Antigenotoxicity and antimutagenicity of ethanolic extracts of Brazilian green propolis and its main botanical source determined by the Allium cepa test system

Roberto, Matheus Mantuanelli; Jamal, Cláudia Masrouah; Malaspina, Osmar; Marin-Morales, Maria Aparecida

doi:10.1590/1678-4685-gmb-2015-0130

Cited by 21 publications

(7 citation statements)

References 51 publications

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“…The Allium cepa L. test system is widely used for evaluating the cytogenotoxic potential of infusions made with medicinal plants (Bagatini et al 2007). Some studies point to a high concordance between this vegetal and mammal systems (Bagatini et al, 2007, Sturbelle et al 2010, Fedel-Miyasato et al 2014, Roberto et al 2016. Besides that, it is a low cost and easyhandling assay (Leme and Marin-Morales 2009), which allow to expose the test organism directly to complex mixtures without previous treatment of the test sample (Rank and Nielsen 1993).…”

Section: Introductionmentioning

confidence: 96%

In vivo assessment of cyto/genotoxic, antigenotoxic and antifungal potential of Costus spiralis (Jacq.) Roscoe leaves and stems

Sousa

Paz

Rocha

et al. 2018

An. Acad. Bras. Ciênc.

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Costus spiralis is a Brazilian native plant used in popular medicine, but the safety of this therapeutic use needs investigation. So, the aim of this study was to evaluate the cytogenotoxic and antigenotoxic effects of C. spiralis leaves or stems aqueous extracts on Allium cepa root cells. Moreover, a phytochemical screening and an antioxidant and antifungal activities evaluation were performed. C. spiralis aqueous extracts presented cytotoxicity, but no mutagenicity was observed. When the antigenotoxicity was evaluated, C. spiralis leaves aqueous extract presented preventive and modulatory effects on A. cepa root cells, reducing the sodium azide cytogenotoxic effects. In contrast, C. spiralis stems aqueous extract enhanced the sodium azide cytogenotoxicity in some conditions. The phytochemical screening revealed the presence of phenolic compounds in C. spiralis. When total phenolic content was determined, the leaves presented 73% more phenolic content than stems. Corroborating this data, C. spiralis leaves antioxidant potential was 30% higher than C. spiralis stems. However, these extracts did not present antifungal activity against Candida spp. In conclusion, empirical utilization of C. spiralis aqueous extracts should be avoided. Moreover, the cytotoxic effect of C. spiralis leaves and stems can play an important role in anticancer therapy and must be deeply studied.

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Section: Introductionmentioning

confidence: 96%

In vivo assessment of cyto/genotoxic, antigenotoxic and antifungal potential of Costus spiralis (Jacq.) Roscoe leaves and stems

Sousa

Paz

Rocha

et al. 2018

An. Acad. Bras. Ciênc.

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“…Propolis therapy has been considered to be a safe alternative treatment. No toxic effects of green propolis ethanolic extracts, such as mutagenic activity, histopathological changes in long‐time use, and genotoxic potential were observed until now. However, more studies with different cell types are needed to ensure that the in vivo administration of propolis would not cause toxic effects in different body tissues.…”

Section: Biological Activitiesmentioning

confidence: 95%

Propolis: types, composition, biological activities, and veterinary product patent prospecting

et al. 2019

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Propolis is a resinous substance composed of a mixture of different plant parts and molecules secreted by bees. Chemically, it is defined as a complex matrix containing biologically active molecules with antibacterial, antifungal, antiviral, antiparasitic, hepatoprotective, and immunomodulatory activities. It is widely employed in cosmetic formulations and pharmaceutical products and is one of the most widely used natural products. However, the effects and strength of these biological activities depend on the chemical profile and composition of each propolis type. This composition is associated with the diversity of local flora, the place and period of collection, and the genetics of the bees. In this context, the objective of this review was to investigate the biological, chemical, and microbiological properties of propolis. A technological prospection was also performed on patents for products designed to be used in animal health. Our investigation shows that the literature contains diverse studies dedicated to comparing and describing the composition and therapeutic properties of propolis. These studies demonstrate the potential biological use of propolis in veterinary medicine, showing the applications of propolis extracts in different formulations. However, there are a low number of propolis‐based veterinary products with a registered patent. Thus, the development of products based on propolis is a promising market to be exploited. © 2019 Society of Chemical Industry

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“…As one of the world-famous propolis type, Brazilian green propolis displays as green since it especially comes from Baccharis dracunculifolia, a plant resource widely distributed in South America [2][3][4] . Brazilian green propolis contains a variety of chemical components and is reported to have multiple biomedical activities, such as antibacterial activities, antioxidant, antiulcer, antiinflammatory, antigenotoxicity and antimutagenicity [5][6][7][8][9] etc.…”

Section: Unique Dynamic Mode Between Artepillin C and Human Serum Albmentioning

confidence: 99%

Unique dynamic mode between Artepillin C and human serum albumin implies the characteristics of Brazilian green propolis representative bioactive component

Song

Qiu

et al. 2020

Sci Rep

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As a representative bioactive component in Brazil green propolis, Artepillin C (ArtC; 3, 5-diprenyl-4-hydroxycinnamic acid) has been reported a wide variety of physiological activities including anti-tumor, anti-inflammatory, and antimicrobial activity etc. However, it seems incompatible that ArtC in vivo was characterized as low absorption efficiency and low bioavailability. In order to obtain the elucidation, we further investigated the physicochemical basis of ArtC interacting with human serum albumin (HSA) in vitro. We found a unique dynamic mode interaction between ArtC and HSA, which is completely different from other reported propolis bioactive components. Thermodynamic analysis showed that hydrophobic interactions and electrostatic forces are the main driving force. The competitive assay indicates that the binding site of ArtC with HSA is close to the Sudlow’s site I. The findings of this study reveal the unique physicochemical transport mechanism of ArtC in the human body, which helps to further understand the uniqueness of the representative functional components of Brazilian green propolis in the human body.

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Antigenotoxicity and antimutagenicity of ethanolic extracts of Brazilian green propolis and its main botanical source determined by the Allium cepa test system

Cited by 21 publications

References 51 publications

In vivo assessment of cyto/genotoxic, antigenotoxic and antifungal potential of Costus spiralis (Jacq.) Roscoe leaves and stems

In vivo assessment of cyto/genotoxic, antigenotoxic and antifungal potential of Costus spiralis (Jacq.) Roscoe leaves and stems

Propolis: types, composition, biological activities, and veterinary product patent prospecting

Unique dynamic mode between Artepillin C and human serum albumin implies the characteristics of Brazilian green propolis representative bioactive component

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