Pre-treatment by Rosemary Extract or Cell Transplantation Improves Memory Deficits of Parkinson’s Disease: When Tradition Meets the Future

Abstract

significant difference of time spent in the target quadrant between groups during probe trial at 4 and 8 weeks' postlesion. Cell and RE groups spent a significantly longer period in the target quadrant and had lower latency as compared with lesion. Treated groups have a significantly higher neuronal density in hippocampus compared to water, α-MEM and lesion groups. BrdU positive cells were presented in lesioned sites. The GFAP (Glial fibrillary acidic protein) positive cells were reduced in treated and sham groups compared to the water, α-MEM and lesion groups. Oral administration of RE (Rosemary extract) or ADSCs injection could improve memory deficit in the Parkinsonian rat by neuroprotection.