Ameliorative Effects of Thymoquinone on Sperm Parameters and Testosterone Level of Nicotine-Treated Sprague Dawley Rats

Rosli, Farah Dayana; Hashim, Noor Hashida; Osman, Khairul; Ibrahim, Siti Fatimah; Kabir, Nurul

doi:10.1590/1678-4324-2019180039

Cited by 5 publications

(4 citation statements)

References 40 publications

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“…Both 7.5 and 15 mg/kg TQ had no effect on seminiferous tubules, tunica albuginea and germinal epithelium thickness and testis weight. Rosli et al (2019) demonstrated that oral administration of 5 mg/kg TQ to rats for 30 days significantly decreased the viable sperms, while the number of sperm and level of testosterone hormone was not affected by TQ, 35 which was similar to our results at level of 15 mg/kg TQ. It seems that the beneficial or detrimental effects of TQ on male reproductive system depend on the dose applied, and also the duration of administration.…”

Section: Discussionsupporting

confidence: 92%

Thymoquinone ameliorates bleomycin-induced reproductive toxicity in male Balb/c mice

et al. 2021

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Bleomycin (BL) is a powerful chemotherapy drug that has devastating effects on spermatogenic function and may make cancer survivors at risk of infertility. Protective effects of thymoquinone (TQ), a phytochemical compound with antioxidant and anticancer influences, were investigated on sperm parameters, testicular structures, and sexual hormones in BL-treated mice. Forty-eight adult male Balb/c mice were randomly divided into six groups. Control group received normal saline; BL group received 10 mg/kg BL; TQ7.5 group received 7.5 mg/kg TQ; TQ15 group received 15 mg/kg TQ; BL+TQ7.5 group received 10 mg/kg BL and 7.5 mg/kg TQ; BL + TQ15 group received 10 mg/kg BL and 15 mg/kg TQ. BL was intraperitoneally used every day through 35 days, and TQ was intraperitoneally injected 3 days before administration of BL and continued twice per week for 35 days. Results showed that BL significantly decreased count, viability, morphology, maturity, and progressive movement of sperm, testosterone, seminiferous tubule diameters, the ratio of testis weight to body weight, number of spermatogonia, spermatocytes, spermatids, and Sertoli cells per tubule, and expression of Bcl2l1 and Bcl2l1/Bax ratio, and increased the non-progressive movement and immotile sperm, intermediate and immature sperm, LH, FSH, and malondialdehyde levels, and tunica albuginea thickness compared to the control group ( p < .05). TQ at a level of 7.5 mg/kg ameliorated BL-induced toxicity on measured parameters and returned most of them to the level of the control group. These data suggested TQ in a dose-dependent manner may have positive effects on BL-induced toxicity of the testis in mice model.

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Section: Discussionsupporting

confidence: 92%

Thymoquinone ameliorates bleomycin-induced reproductive toxicity in male Balb/c mice

et al. 2021

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“…Gökçe et al (2011) [156] established that TQ administration in mice lessened interstitial space dilatation and the deleterious manifestations in testis caused by methotrexate. TQ demonstrated ameliorative potential against the detrimental effects of nicotine towards sperm count, membrane, mitochondria and testosterone level [157]. TQ ameliorated testicular damage and improved sperm quality in varicocele-induced adolescent rats by reducing apoptosis, oxidative stress, and lipid peroxidation [158].…”

