Toxicidade aguda e risco ambiental do antibiótico oxitetraciclina para tilápia ( Oreochromis niloticus ), Daphnia magna e Lemna minor

Machado, Ângela Aparecida; Américo-Pinheiro, Juliana Heloísa Pinê; Carraschi, Silvia Patrícia; Cruz, Claudinei da; Machado-Neto, J. G.

doi:10.1590/1678-4162-8732

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…The reason for reduced feed intake might be inappetence due to hepatic damage and/or poor palatability of the antibiotic-treated feed. A similar reduction in appetite and feed intake has been recorded in O. niloticus and P. mesopotamicus leading to low body weight gain and indirect loss to the farmer (Machado et al, 2016).…”

Section: Discussionsupporting

confidence: 74%

“…niloticus and P . mesopotamicus leading to low body weight gain and indirect loss to the farmer (Machado et al, 2016). Measurement of fish weight in the present study, however, revealed higher weight gain in treated fish, as compared to the control, indicating the growth promotion activity of the antibiotic.…”

Section: Discussionmentioning

confidence: 99%

“…Since OTC is effective and permitted for use in freshwater aquaculture, it has a strong potentiality of therapeutic or preventive use in Pangasius culture also. However, it is not totally safe and experiments have identified hepatotoxicity, and nephrotoxicity in animals and fish species like Oreochromis niloticus and Piaractus mesopotamicus (Machado et al, 2016; Reda et al, 2013). At cell level, it induces membrane lipids peroxidation, mitochondrial damage and impairment of respiration (Ding et al, 2017; Fromenty & Pessayre, 1997; Oda et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Determination of biosafety of the antibiotic oxytetracycline hydrochloride in Pangasianodon hypophthalmus

Manna

Bera

Das

et al. 2021

Aquaculture Research

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Pangasianodon hypophthalmus is one of the most important aquaculture species in Southeast Asia, with a significant contribution to the world fish basket. Like other crops, the striped catfish suffers from bacterial diseases that demand the use of antibiotics. The present study has evaluated the safety of oxytetracycline, one of the approved and commonly used antibiotics, in this species. Juvenile stages of the fish (31.16 ± 1.03 g) were administered with the antibiotic in feed at the dose rate of 80–800 mg kg−1 body weight daily for 30 days, followed by 10 days of withdrawal observation. Fish health was assessed by the study of behaviour and feed intake, haematology, blood biochemistry, and histopathology. Results showed that up to 30 days of antibiotic treatment resulted in no significant toxic effects in terms of behaviour and fish mortality. However, fish suffered from reduced feed intake and hepatotoxicity evidenced by proliferative and degenerative changes of hepatocytes, and increase in AST and ALT enzyme activities, especially in 400–800 mg kg−1 doses which, however, recovered after withdrawal of the drug. Although few fish died from a bacterial infection at the lowest concentration of the drug used, fish were able to mount adaptive physiological responses best at 80 mg kg−1 fish dosage. The study establishes that in‐feed administration of the antibiotic oxytetracycline @ 80 mg kg−1 fish biomass is safe for therapeutic use in P. hypophthalmus.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Determination of biosafety of the antibiotic oxytetracycline hydrochloride in Pangasianodon hypophthalmus

Manna

Bera

Das

et al. 2021

Aquaculture Research

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“…After exposure to the antibiotic, the sh showed irregular swimming behaviour and a high operculum beat, corroborating the behavior demonstrated for Nile tilapia juveniles (weight between 0.5 and 1.0 g) (Machado et al 2016). In studies with pollutants, these signs of stress and toxicity are reported as a response of the animal to relieve respiratory stress (Shrivastava et al 2011).…”

Section: Stress Testsupporting

confidence: 83%

Acute toxicity, risk assessment and exposure of Nile tilapia larvae after stress to sub-lethal concentrations of oxytetracycline

Takeshita

Chiste

Jonsson

et al. 2022

Preprint

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Median lethal concentration (LC50 − 96h), risk assessment, development, and mortality of Nile tilapia Oreochromis niloticus larvae exposed to oxytetracycline (OTC) after stress management were evaluated in this study. Fish (n = 126; 32.25 ± 3.74 mg; 13.01 ± 0.64 mm; 7 larvae/aquarium) were used for LC50 − 96h trial and randomly distributed in 21 aquaria (1 L) with 0.0, 2.01, 2.44, 3.31, 3.65 and 4.59 mg/L of OTC. For acute stress test, fish (n = 180; 33.9 ± 0.73 mg; 13.06 ± 0.72 mm; 10 larvae/aquarium) were submitted to air stress for 5 minutes and posteriorly randomly allocated in 18 aquaria (1 L) and exposed to 0.0, 0.03, 0.82, 1.65, 2.47 and 3.30 of OTC. Temperature, pH, dissolved oxygen (DO), conductivity, total ammonia and total hardness were measured daily. LC50 − 96h of OTC for Nile tilapia larvae was 3.45 mg/L. Weight and length of larvae submitted to graded levels of OTC decrease in both tests. Significant differences was observed for DO over 96h. pH, temperature and DO differ (P < 0.05) in post-stress test. Stress management (exposure to air) potentiates the toxic effects of sub-lethal doses of OTC. Furthermore, based on the risk quotient, OTC has a high risk to Nile tilapia larvae when exposed to therapeutic concentrations.

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Ecotoxicological assessment of amoxicillin trihydrate: Stability, solubility, and acute toxicity for Oreochromis niloticus, Lemna minor, and Daphnia magna

Moraes

Orlando

Prado

et al. 2022

Cleaner Chemical Engineering

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Toxicidade aguda e risco ambiental do antibiótico oxitetraciclina para tilápia ( Oreochromis niloticus ), Daphnia magna e Lemna minor

Cited by 5 publications

References 10 publications

Determination of biosafety of the antibiotic oxytetracycline hydrochloride in Pangasianodon hypophthalmus

Determination of biosafety of the antibiotic oxytetracycline hydrochloride in Pangasianodon hypophthalmus

Acute toxicity, risk assessment and exposure of Nile tilapia larvae after stress to sub-lethal concentrations of oxytetracycline

Ecotoxicological assessment of amoxicillin trihydrate: Stability, solubility, and acute toxicity for Oreochromis niloticus, Lemna minor, and Daphnia magna

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