigo S.

doi:10.1590/1678-4685-gmb-2018-0283

Cited by 10 publications

(3 citation statements)

References 47 publications

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“…Later, a role for imuABC -like cassettes in damage-inducible mutagenesis and DNA damage tolerance was confirmed in other bacterial species ( Koorits et al, 2007 ; Zeng et al, 2011 ; Blanchard and Groot, 2021 ; Sheng et al, 2021 ). In contrast to its role in TLS, involvement of ImuC in spontaneous mutagenesis in C. crescentus is minor ( Valencia et al, 2020 ), and not enhanced by a constitutively transcribed imuABC operon ( Alves et al, 2017 ). More recently it has been shown that non-dividing C. crescentus cells employ ImuC in DNA synthesis during gap filling of nucleotide excision repair intermediates ( Joseph et al, 2021 ).…”

Section: Translesion Synthesis Mutagenesis and Bacterial Evolutionmentioning

confidence: 99%

Sending out an SOS - the bacterial DNA damage response

et al. 2022

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The term "SOS response" was first coined by Radman in 1974, in an intellectual effort to put together the data suggestive of a concerted gene expression program in cells undergoing DNA damage. A large amount of information about this cellular response has been collected over the following decades. In this review, we will focus on a few of the relevant aspects about the SOS response: its mechanism of control and the stressors which activate it, the diversity of regulated genes in different species, its role in mutagenesis and evolution including the development of antimicrobial resistance, and its relationship with mobile genetic elements.

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Section: Translesion Synthesis Mutagenesis and Bacterial Evolutionmentioning

confidence: 99%

Sending out an SOS - the bacterial DNA damage response

et al. 2022

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“…These results contrast with previous results that showed that AT->GC mutations were the most common types of mutations in C . vibrioides [ 28 , 29 ]. However, in these previous studies, the number of mutations was both small and limited by selection for a particular phenotype (rifampicin resistance or inactivation of the XylR repressor).…”

Section: Resultsmentioning

confidence: 99%

Genomic GC content drifts downward in most bacterial genomes

Ely

2021

PLoS ONE

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In every kingdom of life, GC->AT transitions occur more frequently than any other type of mutation due to the spontaneous deamination of cytidine. In eukaryotic genomes, this slow loss of GC base pairs is counteracted by biased gene conversion which increases genomic GC content as part of the recombination process. However, this type of biased gene conversion has not been observed in bacterial genomes, so we hypothesized that GC->AT transitions cause a reduction of genomic GC content in prokaryotic genomes on an evolutionary time scale. To test this hypothesis, we used a phylogenetic approach to analyze triplets of closely related genomes representing a wide range of the bacterial kingdom. The resulting data indicate that genomic GC content is drifting downward in bacterial genomes where GC base pairs comprise 40% or more of the total genome. In contrast, genomes containing less than 40% GC base pairs have fewer opportunities for GC->AT transitions to occur so genomic GC content is relatively stable or actually increasing. It should be noted that this observed change in genomic GC content is the net change in shared parts of the genome and does not apply to parts of the genome that have been lost or acquired since the genomes being compared shared common ancestor. However, a more detailed analysis of two Caulobacter genomes revealed that the acquisition of mobile elements by the two genomes actually reduced the total genomic GC content as well.

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“…Posteriormente, uma função para operons com estrutura imuABC na mutagênese induzida por dano e tolerância a danos no DNA foi comprovado em outras espécies bacterianas. Em contraste com seu papel na TLS, o envolvimento de ImuC na mutagênese espontânea em C. crescentus é pequeno, e não é aumentado por uma transcrição constitutiva operon imuABC (ALVES et al, 2017;BLANCHARD;DE GROOT, 2021;GALHARDO et al, 2005;KOORITS et al, 2007;SHENG et al, 2021;VALENCIA et al, 2020;ZENG et al, 2011). ALVES et al, 2017;GALHARDO et al, 2005;TIMINSKAS et al, 2014;WARNER et al, 2010).…”

Section: A Resposta Sos E Os Mecanismos De Mutagêneseunclassified

Estudos da indução da resposta SOS por ciprofloxacina em >i<Pseudomonas aeruginosa>/i<

Noronha

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Role of error-prone DNA polymerases in spontaneous mutagenesis in Caulobacter crescentus

Cited by 10 publications

References 47 publications

Sending out an SOS - the bacterial DNA damage response

Sending out an SOS - the bacterial DNA damage response

Genomic GC content drifts downward in most bacterial genomes

Estudos da indução da resposta SOS por ciprofloxacina em >i<Pseudomonas aeruginosa>/i<

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