Adiponectin promoter polymorphisms are predictors of lipid profile improvement after bariatric surgery

Gasparotto, Aline; Borges, Diego Olschowsky; Zandoná, Marília Remuzzi; Ramos, Mauricio Jacques; Meihnardt, Nelson Guardiola; Mattevi, Vanessa Suñé

doi:10.1590/1678-4685-gmb-2016-0241

Cited by 14 publications

(8 citation statements)

References 33 publications

(40 reference statements)

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“…Follow‐up ranged from 6 months to 5 years. Changes in frequency of obesity‐related metabolic problems were reported in 18 studies, 32,40,47–60,68,72 and fasting glucose, HOMA IR, HbA1c, and/or lipids were reported in 21 studies 27,29,47–60,68,69,74–76 . One study used diabetes remission, defined as cessation of antidiabetic therapies, as outcome 34 .…”

Section: Resultsmentioning

confidence: 99%

Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review

van der Meer,

Mohamed,

Monpellier

et al. 2023

Obesity Reviews

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SummaryThe extent to which genetic variations contribute to interindividual differences in weight loss and metabolic outcomes after bariatric surgery is unknown. Identifying genetic variants that impact surgery outcomes may contribute to clinical decision making. This review evaluates current evidence addressing the association of genetic variants with weight loss and changes in metabolic parameters after bariatric surgery. A search was conducted using Medline, Embase, Scopus, Web of Science, and Cochrane Library. Fifty‐two eligible studies were identified. Single nucleotide polymorphisms (SNPs) at ADIPOQ (rs226729, rs1501299, rs3774261, and rs17300539) showed a positive association with postoperative change in measures of glucose homeostasis and lipid profiles (n = 4), but not with weight loss after surgery (n = 6). SNPs at FTO (rs11075986, rs16952482, rs8050136, rs9939609, rs9930506, and rs16945088) (n = 10) and MC4R (rs11152213, rs476828, rs2229616, rs9947255, rs17773430, rs5282087, and rs17782313) (n = 9) were inconsistently associated with weight loss and metabolic improvement. Four studies examining the UCP2 SNP rs660339 reported associations with postsurgical weight loss. In summary, there is limited evidence supporting a role for specific genetic variants in surgical outcomes after bariatric surgery. Most studies have adopted a candidate gene approach, limiting the scope for discovery, suggesting that the absence of compelling evidence is not evidence of absence.

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Section: Resultsmentioning

confidence: 99%

Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review

van der Meer,

Mohamed,

Monpellier

et al. 2023

Obesity Reviews

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“…All parameters showed the same improvement after a diet high in polyunsaturated fat [ 17 ]. One interventional study of 60 severely obese patients evaluated 32 months after bariatric surgery revealed that C-allele homozygotes decreased BMI and the lipid profile in obese people [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Adiponectin Gene Polymorphisms and Possible Susceptibility to Metabolic Syndrome among the Sudanese Population: A Case-Control Study

Mosad

Elfadil

Gassoum

et al. 2023

International Journal of Endocrinology

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Background and Aim. The adiponectin gene (ADIPQ) has been identified as a human adiposity marker of metabolic syndrome (MetS) in several ethnic cultures. This study aimed to determine the allelic genotypes and haplotypes distribution of the ADIPQ gene polymorphisms and its association with body mass index (BMI), waist circumference (WC), glycated hemoglobin (HbA1c), and lipid profile in MetS adult Sudanese patients. Methodology. Four hundred and twenty middle-aged adults participated in this community-based case-control research. BMI (kg/m2) and blood pressure (BP) were measured. HbA1c (%) and lipid profile evaluation was performed on fasting blood samples. The guanidine extraction procedure was used to extract genomic DNA from EDTA whole blood by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP); samples were genotyped for the polymorphisms (rs266729), (rs2241766), and (rs1501299). Results. There is a significant difference in genotypic frequencies of the rs266729, rs2241766, and rs1501299 SNPs and allele frequencies P < 0.05 between the MetS patients and non-MetS group. MetS patients had a significantly higher serum triglycerides (TG), total cholesterol (TC), and low-density lipoprotein-cholesterol (LDL-C) in the GG genotype of rs2241766 P < 0.05 . Additionally; the TT genotype of rs1501299 had higher SBP, serum TG, TC, and LDL-C P < 0.05 . Multivariate logistic regression analysis showed hypertension, hyperglycemia, BMI, WC, serum TG, ADIPOQ rs2241766 (TG allele), and ADIPOQ rs1501299 (GT allele) had independently predicted the incidence of metabolic syndrome in the Sudanese population. The three investigated SNPs of ADIPOQ were in a moderate linkage disequilibrium (LD) connection according to the LD measures (D' = 0.54, 0.62, and 0.69, respectively). The CTT, CGG, and GTG haplotypes, which consist of three alleles of −11377C > G, +45T > G, and +276G > T, were shown to report 1.788-, 1.622,- and 1.641-fold risks toward MetS susceptibility in Sudanese’s population, respectively. Conclusion. Along with clinical and biochemical signs, the ADIPOQ gene’s genetic variants (rs266729, rs2241766, and rs1501299), CTT, CGG, and GTG haplotypes are connected to the MetS risk among the Sudanese population.

