Estresse oxidativo e a função endotelial: efeitos do exercício físico associado à lipemia pós-prandial

Krüger, Renata Lopes; Farinha, Juliano Boufleur; Oliveira, Álvaro Reischak de

doi:10.1590/1677-5449.01715

Cited by 7 publications

(4 citation statements)

References 61 publications

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“…Platelet count and volume were not influenced by food intake of dogs, however, Pavlishchuk et al (2004) reported that after feeding there may be an increase in plasma fibrinogen that modulates the early stages of platelet aggregation and its interrelation with other cells in humans, thus contributing to increased platelet aggregation. Corroborating these findings, Krüger, Farinha, Teixeira and Oliveira (2015) indicate that this response is probably due to endothelial dysfunction caused after eating. Taken together, these factors could contribute to postprandial platelet consumption.…”

Section: Resultsmentioning

confidence: 53%

Diurnal variations in canine hematological parameters after commercial feed feeding

Costa

Silva

Oliveira

et al. 2020

Semina: Ciênc. Agrár.

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Complete blood count (CBC) is the evaluation of blood cells, which provides resourceful information. Considering that inadequate fasting time is the most common pre-analytical error in laboratory diagnosis and is associated with lipemia in blood samples, which has not yet been adequately investigated in dogs, this study aimed to assess diurnal postprandial changes in the CBC of healthy dogs fed with industrialized feed. Eighteen clinically healthy dogs aged 2-6 years and weighing over 6 kg were enrolled in the study. All dogs received “Premium” industrialized feed every 12 hours. Blood was collected after a 12-hour fasting period at 6:00 am (baseline), followed by feeding and new blood samples collected hourly for the next 11 consecutive hours. Red blood cell (RBC) counts, red cell distribution width (RDW), white blood cell (WBC) counts, platelets, mean platelet volume (MPV) and hemoglobin were obtained using an automated veterinary cell counter. Hematocrit (HTC) was determined by Strumia's microcapillary method, differential leukocyte count was performed on hematological dye-stained blood smears and total plasma protein (TPP) was determined using refractometry. Variables were tested for normality and differences were considered significant when p < 0.05. A statistically significant decrease was observed in the erythrogram from 2 h for RBC and hemoglobin, from 3 h for HTC and from 4 h for MCV, persisting until the end of 11 hours. There was no change in MCHC and RDW. Regarding the leukogram, a significant increase in WBC was observed from 2 to 7 h, due to the increase in segmented neutrophils 2 to 8 h following feeding. Lymphocyte counts decreased significantly at 2 and 6 h following feeding. No alteration was observed in eosinophil, basophil, monocyte and platelet counts, as well as in MPV. From 5 h to 11 h after feeding, a significant decrease was seen on TPP. However, changes in hematological parameters did not exceed reference ranges for the canine species. Feeding dogs with industrialized feed caused statistically significant changes in erythrogram, leukogram and plasma protein content. While these changes do not seem to exceed reference values for the species in healthy animals, caution is warranted for sick animals with borderline values, in which these changes might be clinically important depending on the pathologic process.

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Section: Resultsmentioning

confidence: 53%

Diurnal variations in canine hematological parameters after commercial feed feeding

Costa

Silva

Oliveira

et al. 2020

Semina: Ciênc. Agrár.

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“…In this sense, previous studies have shown that exercise performed a few hours before the consumption of a HFM can attenuate oxidative damage and endothelial dysfunction induced by the meal (Bae et al 2001;Clegg et al 2007;Mc Clean et al 2007;Jenkins et al 2011;Krüger et al 2015). However, only few studies have investigated the effect of exercise intensity (Tyldum et al 2009;Gabriel et al 2012;Canale et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Effect of exercise intensity on postprandial lipemia, markers of oxidative stress, and endothelial function after a high-fat meal

Krüger

Farinha

Macedo

et al. 2016

Appl. Physiol. Nutr. Metab.

