Challenges of nanotechnology in cosmetic permeation with caffeine

Abstract

The evolution of beauty market and personal care is constant in Brazil as well in the rest of the world. Technological advances have brought up nanotechnology to the cosmetological field, employing active principles at atoms enveloped by vesicles, in order to take the active principle precisely to the target tissue to optimize the results achieved because of the considerable ease to cross skin barriers. Manufacturing of nanotechnology cosmetics is confronted with low absorption capacity. One of the many active principle found in cosmetic industry is caffeine, a pseudoalkaloid from the xanthine group used as a stimulant with the mechanism of the lipolytic action. This active is widely used in a esthetics and cosmetics field in treatments involving dysfunctions such as localized fat and fibroedema geloid. To work out perfectly, the principle active need to interact and create a set of factors that includes lipolysis intensification. The caffeine encapsulation in gel-based nanocosmetics has the purpose of taking this active up to the adipocyte, the target cell, for mentioned dysfunctions treatment. Thus, we aim to present a review of how has been, the use of caffeine in the production of cosmetics.

Nanocosmetics and Skin Health: A Comprehensive Review of Nanomaterials in Cosmetic Formulations

“…Humectants aid in hydrating the skin by drawing in and holding onto moisture. Propylene glycol, hyaluronic acid, and glycerin are examples of common humectants [ 4 ].…”

Development of SEDDS formulation containing caffeine for dermal delivery

“…An arsenal of treatments for cellulite is available, the main ones being non-invasive and non-surgical, such as the use of topical pharmacological agents, and instrumental mechanisms, like therapy with radiofrequency and laser devices [5][6][7][8]. Anti-cellulite cosmetics are composed of active substances whose potential effects include lipolysis, lymphatic drainage, stimulation of peripheral microcirculation, reduction of oedema and stimulation of collagen production [9,10].…”

“…This stimulates lipolysis of adipose tissue, reducing the accumulation of fat that occurs in cellulite and consequently improving the appearance of the skin [10,11]. CAF also has a stimulating effect on microcirculation by reducing the formation of free radicals [9,10].…”

“…Nanotechnology in cosmetics has demonstrated excellent protection against chemical and enzymatic degradation, resulting in increased stability, controlled release and low toxicity. Additionally, smaller doses can be included due to vectorization of the active [9,13,14]. The physicochemical properties of the nanomaterials used make them desirable carriers for cosmetic application, as they have a high retention time when applied to the skin, are more durable, have deeper penetration and have a targeted action [9,15].…”

“…Additionally, smaller doses can be included due to vectorization of the active [9,13,14]. The physicochemical properties of the nanomaterials used make them desirable carriers for cosmetic application, as they have a high retention time when applied to the skin, are more durable, have deeper penetration and have a targeted action [9,15].…”