Anti-hyperglycemic and anti-hyperlipidemic effects of a methanolic extract of Debregeasia salicifolia in Alloxan-induced diabetic albino mice

Abstract

Diabetes mellitus (DM), an endocrine syndrome characterized by high blood glucose levels due to abrogated insulin activity. The existing treatments for DM have side effects and varying degrees of efficacy. Therefore, it is paramount that novel approaches be developed to enhance the management of DM. Therapeutic plants have been accredited as having comparatively high efficacy with fewer adverse effects. The current study aims to elucidate the phytochemical profile, anti-hyperlipidemic, and anti-diabetic effects of methanolic extract D. salicifolia (leaves) in Alloxan-induced diabetic mice. Alloxan was injected intraperitoneally (150 mg kg-1, b.w), to induced diabetes in mice. The mice were divided into three groups (n=10). Group 1 (normal control) received normal food and purified water, Group II (diabetic control) received regular feed and clean water and group III (diabetic treated) received a methanolic extract of the plant (300 mg kg-1) for 28 days with a typical diet and clean water throughout the experiment. Blood samples were collected to checked serum glucose and concentration of LDL, TC, TG. The extract demonstrated significant antihyperglycemic activity (P<0.05), whereas improvements in mice's body weight and lipid profiles were observed after treatment with the extract. This study establishes that the extract has high efficacy with comparatively less toxicity that can be used for DM management.

Phytochemicals, Antioxidant, and Antidiabetic Effects of Ranunculus hirtellus Aerial Parts and Roots: Methanol and Aqueous Extracts

“…hirtellus suggest their potential in treating various ailments. These compounds have been reported in several studies from other medicinal plants. , …”

Anais Do I Congresso Luso-Brasileiro De Saúde Coletiva (On-Line) – Resumos Expandidos

“…O Diabetes Mellitus é uma doença endócrina caracterizada por elevados níveis de glicose no sangue, devido a irregularidades na atividade da insulina (KHAN B, et al, 2023) e influencia diretamente o contexto odontológico, como o tipo de anestésico a ser utilizado, os medicamentos receitados, as complicações que podem ocorrer durante o tratamento e, em especial, dificultando o processo de cicatrização após procedimentos cirúrgicos na cavidade oral (FREITAS L, et al, 2021). De acordo com alguns estudos, de 3 a 4% dos pacientes que buscam tratamento odontológico são diabéticos, levando a manifestações bucais que podem afetar o tratamento cirúrgico e a posterior cicatrização da região tecidual (ASNAASHARI M, et al,2015), além de alterações bucais como: hipoplasia, hipocalcificação do esmalte, diminuição do fluxo e aumento da acidez e da viscosidade salivar, que são fatores de risco para cárie, podendo também apresentar doença periodontal e xerostomia (MENDES V C, et al,2016).…”