Investigation of the Effects of Glutens on Serum Interleukin-1 Beta and Tumor Necrosis Factor-Alpha Levels and the Immunohistochemical Distribution of CD3 and CD8 Receptors in the Small Intestine in Male Rats

Gümüş, Recep; Uslu, Sema; Aydoğdu, Uğur; İmik, Aybüke; Ekici, Mehmet Fati̇h

doi:10.1590/1678-4324-2021210256

Cited by 3 publications

(1 citation statement)

References 26 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, CD4-and CD8immunopositivity levels were found to be higher in the group, which received wheat gluten. Similarly, in a previous study by Gümüş and coauthors [34], it was determined that male rats fed on wheat and corn glutens displayed higher CD8 levels in the small intestine.…”

Section: Discussionmentioning

confidence: 58%

The Effects of Dietary Wheat and Corn Glutens on the Histopathological and Immunohistochemical Structure of the Ovarian Tissue and Serum and Ovarian Tissue LH and FSH Levels and Lipid Profiles in Rats

İmik

Kapakin

Karabulutlu

et al. 2023

Braz. arch. biol. technol.

Self Cite

View full text Add to dashboard Cite

This study was aimed at determining the effects of corn and wheat glutens on the histopathological and immunohistochemical structure of the ovarian tissue, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels, and lipid profile in rats. Twenty-day-old 24 female Sprague-Dawley rats were assigned to three groups, and were raised until 185 days of age. Three study groups, named as Wheat, Corn and Soybean Groups, were established and fed on wheat gluten, corn gluten and soybean meal, respectively, as a protein source. At the end of the trial, ovarian tissue specimens and serum samples were taken from the animals, and analyzed. Compared to Soybean Group, in Wheat Group, of the ovarian histopathological parameters investigated, values pertaining to the primordial, primary, secondary, and Graafian follicles and corpora lutea (CL) were numerically smaller, and for the immunohistochemical parameters investigated, in the transglutaminase 2 (TGM2), gliadin, IgA, IgM, CD4 and CD8 were immunopositivity higher (P>0.05). It was determined that, in Wheat Group, ovarian tissue LH levels had significantly decreased, whilst serum HIGHLIGHTS• The cereals are a significant food source for both humans and animals.• The balanced nutrition is critical to the development of the reproductive system.• The serum lipid profile is critical to the development of multiple diseases.• Dietary gluten has effects on the immunohistochemical structure of the ovarian tissue.

show abstract

Section: Discussionmentioning

confidence: 58%

The Effects of Dietary Wheat and Corn Glutens on the Histopathological and Immunohistochemical Structure of the Ovarian Tissue and Serum and Ovarian Tissue LH and FSH Levels and Lipid Profiles in Rats

İmik

Kapakin

Karabulutlu

et al. 2023

Braz. arch. biol. technol.

Self Cite

View full text Add to dashboard Cite

show abstract

The Effect of Intermittent Fasting and Exercise on Body Composition, Antioxidant Capacity, and Blood Parameters in Obese Rats

Tatar,

Tek

2023

Braz. arch. biol. technol.

View full text Add to dashboard Cite

The effect of adding wheat and corn gluten to the diet of rats on the autoimmune and histopathological parameters in the intestine and liver

Gümüş,

Terim Kapakin,

Kirman

et al. 2024

RC FCV-LUZ

View full text Add to dashboard Cite

This study investigated the histopathological and immunohistochemical effect on the intestine and liver tissues with addition of the soybean meal (SBM), wheat Gluten meal (WGM) and Corn gluten meal (CGM) to rat diet. A total of 24 average twenty–day–old male rats (Wistar albino) were used in the study. The rats were randomly divided into 3 groups with 8 animals in each group (Control, Wheat and Corn groups). The diet provided to all three groups contained proteins, which were SBM, WGM and CGM in the Control, Wheat and Corn groups, respectively. In the study, the group fed with SBM was used as the Control group. Rats were fed a diet containing 22% crude protein and 2,598 kcal·kg-1 metabolic energy throughout the experimental period. The feeding trial was continued for a period of 50 days. Degenerative changes of varying severity in intestinal epithelial cells and atrophy in villi were observed. Similarly, the degenerative changes, especially vacuolar or hydropic degeneration were determined in hepatocytes. It was determined that the CD4 level were statistically significantly increased in the Wheat and Corn groups compared to the Control group (P<0.01) on intestine tissue. Also, it was determined that the IgA level was statistically significantly increased of the Wheat and Corn groups in liver tissue. (P<0.05). As a result, it was observed that the histopathological and immunohistochemical parameters of the intestine and liver tissues of the rats fed with diets containing highly WGM and CGM were limitedly affected.

show abstract

Investigation of the Effects of Glutens on Serum Interleukin-1 Beta and Tumor Necrosis Factor-Alpha Levels and the Immunohistochemical Distribution of CD3 and CD8 Receptors in the Small Intestine in Male Rats

Cited by 3 publications

References 26 publications

The Effects of Dietary Wheat and Corn Glutens on the Histopathological and Immunohistochemical Structure of the Ovarian Tissue and Serum and Ovarian Tissue LH and FSH Levels and Lipid Profiles in Rats

The Effects of Dietary Wheat and Corn Glutens on the Histopathological and Immunohistochemical Structure of the Ovarian Tissue and Serum and Ovarian Tissue LH and FSH Levels and Lipid Profiles in Rats

The Effect of Intermittent Fasting and Exercise on Body Composition, Antioxidant Capacity, and Blood Parameters in Obese Rats

The effect of adding wheat and corn gluten to the diet of rats on the autoimmune and histopathological parameters in the intestine and liver

Contact Info

Product

Resources

About