Effects of Solanum lycopersicum L. (tomato) against isoniazid and rifampicin induced hepatotoxicity in wistar albino rats

Buabeid, Manal; Arafa, El‐Shaimaa A.; Rani, T. Sant; Ahmad, Fiaz-ud-Din; Ahmed, Hammad; Hassan, Waseem; Murtaza, Ghulam

doi:10.1590/1519-6984.254552

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…Extraction of the plant was carried out by following the method previously used (Buabeid et al, 2022) and Percentage yield was calculated. The obtained extract was then transferred in glass vials and stored in refrigerator at 4ºC for further use.…”

Section: Extraction Of Plant Materialsmentioning

confidence: 99%

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2023

Pak. J. Pharm. Sci.,

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The leaves of Ficus lyrata warb (Moraceae) is used to treat GI disorder such as diarrhea in folklore use. The aim of present research is to explore the antidiarrheal and antipyretic activity of methanolic extract of leaves of F. lyrata. The diarrhea was induced by using castor oil. The anti-pyretic effects were also explored on yeast induced pyrexia. The physicochemical analysis of powder such as (total ash, water soluble ash, acid insoluble ash, moisture content, foaming index and swelling index) along with organoleptic evaluation of leaf of F. lyrata in order to access the quality Purity of the substance was also done. The phytochemical analysis of methanolic extract of F. lyrata leaves confirmed the presence of polyphenols, tannins, terpenoids, cardiac glycosides, flavonoids and reducing sugar. The antidiarrheal activity of MEFL at 100 and 200 mg/kg body weight showed 62% and 76% reduction in defecation respectively. The decrease in intestinal fluid accumulation at same dose revealed 67.2% and 75% reduction in fluid accumulation in intestine of Wister albino rats. The methanolic extract of F. lyrata showed reduction in distance travelled by charcoal meal such as 54% and 72% at dose 100 and 200 mg/kg respectively. The antipyretic effect at a dose of 100 and 200 mg/kg showed significant reduction in temperature. The anti-diarrheal activity of the F. lyrata might be due to the presence of flavonoids.

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Section: Extraction Of Plant Materialsmentioning

confidence: 99%

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2023

Pak. J. Pharm. Sci.,

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Medicinal Plants of Solanum Species: The Promising Sources of Phyto-Insecticidal Compounds

Chidambaram

Alqahtani

Alghazwani

et al. 2022

Journal of Tropical Medicine

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Several medicinal plants have the potential to be a promising alternative pharmacological therapy for a variety of human illnesses. Many insects, including mosquitoes, are important vectors of deadly pathogens and parasites, which in the world’s growing human and animal populations can cause serious epidemics and pandemics. Medicinal plants continue to provide a large library of phytochemicals, which can be used to replace chemically synthesized insecticides, and utilization of herbal product-based insecticides is one of the best and safest alternatives for mosquito control. Identifying new effective phyto-derived insecticides is important to counter increasing insect resistance to synthetic compounds and provide a safer environment. Solanum genus (Solanaceae family or nightshades) comprises more than 2500 species, which are widely used as food and traditional medicine. All research publications on insecticidal properties of Solanaceae plants and their phytoconstituents against mosquitoes and other insects published up to July 2020 were systematically analyzed through PubMed/MEDLINE, Scopus, EBSCO, Europe PMC, and Google Scholar databases, with focus on species containing active phytoconstituents that are biodegradable and environmentally safe. The current state of knowledge on larvicidal plants of Solanum species, type of extracts, target insect species, type of effects, name of inhibiting bioactive compounds, and their lethal doses (LC50 and LC90) were reviewed in this study. These studies provide valuable information about the activity of various species of Solanum and their phytochemical diversity, as well as a roadmap for optimizing select compounds for botanical repellents against a variety of vectors that cause debilitating and life-threatening human diseases.

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Exploring biodiversity and ethnobotanical significance of Solanum species in Uzbekistan: unveiling the cultural wealth and ethnopharmacological uses

Gafforov,

Rašeta,

Zafar

et al. 2024

Front. Pharmacol.

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Despite its millennial existence and empirical documentation, the ethnological knowledge of herbs is a more recent phenomenon. The knowledge of their historical uses as food, medicine, source of income and small-scale businesses, and the sociological impacts are threatened due to the slow ethnobotanical research drive. Species of the genus Solanum have long been extensively used in folk medicine to treat various illnesses of humans since the dawn of civilization. All data were systematically obtained from papers, monographs, and books written in Uzbek, Russian, and English through various scientific online databases, including Google, Google Scholar, PubMed, Scopus, Semantic Scholar, Science Direct, and Web of Science using specific keywords focused on eight Solanum species. Eight native and non-native Solanum species as S. dulcamara L., S. lycopersicum L., S. melongena L., S. nigrum L., S. rostratum Dunal., S. sisymbriifolium Lam., S. tuberosum L., and S. villosum Mill. have been recorded in Uzbekistan of Central Asia. In this article we presented recently obtained data on the diversity, morphological characteristics, global distribution, habitat, population status, phenology, reproduction, pharmacology and phytochemistry of these Solanum species in Uzbekistan. Furthermore, relying on a combination of literature reviews and analyses from various scientific papers, we focus on food consumption coupled with global ethnobotanical and ethnopharmacological uses in human diseases of the Solanum species growing in Uzbekistan. Since the dawn of civilization, these eight cultivated and non-cultivated species of Solanum have provided sustainable resources of medicinal plants in Uzbekistan to prevent and treat various human diseases. Based on the collected data, it was shown that Solanum species have not been studied ethnobotanically and ethnomedicinally in Uzbekistan and it is necessary to conduct phytochemical and biotechnological research on them in the future. Traditional uses and scientific evaluation of Solanum indicate that S. nigrum, S. sisymbriifolium and S. tuberosum are one of the most widely used species in some parts of the world. Although considerable progress has been made to comprehend the chemical and biological properties of S. nigrum and S. tuberosum species, more research on the pharmacology and toxicology of these species is needed to ensure the safety, efficacy, and quality of their biologically active extracts and isolated bioactive compounds. Additionally, conducting additional research on the structure-activity relationship of certain isolated phytochemicals has the potential to enhance their biological efficacy and advance the scientific utilization of traditional applications of Solanum taxa.

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Effects of Solanum lycopersicum L. (tomato) against isoniazid and rifampicin induced hepatotoxicity in wistar albino rats

Cited by 4 publications

References 28 publications

Untitled

Untitled

Medicinal Plants of Solanum Species: The Promising Sources of Phyto-Insecticidal Compounds

Exploring biodiversity and ethnobotanical significance of Solanum species in Uzbekistan: unveiling the cultural wealth and ethnopharmacological uses

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