Establishment of Tissue Biodistribution and Blood Clearance Rates of Intravenously Administered Radioactive 51Cr3+ in New Zealand White Rabbits

Abstract

Radioactive trivalent chromium ( 51 Cr 3+ ) is a known radiopharmaceutical used to tag plasma proteins, platelets and also for estimation of blood volume. Nevertheless, there exist insufficient reports with limited sample sizes concerning its clearance from blood and its biodistribution after intravenous administration. This study focused to understand clearance rate of 51 Cr 3+ from blood and analyze its biodistribution. For biodistribution, six adult New Zealand white albino rabbits were injected with 51 Cr 3+ through their marginal vein. Percentage clearance of 51 Cr 3+ from blood was calculated by recording HIGHLIGHTS• Tissue biodistribution of intravenously administered trivalent chromium.• Blood clearance rates of intravenously administered trivalent chromium.• Faster systemic blood clearance is through renal excretion.