Hemodynamic variables in piglets anesthetized with isoflurane or propofol, kept under spontaneous ventilation and FIO2 of 0.5

Ido, Cléber Kazuo; Silva, P.E.S.; Silva, H.R.A.; Biteli, E.G.F.; Carneiro, Rodrigo Lima; Lopes, P.C.F.; Gering, Ana Paula; Nunes, Newton

doi:10.1590/1678-4162-10845

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…Isoflurane causes vasodilation and reduces total peripheral resistance and therefore decreases blood pressure in a dose-dependent manner. 28,29 In this case, isoflurane was not required to maintain general anaesthesia until after transfer to theatre as anaesthetic depth was satisfactory, as assessed by lack of jaw tone, absence of a palpebral reflex and lack of movement. The minimum alveolar concentration of isoflurane in pigs is reported at approximately 1.5%.…”

Section: Discussionmentioning

confidence: 99%

Anaesthesia, analgesia and cardiovascular support in a Kunekune pig undergoing a complicated umbilical hernia repair

Dagnall¹,

Deutsch²

2023

Vet Record Case Reports

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This report describes the peri‐operative anaesthesia and analgesia management of a 5‐year‐old Kunekune pig undergoing surgical correction of an umbilical hernia. Premedication with azaperone (1 mg/kg), xylazine (0.5 mg/kg), butorphanol (0.2 mg/kg) and ketamine (5 mg/kg) intramuscularly preceded induction of anaesthesia with ketamine (2 mg/kg) intravenously. General anaesthesia was maintained with isoflurane in 100% oxygen. Analgesia was supported intraoperatively by a transversus abominis plane block with lidocaine (1.5 mg/kg), and a ketamine (10 μg/kg/min) infusion intravenously. Crystalloid fluid boluses and atropine intravenously were administered, and mechanical ventilation was stopped to aid correction of hypotension. Post‐operative analgesia was supported with a continuous infusion of ketamine (5 μg/kg/min) intravenously, butorphanol (0.2 mg/kg) intravenously every 6 hours, paracetamol (10 mg/kg) intravenously orally every 8 hours and meloxicam (0.4 mg/kg) intravenously orally every 24 hours. The pig made progressive clinical improvement and was discharged 7 days after the surgery.

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Section: Discussionmentioning

confidence: 99%

Anaesthesia, analgesia and cardiovascular support in a Kunekune pig undergoing a complicated umbilical hernia repair

Dagnall¹,

Deutsch²

2023

Vet Record Case Reports

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“…Cardiac output was estimated on a Windkessel model, it was calculated as the product of pulse pressure and heart rate, divided by 1000 [33]. Systemic vascular resistance was calculated as the ratio between mean arterial pressure and cardiac output, multiplied by a correction factor of 79.9 [34]. Finally, rate pressure product was calculated as the product of systolic arterial pressure and heart rate.…”

Section: F In-vivo Validationmentioning

confidence: 99%

Implantable Fiber Bragg Grating Sensor for Continuous Heart Activity Monitoring: Ex-Vivo and In-Vivo Validation

et al. 2021

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Continuous and reliable cardiac function monitoring could improve medication adherence in patients at risk of heart failure. This work presents an innovative implantable Fiber Bragg Grating-based soft sensor designed to sense mechanical cardiac activity. The sensor was tested in an isolated beating ovine heart platform, with 3 different hearts operated in wide-ranging conditions. In order to investigate the sensor capability to track the ventricular beats in real-time, two causal algorithms were proposed for detecting the beats from sensor data and to discriminate artifacts. The first based on dynamic thresholds while the second is a hybrid convolutional and recurrent Neural Network. An error of 2.7 ± 0.7 beats per minute was achieved in tracking the heart rate. Finally, we have confirmed the sensor reliability in monitoring the heart activity of healthy adult minipig with an error systematically lower than 1 Bpm.

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“…;Ido et al 2019). Median values (Q1-Q3) for HR, SpO 2 , PETCO 2 , SAP, MAP, DAP and core body temperature during the study were 90 (72.5-97.7) beats/minute, 99.5 (97.…”

mentioning

confidence: 96%

Modified passive leg-raising maneuver to predict fluid responsiveness by transthoracic ultrasound guidance in healthy pigs under sevoflurane anesthesia.

Tarragona,

Donati,

Zaccagnini

et al. 2024

Preprint

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This study aimed to evaluate whether the velocity-time integral of aortic blood flow (VTIAo) assessed by transthoracic echocardiography is significantly increased after passive leg-raising maneuver (PLRM) in anesthetized and mechanically ventilated fluid responder pigs. Eight healthy Landrace pigs were anesthetized, mechanically ventilated, and subjected to PLRM. Ultrasound-guided VTIAo measurements were taken before and after PLRM and compared to assess changes. Fluid challenge was then performed, and changes in VTIAo were assessed to classify pigs as fluid responders or non-responders. Following PLRM, fluid responders exhibited a significant increase in VTIAo compared to baseline (p = 0.017). An optimal cutoff of 11.2% for ΔVTIAo was calculated for predicting fluid responsiveness after PLRM, with an AUROC of 1.00 (95% CI not estimated – 1.00), sensitivity of 100% (95% CI 59 – 100%), specificity of 100% (95% CI 2.5–100%), positive predictive value of 100% (95% CI 59–100%), and a negative predictive value of 100% (95% CI 2.5–100%). This study demonstrates the potential of using ultrasound-guided VTIAo measurements associated with PLRM to predict fluid responsiveness in anesthetized pigs. A ΔVTIAo value of ≥11.2% reliably identified fluid-responsive pigs under anesthesia and mechanical ventilation, offering a non-invasive alternative to fluid challenges. Further research addressing study limitations could enhance understanding of fluid responsiveness assessment in animal models.

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Hemodynamic variables in piglets anesthetized with isoflurane or propofol, kept under spontaneous ventilation and FIO2 of 0.5

Cited by 5 publications

References 25 publications

Anaesthesia, analgesia and cardiovascular support in a Kunekune pig undergoing a complicated umbilical hernia repair

Anaesthesia, analgesia and cardiovascular support in a Kunekune pig undergoing a complicated umbilical hernia repair

Implantable Fiber Bragg Grating Sensor for Continuous Heart Activity Monitoring: Ex-Vivo and In-Vivo Validation

Modified passive leg-raising maneuver to predict fluid responsiveness by transthoracic ultrasound guidance in healthy pigs under sevoflurane anesthesia.

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