In Vitro Enzyme Inhibitory Activity of Ten Ferulago W. Koch Species Growing in Turkey

Akkol, Esra Küpeli; Günbatan, Tuğba; Gürbüz, İlhan; Duman, Hayrí; Kılıç, Ceyda Sibel; İlhan, Mert

doi:10.1590/1678-4324-2022210207

Cited by 3 publications

(3 citation statements)

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“…Furthermore, these species are commonly used as animal fodder to improve animal productivity due to their aphrodisiac effects. 3 In traditional medicine, they have been used in carminative, peptic, sedative, aphrodisiac, vermifuge, immunostimulant, flavor, digestive, tonic, germicidal, and antibronchitis applications, as well as against ulceration, nuisance, snakebite, hemorrhoids, and splenetic illnesses. 4 Coumarins, 5,6 sesquiterpenes, 6 strerol, 7,8 and flavonoids 9,10 have previously been found in Ferulago species.…”

Section: Introductionmentioning

confidence: 99%

“…Thirty-five secondary metabolites have so far been identified. 3,12,13 The plant contains various types of compounds, with coumarins, flavonoids, and phenolic and aromatic acids being the most characteristic components. 12,13 Furthermore, antioxidant, cytotoxicity, alpha-glucosidase, alpha-amylase, tyrosinase, acetylcholinesterase, butyrylcholinesterase enzyme inhibitory activities, 12 and wound healing activity 3,12 have been reported.…”

Section: Introductionmentioning

confidence: 99%

“…3,12,13 The plant contains various types of compounds, with coumarins, flavonoids, and phenolic and aromatic acids being the most characteristic components. 12,13 Furthermore, antioxidant, cytotoxicity, alpha-glucosidase, alpha-amylase, tyrosinase, acetylcholinesterase, butyrylcholinesterase enzyme inhibitory activities, 12 and wound healing activity 3,12 have been reported. Although previous studies assessed several biological activity profiles of FS, there are limited data on the chemical profile, antioxidant, antibacterial activity, antiproliferative, and cytotoxicity properties of FS.…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical analysis and biological evaluation of Ferulago setifolia K. Koch

Gözcü,

Akşit,

Şimşek

et al. 2023

J Sci Food Agric

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BackgroundFerulago setifolia K. Koch (Apiaceae) has been the subject of this study, aiming to comprehensively determine its phenolic fingerprint and evaluate its various biological activities. The LC‐MS/MS analysis of the 70% methanol extract of Ferulago setifolia (FS) has revealed the presence of 23 phytochemicals. Among them, chlorogenic acid, quinic acid, kaempferol‐3‐O‐glucoside, and quercetin‐3‐O‐glucoside were identified as the major phenolics in the extract.ResultsThe biological screening included examinations of antioxidant, antibacterial, antiproliferative, and cytotoxic activities. The FS extract displayed moderate DPPH radical scavenging and ferric‐reducing capacity, indicating moderate antioxidant activity. Furthermore, FS exhibited significant antiproliferative effects on cancer cells while showing low cytotoxicity on normal cells. The antibacterial activity findings revealed that FS demonstrated potent activity against Pseudomonas aeruginosa, Bacillus cereus, Staphylococcus aureus, and Escherichia coli.ConclusionThe findings of this study suggest that the methanolic extract of FS holds promise as a potential source of biologically active compounds. It can be utilized for the development of pharmaceutical formulations, thanks to its significant antiproliferative and antibacterial activities. Additionally, FS can serve as a valuable source of chlorogenic acid for industrial applications.This article is protected by copyright. All rights reserved.

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