Endophytic Fungi as Novel Resources of natural Therapeutics

Rajamanikyam, Maheshwari; Vadlapudi, Varahalarao; Amanchy, Ramars; Upadhyayula, Suryanarayana Murty

doi:10.1590/1678-4324-2017160542

Cited by 85 publications

(59 citation statements)

References 147 publications

(47 reference statements)

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“…The advent of microbial biotechnology has helped in establishing the fact that microorganisms play significant roles in industry, agriculture, and medicine (Gouda et al, 2016;Rajamanikyam et al, 2017). Having a better understanding of the diverse roles microorganisms play in the ecosystem will enhance the ways they can be applied in the field of agriculture most importantly for plant growth and crop yield (Nair and Padmavathy, 2014).…”

Section: An Overview Of Endophytesmentioning

confidence: 99%

“…Plant-endophyte interaction triggers the protection of plants against harmful conditions of the environment such as heavy metal presence and drought (Khan et al, 2019;Kushwaha et al, 2019). Endophytes are numerous and studies have it that they are present in many plants; they became important due to their capacity to produce many bioactive metabolites and biotechnologically relevant enzymes (Khan et al, 2014;Rajamanikyam et al, 2017). Most times when endophytes are inoculated in the plant, they produce significant biomass increment and also help in boosting commercial agriculture (Santoyo et al, 2016;Shen et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Elucidating Mechanisms of Endophytes Used in Plant Protection and Other Bioactivities With Multifunctional Prospects

Fadiji

Babalola

2020

Front. Bioeng. Biotechnol.

274

193

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Endophytes are abundant in plants and studies are continuously emanating on their ability to protect plants from pathogens that cause diseases especially in the field of agriculture. The advantage that endophytes have over other biocontrol agents is the ability to colonize plant's internal tissues. Despite this attributes, a deep understanding of the mechanism employed by endophytes in protecting the plant from diseases is still required for both effectiveness and commercialization. Also, there are increasing cases of antibiotics resistance among most causative agents of diseases in human beings, which calls for an alternative drug discovery using natural sources. Endophytes present themselves as a storehouse of many bioactive metabolites such as phenolic acids, alkaloids, quinones, steroids, saponins, tannins, and terpenoids which makes them a promising candidate for anticancer, antimalarial, antituberculosis, antiviral, antidiabetic, anti-inflammatory, antiarthritis, and immunosuppressive properties among many others, even though the primary function of bioactive compounds from endophytes is to make the host plants resistant to both abiotic and biotic stresses. Endophytes still present themselves as a peculiar source of possible drugs. This study elucidates the mechanisms employed by endophytes in protecting the plant from diseases and different bioactivities of importance to humans with a focus on endophytic bacteria and fungi.

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Section: An Overview Of Endophytesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Elucidating Mechanisms of Endophytes Used in Plant Protection and Other Bioactivities With Multifunctional Prospects

Fadiji

Babalola

2020

Front. Bioeng. Biotechnol.

274

193

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“…Em alguns casos, podem aumentar a capacidade das plantas de tolerar estresses abióticos e bióticos (Pamphile et al, 2017). O potencial biotecnológico de fungos endofíticos é enfatizado pela quantidade de investigações científicas nesta área, mostrando que esses microrganismos podem produzir um número muito grande de compostos, muitos dos quais têm atividades biológicas de interesse (Rajamanikyam et al, 2017). Dentre as biomoléculas secretadas pelos fungos endofíticos, destacamse os polissacarídeos.…”

Section: Introductionunclassified

Seleção E Produção De Exo E/Ou Polissacarídeos De Origem Microbiana Da Amazônia Para O Uso Em Odontologia / Selection and Production of Exo and/or Polysaccharides of Microbial Origin From the Amazon for Use in Dentistry

