Transgenic Expression and Identification of Recombinant Human Proinsulin in Peanut

Zheng, Ling; Qi-Qing, Jiao; Wang, Yu; Bian, Fei; Qu, Shujie; Wan, Shungang; Peng, Zhenying; Bi, Ye

doi:10.1590/1678-4324-2016150131

Braz. arch. biol. technol.

2016

DOI: 10.1590/1678-4324-2016150131

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Transgenic Expression and Identification of Recombinant Human Proinsulin in Peanut

Ling Zheng

Jiao Qi-Qing

Yu Wang

et al.

Abstract: The increased incidence of diabetes, coupled with the introduction of alternative insulin delivery methods that rely on

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2023

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A Brief Atlas of Insulin

Ayan

DeMi̇rci̇

2023

CDR

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Insulin is an essential factor for mammalian organisms: a regulator of glucose metabolism and other key signaling pathways. Insulin is also a multifunctional hormone whose absence can cause many diseases. Recombinant insulin is widely used in the treatment of diabetes. Understanding insulin, biosimilars and biobetters from a holistic perspective will help pharmacologically user-friendly molecules design and develop personalized medicine-oriented therapeutic strategies for diabetes. Additionally, it helps to understand the underlying mechanism of other insulin-dependent metabolic disorders. The purpose of this atlas is to review insulin from a biotechnological, basic science, and clinical perspective; explain nearly all insulin-related disorders and their underlying molecular mechanisms; explore exogenous/recombinant production strategies of patented and research-level insulin/analogs; and highlight their mechanism of action from a structural perspective. Combined with computational analysis, comparisons of insulin and analogs also provide novel information about the structural dynamics of insulin.

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A Brief Atlas of Insulin

Ayan

DeMi̇rci̇

2023

CDR

View full text Add to dashboard Cite

show abstract

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Transgenic Expression and Identification of Recombinant Human Proinsulin in Peanut

Abstract: The increased incidence of diabetes, coupled with the introduction of alternative insulin delivery methods that rely on

Cited by 1 publication

References 36 publications

A Brief Atlas of Insulin

A Brief Atlas of Insulin

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