Multipotent male germline stem cells (mGSCs) from neonate porcine testis

Niu, Zhiwei; Wu, Siyu; Wu, Chongyang; Li, Na; Zhu, Haijing; Liu, Weishuai; Hua, Jinlian

doi:10.1590/1678-4324-2016150449

Cited by 4 publications

(1 citation statement)

References 32 publications

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“…It should be noted that high differentiation capacity of the mammalian maGSCs has been demonstrated by several studies [32][33][34]. In fact, these stem cells, derived from adult mouse testis (GSCs), could show the characteristics ESC-pluripotency including the expression of the PSCs specific transcription factors and differentiation into three embryonic germ layers including heart lineages and functional CMCs [18,35,36]. Similarly, having an equal ESC property in the human GSCs has been reported by Meyer, et al in 2010 [37].…”

Section: Stem Cellsmentioning

confidence: 99%

Application of Stem Cell Technologies to Regenerate Injured Myocardium and Improve Cardiac Function

Mardanpour

Nayernia²,

Khodayari

et al. 2019

Cell Physiol Biochem

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In the recent decades, cardiovascular diseases emerged as the major leading cause of human mortality. However, current clinical approaches still do not encompass a thorough therapeutic solution for improving heart function of the patients who suffered an extensive myocardial injury. Based on this status quo, stem cells could become a novel option, as a natural source of the new myocardium lineage cells, being capable of paracrine factors secretion, protection or even regeneration of the damaged heart muscle. Efficient stem cell-based therapy of the heart should lead to repair or/and replacement of the degenerated tissue with functional myocardial and endothelial cells. Hereon, various types of pluripotent and multipotent stem cells have been already studied in the pre-clinical and clinical settings, demonstrating their cardiomyogenic and regenerative potential. In this context, as a type of male adult stem/ progenitors, spermatogonial stem cells feature a remarkable ability for a formation of cardiovascular lineages, based on our own observations. Presented data supports the presumption, that spermatogonial stem cells not only have a suitable capacity to generate functional heart cells but can also potentially improve the function of an injured myocardium. In this review article, we first describe the essential molecular and pathophysiological mechanisms involved in the heart tissue injury. Afterwards, based on our ongoing study, we review the impact of the stem cell technologies on the regeneration therapy in cardiovascular and myocardial diseases. Particular emphasis is being put on the usability of spermatogonial stem cells in cardiac therapy. Review

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