Abstract:The identification of antitumoral substances is the focus of intense biomedical
research. Two structural analogues of thalidomide, LNO3 and L3, are two synthetic
compounds that might possess such antitumor properties. We evaluated the
toxicological effects of these substances, including cytotoxicity, genotoxicity and
induction of apoptosis in HTC cells. Additionally, the production of free radicals
(nitric oxide and superoxide) was investigated, and the expression of caspases genes
3, 8, and 9 were determined … Show more
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