Filho

Souza

Hanan

et al. 2020

BJD

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Colletotrichum, Aspergillus, Paecilomices, Xylaria, Phomopsis e Pestalotiopsis, em meio de cultura batata-dextrose, acrescido de 0,2% de extrato de levedura, a 24±1° C por 21 a 28 dias. O micélio foi separado por filtração a vácuo e os constituintes fixos extracelulares (meio de cultura fermentado) e intracelulares (micélio) foram extraídos com metanol sob refrigeração a 4 o C. Os ensaios para determinação da atividade antimicrobiana foram realizados em placas de ELISA de 96 poços. As amostras foram divididas em 6 grupos: GC-cimento de agregado trióxido mineral branco (MTA) Angelus ® e G2 a G6-parte do pó de MTA foi substituído, em diferentes concentrações (5%,10%,15%, 20%, 25%), pela fração extraída do cultivo do fungo endofítico P. microspora. O gênero Pestalotiopsis mostrou-se mais efetivo nos testes antimicrobianos, especificamente o P. microspora, com a concentração inibitória mínima de 0,125 para E. feacalis, 0,25 para S. aureus, P. aeruginosa, C. albicans e 0,5 para C. tropicalis. Na avaliação da atividade antimicrobiana do cimento experimental, houve atividade para o S. aureus, E. coli, P. aeruginosa e E. feacalis nos grupos GC, G5 (MTA + 20%) e G6 (MTA + 25%). O G6 apresentou os maiores valores e não houve diferença significativa entre os grupos de E. coli, S. aureus e E. faecalis. A adição do extrato de polissacarídeos intracelulares do P. microspora melhorou a atividade antimicrobiana do MTA, constituindo-se em uma alternativa promissora para o uso odontológico.

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“…Thus, immense potential exists in screening biodiversity of endophytic fungi for exploring novel chemistries possessing enzymatic and antibacterial properties (Uzma et al, 2018). Natural compounds isolated from medicinally important plants are considered to be conventionally leading agents revealing the unexplored chemical diversity incomparable to the principal combinatorial databases (Rajamanikyam et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Anti-Staphylococcal Potential of Fusarium Sp: Fungal Endophyte Isolated From Rauwolfia Serpentina

Gambhir¹

2020

J microb biotech food sci

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Fungal endophytes are considered as repository of potent novel bioactive compounds with profuse chemical diversity. These bioactive compounds have been widely utilized in pharmaceutical and agrochemical industries. The present work was undertaken to bio-prospect the fungal endophytes from Rauwolfia serpentina, a medicinal plant used in multiple indigenous preparations, for possible therapeutic interventions. 21 fungal endophytes were isolated from Rauwolfia serpentina with maximum colonization in leaf (42.8 %) followed by bark (33.3%) and stem (23.8%). In the enzymatic activity screening, #15RSBNEY was found to be potent amylase producer and #3RSSTNEY as potential cellulase producer. Further, three isolates viz. #16RSLBRT, #10RSLBRT and #23RSSTNEY exhibited promising antibacterial activity with maximum activity exhibited by #10RSLBRT against all test strains of Staphylococcus aureus. Interestingly, it was observed that antibacterial activity of #10RSLBRT increased by two fold after fractionation with acetone and chloroform. Based on above result, the culture filtrate of #10RSLBRT was extracted with hexane, chloroform and ethyl acetate followed by agar well gel diffusion method for antibacterial activity. The crude ethyl acetate residue of #10RSLBRT hereby exhibited potent antibacterial activity. The potential isolate i.e. #10RSLBRT was identified by molecular taxonomic tools using internal transcribed spacer rDNA analysis and was clustered in the Fusarium incarnatum-equiseti complex. Further studies on the characterization of bioactive compounds of ethyl acetate extract of # 10RSLBRT are warranted for the development of anti-staphylococcal therapy.

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Endophytic Fungi as Novel Resources of natural Therapeutics

Abstract: Fungal endophytes constitute a major part of the unexplored fungal diversity. Endophytic fungi (EF like anticancer, antibacterial, antiviral, immunomodulatory, antidiabetic, antioxidant, anti-arthritis and anti-inflammatory.

Cited by 85 publications

References 147 publications

Elucidating Mechanisms of Endophytes Used in Plant Protection and Other Bioactivities With Multifunctional Prospects

Elucidating Mechanisms of Endophytes Used in Plant Protection and Other Bioactivities With Multifunctional Prospects

Seleção E Produção De Exo E/Ou Polissacarídeos De Origem Microbiana Da Amazônia Para O Uso Em Odontologia / Selection and Production of Exo and/or Polysaccharides of Microbial Origin From the Amazon for Use in Dentistry

Anti-Staphylococcal Potential of Fusarium Sp: Fungal Endophyte Isolated From Rauwolfia Serpentina

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