Section: Effects Of Tq On Male Infertilitymentioning

confidence: 94%

Occurrence and Bioactivity Diversity of Thymoquinone: An Overview

Samra

Ahmed

Shaker³

et al. 2022

Octahedron Drug Research

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Nigella sativa L. seeds are traditionally known for their ability to cure different diseases including airway and digestive system disorders, back pain, chronic headache, paralysis, diabetes, hypertension, and skin diseases. Keeping in view the numerous traditional medicinal uses of N. sativa seeds which may be related to thymoquinone (TQ), the main component of its essential oil, we provide an overview of the biological efficacy and toxicology of TQ to support their therapeutic potential in treatment of human diseases. The current review covers the recent literature from 2002 to 2021. The data was collected from books, journals, electronic searches (Pub Med, ScienceDirect, Google Scholar, and Springerlink), and theses. Thymoquinone exhibits importance in combating various diseases such as inflammation, arthritis, ulcerative colitis, cancer. Also, it showed ability to cure neuropathic pain, male infertility, diabetes, hepatitis, cardiovascular, musculoskeletal, respiratory, renal, skin, microbial infection, and neurodegenerative diseases comprising Parkinson's and Alzheimer's. That explains the traditional uses of N. sativa seeds in folk remedies in curing different ailments. The current review provides an explanation of the ethnopharmacological uses of N. sativa L. seeds which are related to the pharmacological activities of TQ. The pharmacological properties, pharmacokinetics, efficacy, high therapeutic index, lipophilicity, and safety margin make TQ a hopeful candidate for drug development.

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“…Nigella sativa oil and its active constituents have been reported by several authors to improve sperm parameters. 12,30,31 Mahdavi et al, 31 reported that the antioxidant properties of Thymoquinone may be responsible for the neutralized free radicals in semen and improved sperm parameters. a: significant decrease (P<0.05) when compared with the control group.…”

Section: Effects Of Thymoquinone On Sperm Parameters In Lead Acetate-...mentioning

confidence: 99%

“…This work is licensed under the Creative Commons Attribution 4.0 International License caused by testicular injury through oxidative stress. 12 However, the role of TQ against lead acetate-induced nephrotoxicity in male Wistar rats has not been fully elucidated. Therefore, the present study investigated the ameliorative role of TQ on male reproductive functions in lead acetate-induced reproductive toxicity in male Wistar rats.…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Potential of Thymoquinone on Male Reproductive Functions in Lead Acetate-Induced Reproductive Toxicity in Male Wistar Rats

2023

TJNPR

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Lead is revealed to have unfavorable results on reproductive function, particularly in males. 5 Therefore, this study is one of the concerted efforts in search of alternative ideal curative substances against the deleterious effects of lead-acetate-induced nephrotoxicity particularly in males. Among many medicinal plants, Nigella sativa (Ranunculaceae herbaceous plant), is a medicinally promising herb that has been researched and is well-known for its pharmacological benefits. The seeds of Nigella sativa known as black seed or black cumin are being used as medicine globally having anti-oxidant, anti-fertility, antiinflammatory gastro-protective, anti-tumor, anti-anxiety, and antimicrobial properties. 6,7 Black seed has an active effect on reproductive functions and infertility treatment as it has been demonstrated to cause significant improvements in reproductive parameters such as sperm count, semen qualities, Leydig cells count, follicular development, corpus luteum, and gonadotropic hormones like testosterone and progesterone. 8 Nigella sativa has many different chemical ingredients including thymoquinone (30-48%), flavonoids, anthocyanins, alkaloids, and essential fatty acids, particularly linoleic and oleic acids. 9 Thymoquinone (TQ), the main antioxidant constituent of Nigella sativa seed oil has shown beneficial effects on semen quality and reproductive functions. Several reports have shown that TQ plays a role to increase Leydig cell number and testosterone levels which eventually improved spermatogenesis. 9,10,11 Thymoquinone also exerts marked antioxidant characteristics which could ameliorate the spermatogenesis impairment

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Ameliorative Effects of Thymoquinone on Sperm Parameters and Testosterone Level of Nicotine-Treated Sprague Dawley Rats

Cited by 5 publications

References 40 publications

Thymoquinone ameliorates bleomycin-induced reproductive toxicity in male Balb/c mice

Thymoquinone ameliorates bleomycin-induced reproductive toxicity in male Balb/c mice

Occurrence and Bioactivity Diversity of Thymoquinone: An Overview

Ameliorative Potential of Thymoquinone on Male Reproductive Functions in Lead Acetate-Induced Reproductive Toxicity in Male Wistar Rats

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