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“…Our study did not show an effect of rs3774261 on weight loss, but we did find an effect on the modification of the lipid profile. Another interventional study with this SNP rs266729 was conducted in patients after bariatric surgery (Roux Y gastroenterostomy) [30]. Individuals with the C allele were more prone to showing a reduction of LDL cholesterol levels after bariatric surgery (i.e., -43 vs. -18%) compared to G-allele carriers.…”

Section: Discussionmentioning

confidence: 99%

Serum Lipid and Adiponectin Improvements after a Mediterranean Dietary Pattern in Non-G-Allele Carriers of the Variant rs3774261

Luis¹,

Primo²,

Izaola³

et al. 2020

Lifestyle Genomics

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Background: The role of adiponectin (ADIPOQ) polymorphisms in weight loss and serum lipid changes following different dietary interventions remain unclear. The Mediterranean dietary pattern has been associated with improved cardiovascular risk factors in different studies. Objective: Our aim was to analyze the effects of a hypocaloric diet with a Mediterranean dietary pattern on the metabolic response and adiposity parameters, taking into account the 712 G/A rs3774261 polymorphisms in ADIPOQ. Design: A population of 135 obese patients was enrolled. Anthropometric and serum parameters (lipid profile, insulin, homeostasis model assessment for insulin resistance [HOMA-IR], glucose, C-reactive protein [CRP], adiponectin, resistin, and leptin levels) were measured before and after the dietary intervention (12 weeks). All of the patients were genotyped for the rs3774261 polymorphism. Results: The genotype distribution of this population was 36 patients with AA (26.7%), 68 patients with AG (50.4%), and 31 patients with GG (22.9%). After the dietary intervention and in both genotypes, BMI, weight, fat mass, systolic blood pressure, waist circumference, glucose, insulin, HOMA-IR, and leptin levels all decreased. After the dietary intervention with secondary weight loss and in non-G-allele carriers (AA vs. AG+GG), total cholesterol (Δ = –15.7 ± 3.9 vs. –4.9 ± 2.9 mg/dL; p = 0.02), LDL cholesterol (Δ = –15.3 ± 3.8 vs. –1.7 ± 1.9 mg/dL; p = 0.01), triglyceride levels (Δ = –23.4 ± 5.6 vs. 2.3 ± 2.3 mg/dL; p = 0.01), and CRP (Δ = –1.1 ± 0.1 vs. –0.4 ± 0.2 mg/dL; p = 0.01) decreased. Adiponectin levels (Δ = 7.2 ± 2.1 vs. –0.4 ± 0.3 ng/dL; p = 0.02) increased. Notably, G-allele carriers did not show this improvement. Conclusion: Non-G-allele carriers of the ADIPOQ variant (rs3774261) showed significant improvement in serum levels of adiponectin, lipid profiles, and CRP in response to a hypocaloric diet with a Mediterranean dietary pattern.

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Adiponectin promoter polymorphisms are predictors of lipid profile improvement after bariatric surgery

Cited by 14 publications

References 33 publications

Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review

Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review

Adiponectin Gene Polymorphisms and Possible Susceptibility to Metabolic Syndrome among the Sudanese Population: A Case-Control Study

Serum Lipid and Adiponectin Improvements after a Mediterranean Dietary Pattern in Non-G-Allele Carriers of the Variant rs3774261

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