Reflections on becoming a senior surgeon

Dardik, Herbert

doi:10.1590/1677-5449.170101

Cited by 1 publication

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“…Using a rat model, Dardik, et al observed improved endothelial cell retention and reduced intimal thickening when EC-seeded grafts were pre-conditions with shear stress prior to implantation. [89] Additionally, many researchers are currently focusing on endothelializing cardiovascular biomaterials by scavenging appropriate cells from circulation. In this situation, the binding strength between the circulating cell and the surface must be sufficiently strong and fast forming to halt and adhere the desired cells from flow.…”

Section: Peptide In Vitro/in Vivo Cell Type Referencementioning

confidence: 99%

Promoting Endothelialization of Polymeric Cardiovascular Biomaterials

Heath

2017

Macro Chemistry & Physics

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The lack of a blood compatible synthetic interface is one of the largest unaddressed challenges in the field of biomaterials science. This technological shortcoming hinders the successful clinical application of small diameter vascular grafts and other cardiovascular devices such as stents and artificial heart valves. Therefore, intensive research activities are ongoing to develop polymer materials with improved blood compatibility. One attractive strategy to improve the blood compatibility of an interface is to design surfaces that promote the development of an endothelium, the monolayer of endothelial cells that line our native vasculature and is responsible for blood compatibility. This article describes the recent strategies that have been used to generate polymeric materials that promote the development of an endothelium, discusses shortcomings in the field, and proposes future directions of research that can be undertaken to design next generation polymeric biomaterial that promote endothelialization.

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Section: Peptide In Vitro/in Vivo Cell Type Referencementioning

confidence: 99%

Promoting Endothelialization of Polymeric Cardiovascular Biomaterials

Heath

2017

Macro Chemistry & Physics

View full text Add to dashboard Cite

show abstract

Reflections on becoming a senior surgeon

Cited by 1 publication

References 1 publication

Promoting Endothelialization of Polymeric Cardiovascular Biomaterials

Promoting Endothelialization of Polymeric Cardiovascular Biomaterials

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