Development of Facial Cosmetic Formulations Using Microbial Levan in Association with Plant-Derived Compounds Using Simple Lattice Design

Abstract

The cosmetics industry searches for new products with sustainable, natural and non-toxic characteristics. Levan is a microbial exopolysaccharide composed of fructose units with β-2,6-glycoside bonds. Due to its biological properties, levan has a wide range of applications in cosmetics and pharmaceuticals industry. The effects of levan can be improved by its combination with biocompatible actives such as plant-derived compounds and vitamins resulting in a multifunctional cosmetic formulation. Thus, the aim of this study was to develop a new biocosmetic gel-anionic type containing 1 % of levan and plant-derived compounds, such as Aloe vera extract and avocado oil and vitamin E, using simplex lattice mixtures design. According to the statistical analyses, the concentrations to obtain a cosmetic with maximum antioxidant activity (76%), hydration capacity (98.37%) and spreadability (767.30 mm²), would be 10% (0.1 mL) of Aloe vera, and 90% (0.9 mL) of avocado oil. Cosmeceutical formulations showed good stability and did not show phase separation or visible changes being classified as normal. The development of innovative and HIGHLIGHTS• A levan-based formulation composed of Aloe vera and avocado oil was development.• Biocosmetic showed antioxidant activity, retention capacity and good spreadability.• Levan-based formulation was efficiently modeled within the simplex design space.• Cosmetic formulations showed great stability and pH compatible with skin.

Multifunctional Biotechnological Lip Moisturizer for Lip Repair and Hydration: Development, In Vivo Efficacy Assessment and Sensory Analysis

“…LEV was produced by the enzyme levansucrase, obtained through the bacteria B. subtilis natto (CCT 7712), according to the methodology described by Helenas et al [21]. LEV extraction occurred through precipitation with absolute ethanol in a ratio of 1:3 v/v (supernatant: ethanol), with the system kept at rest for 12 h at 4 • C. Then, centrifugation was used at 6500 G for 20 min and at 4 • C. After complete evaporation of the ethanol, the LEV was dialyzed against distilled water for 48 h, with three daily water changes, and was subsequently frozen and lyophilized.…”

“…They verified that the incorporation of these actives helped to improve all the parameters evaluated (805 mm 2 , 72% and 100.3%, respectively). Helenas et al [21] developed a new biocosmetic gel-anionic type containing LEV, and, using the Simple Lattice Design, they evaluated the optimized formulation, which was composed of LEV (1%), avocado oil (0.9 mL) and aloe vera extract (0.1 mL). According to statistical analyses, this formulation would have good spreadability (767.30 mm 2 ), antioxidant capacity (76%) and moisturizing capacity (98.37%).…”

Incidência De Desordens Temporomandibulares (Dtm) Entre Professores De Música

“…Algumas certificações, como a COSMOS e a Natrue, estabelecem determinações para a identificação e a classificação de matérias-primas e produtos naturais (GIRARDELLO et al, 2021). Dessa forma, estudos recentes sugerem a aplicação de moléculas, como o amido, quitosana, levana, polihidroxialcanoatos (PHA), os soforolipídios e os óleos essenciais na criação de novos cosméticos verdes FILIPE et al, 2021;HELENAS et al, 2023).…”

A dinâmica do conhecimento biomédico

“…Algumas certificações, como a COSMOS e a Natrue, estabelecem determinações para a identificação e a classificação de matérias-primas e produtos naturais (GIRARDELLO et al, 2021). Dessa forma, estudos recentes sugerem a aplicação de moléculas, como o amido, quitosana, levana, polihidroxialcanoatos (PHA), os soforolipídios e os óleos essenciais na criação de novos cosméticos verdes FILIPE et al, 2021;HELENAS et al, 2023).…”