Genetic variations in circadian rhythm genes and susceptibility for myocardial infarction

Abstract

Disruption of endogenous circadian rhythms has been shown to increase the risk of developing myocardial infarction (MI), suggesting that circadian genes might play a role in determining disease susceptibility. We conducted a case-control study on 200 patients hospitalized due to MI and 200 healthy controls, investigating the association between MI and single nucleotide polymorphisms (SNPs) in four circadian genes (ARNTL, CLOCK, CRY2, and PER2). The variants of all four genes were chosen based on their previously reported association with cardiovascular risk factors, which have a major influence on the occurrence of myocardial infarction. Statistically significant differences, assessed through Chi-square analysis, were found in genotype distribution between cases and controls of the PER2 gene rs35333999 (p=0.024) and the CRY2 gene rs2292912 (p=0.028); the corresponding unadjusted odds ratios, also significant, were respectively OR=0.49 (95% CI 0.26-0.91) and OR=0.32 (95% CI 0.11-0.89). Our data suggest that genetic variability in the CRY2 and PER2 genes might be associated with myocardial infarction.

The Impact of the Circadian Genes CLOCK and ARNTL on Myocardial Infarction

“…This research is a continuation of the preliminary study from 2018 [29]. The present study was aimed at searching for a potential correlation between the SNPs of the CLOCK, ARNTL, and PER2 genes in patients with myocardial infarction.…”

“…The data presented here were collected as part of previously reported studies on circadian rhythm variations in patients with myocardial infarction [25,29,30]. The sample included 431 patients (243 males, 188 females) of Croatian origin with non-fatal acute myocardial infarction at the Clinical Department of Cardiovascular Diseases and Intensive Care at the University Hospital Osijek, from August 2012 to December 2018.…”

Circadian rhythm and myocardial infarction

“…Različite varijacije gena cirkadijalnog ritma povezane su s mnogim čimbenicima rizika za kardiovaskularne bolesti. Tako su varijacije gena CLOCK povezane s metaboličkim sindromom u ljudi, razvojem dijabetesa tipa 2, a neke i s nastankom moždanog udara 66,[68][69][70] , dok su varijacije gena CRY2 i PER2 povezane s infarktom miokarda 71 . Izražajnost gena CRY1 i PER2 u masnom tkivu povezana je s metaboličkim sindromom u ljudi 66,72 .…”

Myocardial Infarction and Circadian Rhythm

“…Different variations of circadian rhythm genes are associated with many risk factors for cardiovascular disease. Thus, CLOCK gene variations are associated with metabolic syndrome in humans, type 2 diabetes, and some with stroke [64,[66][67][68], while CRY2 and PER2 gene variations are associated with myocardial infarction [69]. Expression of CRY1 and PER2 genes in fatty tissue is associated with metabolic syndrome in humans [64,70].…”