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The aim of this study was to compare the effects of 2 different exercise intensities on postprandial lipemia, oxidative stress markers, and endothelial function after a high-fat meal (HFM). Eleven young men completed 2-day trials in 3 conditions: rest, moderate-intensity exercise (MI-Exercise) and heavy-intensity exercise (HI-Exercise). Subjects performed an exercise bout or no exercise (Rest) on the evening of day 1. On the morning of day 2, an HFM was provided. Blood was sampled at fasting (0 h) and every hour from 1 to 5 h during the postprandial period for triacylglycerol (TAG), thiobarbituric acid reactive substance (TBARS), and nitrite/nitrate (NOx) concentrations. Flow-mediated dilatation (FMD) was also analyzed. TAG concentrations were reduced in exercise conditions compared with Rest during the postprandial period (P < 0.004). TAG incremental area under the curve (iAUC) was smaller after HI-Exercise compared with Rest (P = 0.012). TBARS concentrations were reduced in MI-Exercise compared with Rest (P < 0.041). FMD was higher in exercise conditions than Rest at 0 h (P < 0.02) and NOx concentrations were enhanced in MI-Exercise compared with Rest at 0 h (P < 0.01). These results suggest that acute exercise can reduce lipemia after an HFM. However, HI-Exercise showed to be more effective in reducing iAUC TAG, which might suggest higher protection against postprandial TAG enhancement. Conversely, MI-Exercise can be beneficial to attenuate the susceptibility of oxidative damage induced by an HFM and to increase endothelial function in the fasted state compared with Rest.

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“…This increase in the serum TG concentration and a probable inefficiency in the removal of triglyceride-rich lipoproteins (LRTs) can increase the inflammatory process and intensify the increase of reactive species in the postprandial period, consequently leading to oxidative damage [44]. In the present study, the biomarker of inflammatory activity TNFα was evaluated, which is closely associated with low-grade inflammation, systemic oxidative stress and the formation of atherosclerotic plaque in obese and dyslipidemic individuals [45,46].…”

Section: Discussionmentioning

confidence: 95%

Organic Beet Leaves and Stalk Juice Attenuates the Glutathione Peroxidase Increase Induced by High-Fat Meal in Dyslipidemic Patients: A Pilot Double-Blind, Randomized, Controlled Trial

et al. 2022

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The beet, including the leaves and stalk (BLS), is a vegetable with great antioxidant potential. The aim of this study was to evaluate the differences in the nutritional composition and the concentration of total phenolics between the organic and conventional BLS and to verify whether the ingestion of an organic BLS juice containing different concentrations of polyphenols modulated some biomarkers of oxidative stress after the ingestion of a high-fat meal in individuals with dyslipidemia. A controlled, randomized, double-blind, crossover clinical trial with a washout period of 1 week was carried out. A 12-h fasting blood sample was collected. Afterward, the participants consumed a high-fat meal, followed by the ingestion of a placebo or one of the organic BLS juices containing either 32.0 or 77.5 mg/100 mL of polyphenols. Blood samples were obtained 30, 60, 120 and 180 min after the first blood collection. The composition analysis showed that organic BLS had a better nutritional composition than conventional ones. The high-fat meal induced postprandial hypertriglyceridemia after 120 min (p < 0.001) and increased the concentration of malondialdehyde after 30 min (p < 0.001). In addition, there was a significant increase in GPx in 30 min (p = 0.026). This increase was attenuated in the group that received the highest dose of polyphenols when compared with the placebo after 30 min (p = 0.045). Therefore, the organic BLS juice containing 77.5 mg of polyphenols was efficient at modulating one of the postprandial mechanisms of enzymatic antioxidant protection in individuals with dyslipidemia.

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Estresse oxidativo e a função endotelial: efeitos do exercício físico associado à lipemia pós-prandial

Cited by 7 publications

References 61 publications

Diurnal variations in canine hematological parameters after commercial feed feeding

Diurnal variations in canine hematological parameters after commercial feed feeding

Effect of exercise intensity on postprandial lipemia, markers of oxidative stress, and endothelial function after a high-fat meal

Organic Beet Leaves and Stalk Juice Attenuates the Glutathione Peroxidase Increase Induced by High-Fat Meal in Dyslipidemic Patients: A Pilot Double-Blind, Randomized, Controlled Trial

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