Distribution of selenium in sheep treated with dipheny diselenide

Abstract

The aim of the present study was to report the in vivo distribution of selenium in sheep. For this, animals were allocated into two groups (control group and treated group) and kept in metabolic cages for a period of 37 days. The treated group received a single dose (6µmol/kg) of Diphenyl Diselenide, intravenously. Plasma and erythrocytes samples were collected at different times. Adipose tissue, muscles (latissimusdorsi, semitendinosus, and supra-scapular) heart, liver, lung, kidney, intestine and brain were sampled at 30 days post-treatment, in order to determine the selenium concentration. The results demonstrated that the selenium, from the Diphenyl Diselenide group, was higher in erythrocytes (4.8mg/L, six hours post-treatment) when compared with the control sheep. The deposition of selenium occurred in the liver (7.01µg/g), brain (3.53µg/g) and kidney (2.02µg/g). After 30 days of a single intravenous injection of Diphenyl Diselenide, liver was the main organ of selenium deposition.

Toxicology and pharmacology of synthetic organoselenium compounds: an update

“…By the intravenous route, sheep treated with a single dose of diphenyl diselenide (6 µmol kg −1 ) did not have any overt sign of toxicity until the end of observational period, namely 37 days (Leal et al 2018 ).…”

Effect of Prepartum Maternal Supplementation with Diphenyl Diselenide on Biochemical, Immunological, and Oxidative Parameters of the Offspring

“…Shortly after this decline, the DD group exhibited a substantial increase in IgG concentrations compared to the other groups at 56 and 70 days of age. We attribute this increase to the previously documented ability of (PhSe) 2 to accumulate in deeper tissues, such as the liver, kidneys, and brain, and gradually distribute in the bloodstream [ 17 ]. Therefore, we believe that (PhSe) 2 remained in storage sites and, through its continuous release, contributed to the development of humoral immunity in calves.…”

“…The results showed that its subcutaneous application is safe, even when administered in varying doses. This is because diphenyl diselenide did not induce any signs of toxicity in animals subjected to various treatments [ 17 ]. Based on the information provided in this study, we began an investigation of the use of this molecule as an alternative mineral supplement to that typically used.…”

Efeito metafilático do disseleneto de difenila (PhSe)2 na saúde de bezerras de corte submetidas ao desmame convencional

“…In ruminants, (PhSe) 2 has been investigated in both sheep (Biazus et al, 2018;Leal et al, 2018) and bovine species (Santos et al, 2019;Rodrigues et al, 2020). Biazus et al (2018) explored the impact of (PhSe) 2 administration, at a dose of 3.0 µmol kg -1 diluted in 1.5 mL of DMSO via the subcutaneous route, on the milk composition, oxidative stress, and inflammatory response of recently lambed Lacaune dairy sheep.…”

“…Biazus et al (2018) explored the impact of (PhSe) 2 administration, at a dose of 3.0 µmol kg -1 diluted in 1.5 mL of DMSO via the subcutaneous route, on the milk composition, oxidative stress, and inflammatory response of recently lambed Lacaune dairy sheep. Leal et al (2018) assessed the selenium distribution throughout the bodies of five-month-old Texel sheep treated with (PhSe) 2 in a single dose of 6 μmol kg -1 diluted in 20 mL of DMSO intravenously. Santos et al (2019) analyzed the effects of (PhSe) 2 administration at a dose of 3 µmol kg -1 diluted in DMSO subcutaneously, with or without zinc edetate in two administrations at 20-day intervals, on the performance, immune response, protein and lipid metabolism, as well…”