VDR polymorphisms influence immunological response in HIV-1+ individuals undergoing antiretroviral therapy

Silva, Ronaldo Celerino da; Alves, Neyla Maria Pereira; Pereira, Jorge José de Souza; Coelho, Antônio Victor Campos; Arraes, Luiz Cláudio; Brandão, Lucas André Cavalcanti; Crovella, Sérgio; Silva, Jaqueline de Azevêdo

doi:10.1590/1678-4685-gmb-2017-0289

Cited by 3 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…VitD receptors (VDR) are known to be expressed on human T cells, and they play a role in T cell activation [40]. Heterogeneity in VitD responses may be due to VDR polymorphisms [41][42][43]. VitD therapy has been attempted for certain autoimmune diseases [44][45][46], based on results in animal models showing that VitD can PLOS ONE increase the ratio of Treg to Th17 cells [47,48].…”

Section: Discussionmentioning

confidence: 99%

Arsenic exposure associated T cell proliferation, smoking, and vitamin D in Bangladeshi men and women

et al. 2020

View full text Add to dashboard Cite

There are limited data examining the consequences of environmental exposure to arsenic on the immune system in adults, particularly among smokers. Smoking has been shown to exacerbate or contribute to impaired immune function in men chronically exposed to arsenic. In contrast, vitamin D (VitD) is known to have a positive influence on innate and adaptive immune responses. The effect of circulating VitD on arsenic-associated immune dysfunction is not known. Here we examine the relationship of arsenic exposure and T cell proliferation (TCP), a measure of immune responsiveness, and circulating VitD among adult men and women in Bangladesh. Arsenic exposure was assessed using total urinary arsenic as well as urinary arsenic metabolites all adjusted for urinary creatinine. TCP was measured ex vivo in cryopreserved peripheral blood mononuclear cells from 614 adult participants enrolled in the Bangladesh Health Effects of Arsenic Longitudinal Study; serum VitD was also evaluated. The influence of cigarette smoking on arsenic-induced TCP modulation was assessed only in males as there was an inadequate number of female smokers. These studies show that arsenic suppressed TCP in males. The association was significantly strong in male smokers and to a lesser extent in male non-smokers. Interestingly, we found a strong protective effect of high/sufficient serum VitD levels on TCP among non-smoking males. Furthermore, among male smokers with low serum VitD (t20 ng/ml), we found a strong suppression of TCP by arsenic. On the other hand, high VitD (>20 ng/ml) was found to attenuate effects of arsenic on TCP among male-smokers. Overall, we found a strong protective effect of VitD, when serum levels were >20 ng/ml, on arsenic-induced inhibition of TCP in men,

show abstract

Section: Discussionmentioning

confidence: 99%

Arsenic exposure associated T cell proliferation, smoking, and vitamin D in Bangladeshi men and women

et al. 2020

View full text Add to dashboard Cite

show abstract

“…exerts an immunomodulatory activity through the vitamin D receptor (VDR) by activating monocytes, stimulating cell-mediated immunity and suppressing lymphocyte proliferation, antibody production, and cytokine synthesis. VDR mediates genomic actions of 1,25 (OH)2D3, by acting as a transcription factor that modulates the expression of several1, 25 [16,17].…”

Section: Introductionmentioning

confidence: 99%

PCR-RFLP of the Vitamin D Receptor Gene in Human Immunodeficiency Virus Patients Deficient in Vitamin D3 in Cote d’Ivoire

Boyvin

Aké

Yayé

et al. 2020

MRJI

View full text Add to dashboard Cite

Aims: This study was to identify mutations in patients’ vitamin D receptor (VDR) gene in Côte d'Ivoire, precisely in Human immunodeficiency virus (HIV) patients deficient in vitamin D3. Methodology: Fifty (50) DNA extractions from peripheral blood mononuclear cells collected from HIV positive and vitamin D3 deficient patients were analyzed after verifying their integrity by quantification of genomic DNA and migration from agarose gel. The use of the restriction enzymes Dpn I, Bg III and Pst I made it possible to carry out the PCR-RLFP of the fragments Fok-1 in exon 2, Bsm-1 and Apa-1 in intron 8 and Taq-1 in exon 9. Results: The analysis of the DNA fragments Fok-1 in exon 2 and Bsm-1 in intron 8 of the VDR gene from HIV positive patients deficient in vitamin D3 showed a significantly high prevalence of mutant genotype (100% and 98%) respectively p = 0.0001. Furthermore, in this study, a prevalence of 6% of mutant genotype was observed in Taq-1 of exon 9 of the VDR gene. Conclusion: The high prevalence of mutant genotypes observed in the DNA fragments of Fok-1 in exon 2 and Bsm-1 in intron 8 of the VDR gene studied confirms the presence of mutations in the VDR gene of these patients. It would, therefore, be necessary to sequence the DNA fragments with mutations in order to identify the mutations that affect the VDR gene and that are responsible for the vitamin D3 deficiency observed in these patients.

show abstract

Host Genetic Impact on Infectious Diseases among Different Ethnic Groups

Naidoo,

Arumugam,

Ramsuran

2023

Advanced Genetics

View full text Add to dashboard Cite

Infectious diseases such as malaria, tuberculosis (TB), human immunodeficiency virus (HIV), and the coronavirus disease of 2019 (COVID‐19) are problematic globally, with high prevalence particularly in Africa, attributing to most of the death rates. There have been immense efforts toward developing effective preventative and therapeutic strategies for these pathogens globally, however, some remain uncured. Disease susceptibility and progression for malaria, TB, HIV, and COVID‐19 vary among individuals and are attributed to precautionary measures, environment, host, and pathogen genetics. While studying individuals with similar attributes, it is suggested that host genetics contributes to most of an individual's susceptibility to disease. Several host genes are identified to associate with these pathogens. Interestingly, many of these genes and polymorphisms are common across diseases. This paper analyzes genes and genetic variations within host genes associated with HIV, TB, malaria, and COVID‐19 among different ethnic groups. The differences in host–pathogen interaction among these groups, particularly of Caucasian and African descent, and which gene polymorphisms are prevalent in an African population that possesses protection or risk to disease are reviewed. The information in this review could potentially help develop personalized treatment that could effectively combat the high disease burden in Africa.

show abstract

VDR polymorphisms influence immunological response in HIV-1+ individuals undergoing antiretroviral therapy

Cited by 3 publications

References 29 publications

Arsenic exposure associated T cell proliferation, smoking, and vitamin D in Bangladeshi men and women

Arsenic exposure associated T cell proliferation, smoking, and vitamin D in Bangladeshi men and women

PCR-RFLP of the Vitamin D Receptor Gene in Human Immunodeficiency Virus Patients Deficient in Vitamin D3 in Cote d’Ivoire

Host Genetic Impact on Infectious Diseases among Different Ethnic Groups

Contact Info

Product

Resources

About