Evaluation of central vestibular syndrome in dogs using brainstem auditory evoked responses recorded with surface electrodes

Stanciu, Gabriela Dumitriţa; Musteață, Mihai; Armasu, Mihaela; Solcan, G.

doi:10.1590/1678-4162-8820

Cited by 8 publications

(8 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cause of these higher concentrations of Aβ in patients with renal dysfunction without dialysis is not fully known. These results sustain the main role of kidney in Aβ hemostasis and the idea that impaired renal function could lead to inadequate Aβ clearance and thus contribute to the AD development [ 154 , 155 ].…”

Section: Effects Of Renal Replacement Therapies On Amyloid-beta Pasupporting

confidence: 66%

Renal Contributions in the Pathophysiology and Neuropathological Substrates Shared by Chronic Kidney Disease and Alzheimer’s Disease

et al. 2020

View full text Add to dashboard Cite

Chronic kidney disease and Alzheimer’s disease are chronic conditions highly prevalent in elderly communities and societies, and a diagnosis of them is devastating and life changing. Demanding therapies and changes, such as non-compliance, cognitive impairment, and non-cognitive anomalies, may lead to supplementary symptoms and subsequent worsening of well-being and quality of life, impacting the socio-economic status of both patient and family. In recent decades, additional hypotheses have attempted to clarify the connection between these two diseases, multifactorial in their nature, but even so, the mechanisms behind this link are still elusive. In this paper, we sought to highlight the current understanding of the mechanisms for cognitive decline in patients with these concurrent pathologies and provide insight into the relationship between markers related to these disease entities and whether the potential biomarkers for renal function may be used for the diagnosis of Alzheimer’s disease. Exploring detailed knowledge of etiologies, heterogeneity of risk factors, and neuropathological processes associated with these conditions opens opportunities for the development of new therapies and biomarkers to delay or slow their progression and validation of whether the setting of chronic kidney disease could be a potential determinant for cognitive damage in Alzheimer’s disease.

show abstract

Section: Effects Of Renal Replacement Therapies On Amyloid-beta Pasupporting

confidence: 66%

Renal Contributions in the Pathophysiology and Neuropathological Substrates Shared by Chronic Kidney Disease and Alzheimer’s Disease

et al. 2020

View full text Add to dashboard Cite

show abstract

“…There is no certainty whether the island amyloid is directly involved, or it is just the consequence of the disease. It is also unknown if diabetic hyperglycemia and insulin resistance induce amyloid deposition in the islets and brain [ 54 ].…”

Section: Amyloid Formation As a Common Pathological Feature In Botmentioning

confidence: 99%

Link between Diabetes and Alzheimer’s Disease Due to the Shared Amyloid Aggregation and Deposition Involving Both Neurodegenerative Changes and Neurovascular Damages

Stanciu

Bild

Ababei

et al. 2020

JCM

View full text Add to dashboard Cite

Diabetes and Alzheimer’s disease are two highly prevalent diseases among the aging population and have become major public health concerns in the 21st century, with a significant risk to each other. Both of these diseases are increasingly recognized to be multifactorial conditions. The terms “diabetes type 3” or “brain diabetes” have been proposed in recent years to provide a complete view of the potential common pathogenic mechanisms between these diseases. While insulin resistance or deficiency remains the salient hallmarks of diabetes, cognitive decline and non-cognitive abnormalities such as impairments in visuospatial function, attention, cognitive flexibility, and psychomotor speed are also present. Furthermore, amyloid aggregation and deposition may also be drivers for diabetes pathology. Here, we offer a brief appraisal of social impact and economic burden of these chronic diseases and provide insight into amyloidogenesis through considering recent advances of amyloid-β aggregates on diabetes pathology and islet amyloid polypeptide on Alzheimer’s disease. Exploring the detailed knowledge of molecular interaction between these two amyloidogenic proteins opens new opportunities for therapies and biomarker development.

show abstract

“…Diseases that may affect auditory function were excluded for all dogs via various tests. It is generally agreed that the BAER test is not affected by sedation or anesthesia (11,18), and medetomidine can be used when performing the BAER test (2,13,21). Therefore, we sedated the dogs using medetomidine.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Insert Earphones and Circumaural Earphones in the Brainstem Auditory-Evoked Response Test of Dogs

Kim¹,

Song²,

An³

et al. 2020

J Vet Clin

View full text Add to dashboard Cite

We aimed to investigate the differences in the efficacy of insert and circumaural earphones when performing the brainstem auditory evoked response (BAER) test with dogs. Hearing loss may occur congenitally or secondarily in dogs. The BAER test, unlike the classical ethological method, is the most reliable diagnostic tool to assess canine auditory function. Furthermore, there are certain advantages of using insert earphones rather than the standard, circumaural earphones. We subjected eight dogs to the BAER test with insert earphones and circumaural earphones. The result revealed that the latency of waves was delayed with an insert earphone. The inter-peak latency did not show any significant differences between the two transducers, and the threshold was higher when using an insert earphone. Moreover, the circumaural headphones produced a greater degree of crossover effect than the insert earphones, and this cross-over effect could affect the outcomes of the BAER test. Considering these results, we concluded that insert earphones may be more appropriate when performing the canine BAER test.

show abstract

Evaluation of central vestibular syndrome in dogs using brainstem auditory evoked responses recorded with surface electrodes

Cited by 8 publications

References 17 publications

Renal Contributions in the Pathophysiology and Neuropathological Substrates Shared by Chronic Kidney Disease and Alzheimer’s Disease

Renal Contributions in the Pathophysiology and Neuropathological Substrates Shared by Chronic Kidney Disease and Alzheimer’s Disease

Link between Diabetes and Alzheimer’s Disease Due to the Shared Amyloid Aggregation and Deposition Involving Both Neurodegenerative Changes and Neurovascular Damages

A Comparative Study of Insert Earphones and Circumaural Earphones in the Brainstem Auditory-Evoked Response Test of Dogs

Contact Info

Product

Resources

About