Protective Effect of Rosa Canina Extract Against Doxorubicin-induced Testicular Toxicity in Mice

Nowrouzi, Fatemeh; Azadbakht, Mehri; Kalehoei, Eshrat; Modarresi, Masoud

doi:10.1590/1678-4324-2019180017

Cited by 11 publications

(9 citation statements)

References 45 publications

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“…Consistent with these reports, our results demonstrated that the prominent reduction in morphometric parameters and consequence a decreased testicular weight in rats treated with doxorubicin was due to germ cell loss. Our findings were supported by other studies (Nowrouzi et al., 2019; Türedi et al., 2015). ALA administrations proved the body and relative testis weight and morphometric parameters in the DOX + ALA group.…”

Section: Discussionsupporting

confidence: 93%

“…Testosterone is a necessary hormone for the maintenance of spermatogenesis, germ cell growth and seminiferous tubule morphology in the testis (Salihu et al., 2017). DOX administration has been reported to reduce testosterone levels in studies with rats and mice (Belhan et al., 2020; Nowrouzi et al., 2019). Consistently, in our study, it was determined that serum testosterone levels decreased significantly with DOX treatment.…”

Section: Discussionmentioning

confidence: 99%

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Alpha‐lipoic acid may ameliorate testicular damage by targeting dox‐induced altered antioxidant parameters, mitofusin‐2 and apoptotic gene expression

Güzel

Tektemur

2021

Andrologia

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In the study, the ameliorating effects of alfa lipoic acid (ALA) against doxorubicin‐induced testicular apoptosis, oxidative stress and disrupted mitochondrial fusion were investigated in male rats. Rats were divided into four groups as control, doxorubicin (DOX), DOX + ALA and ALA. A single dose of 15 mg/kg DOX was administered i.p to the DOX and DOX + ALA groups. 50 mg/kg ALA was given to the DOX + ALA and ALA groups by oral gavage every other day. After 28 days, rat testes and serum samples were collected and analysed. Administration of DOX alone caused a decrease in body and relative testicular weights, seminiferous tubule diameter and germinal epithelium thickness, Johnsen's score and serum testosterone levels. DOX treatment led to severe testicular damage such as tubular degeneration, and atrophic tubules. Also, the activities of superoxide dismutase and glutathione peroxidase were reduced, while the level of malondialdehyde was increased in the testis. The mRNA levels of apoptotic‐related genes (CASP3, TP53, BAX, BCL2) and apoptotic index were increased, while mitofusin‐2 decreased. DOX caused an increase in CASP3 and a decrease in mitofusin‐2 immunoreactivities. Treatment with ALA markedly improved all of DOX‐induced biochemical, histochemical and molecular alterations in rat testis. Consequently, ALA has a therapeutic role in ameliorating DOX‐induced testicular damage in rats.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Alpha‐lipoic acid may ameliorate testicular damage by targeting dox‐induced altered antioxidant parameters, mitofusin‐2 and apoptotic gene expression

Güzel

Tektemur

2021

Andrologia

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“…Previous studies have reported that DOX causes testicular toxicity and significant histopathological changes in testicular tissue (Gurel et al, 2019;Renu & Gopalakrishnan, 2019). In DOX-induced testicular toxicity in mice, Nowrouzi et al (2019) found that the body and testicular weights of the mice in the DOX group were significantly lower than the other groups at the end of the study. They also showed that DOX caused a significant reduction in parameters such as testicular diameter and seminiferous tubule diameter.…”

Section: Bcl-2 Immunoreactivitymentioning

confidence: 74%

Comparison of the protective effects of curcumin and caffeic acid phenethyl ester against doxorubicin‐induced testicular toxicity

et al. 2020

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Testicular dysfunction is one of the serious side effects of cytotoxic chemotherapy. It has been reported that low sexual function and quality of life and infertility concerns associated with gonadal insufficiency in young patients are related to psychosocial distress (Levi et al., 2015). Doxorubicin (DOX, brand name Adriamycin), which is one of the most important cornerstones of many chemotherapeutic protocols, is an anticancer drug selected in the treatment of many chemo-responsive tumours from ovarian, breast, liver and lung cancer and lymphomas. However, DOX can cause severe dose-dependent toxicity for other nontarget tissues, including testicular tissues (e.g. reduced testicular weight; Nishi et al., 2018). Studies have reported that DOX toxicity causes testicular damage and apoptosis and adversely affects reproductive function (Kopalli et al., 2016; Nowrouzi et al., 2019). In addition, DOX has been reported to increase oxidative stress by reducing antioxidant capacity in testicular tissue (Uyeturk et al., 2014). Does DOX cause testicular toxicity by only increasing oxidative stress and apoptosis? Or does DOX have an effect on testicular

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“…Reduction in organ weight is the most prominent sign of testicular toxicity ( Fallahzadeh et al, 2017 ; Nowrouzi et al, 2019 ). All EBN doses applied in this study, however, demonstrated no obvious testicular toxicity as the organ coefficient of the testes, epididymis, and seminal vesicle showed no significant difference between the groups.…”

Section: Discussionmentioning

confidence: 99%

Edible Bird’s Nest Supplementation Improves Male Reproductive Parameters of Sprague Dawley Rat

et al. 2021

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Edible bird’s nest (EBN) is reported to have a positive in vitro proliferative effect and contain male reproductive hormones. Spermatogonia cells proliferate during spermatogenesis under male reproductive hormones stimulation that include testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH). Characterization of EBN through liquid chromatography-mass spectrometry (LCMS) has found testosterone as a base peak. Six types of amino acids, estradiol and sialic acid were among the major peaks that have been characterized. Based on the presence of these reproductive components, this study evaluated different doses of EBN on sperm parameters and male reproductive hormones of Sprague Dawley rats. Sixteen Sprague Dawley rats at the age of eight weeks were randomly and equally divided into four groups, which are Control, 10 mg/kg BW/d 50 mg/kg BW/d, and 250 mg/kg BW/d EBN group. The rats were fed with EBN enriched pellet daily and water ad-libitum. Rats were sacrificed and the organ was weighed for organ coefficients after eight weeks of treatment. Sperm concentration, percentage of sperm motility, and sperm viability were evaluated. Meanwhile, ELISA method was used to measure testosterone, FSH, and LH. Findings showed that there were no significant differences in organ coefficient between groups. Supplementation of 250 mg/kg BW/d EBN demonstrated a significant increase in sperm concentration, percentage of sperm motility as well as FSH and LH level compared to 10 mg/kg BW/d group. There was a dose-dependent increase in testosterone level but was not significant between groups. Based on these findings, EBN is concluded to have crucial effects on male reproductive parameters.

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Protective Effect of Rosa Canina Extract Against Doxorubicin-induced Testicular Toxicity in Mice

Cited by 11 publications

References 45 publications

Alpha‐lipoic acid may ameliorate testicular damage by targeting dox‐induced altered antioxidant parameters, mitofusin‐2 and apoptotic gene expression

Alpha‐lipoic acid may ameliorate testicular damage by targeting dox‐induced altered antioxidant parameters, mitofusin‐2 and apoptotic gene expression

Comparison of the protective effects of curcumin and caffeic acid phenethyl ester against doxorubicin‐induced testicular toxicity

Edible Bird’s Nest Supplementation Improves Male Reproductive Parameters of Sprague Dawley Rat

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