American visceral leishmaniasis in a state of northeastern Brazil: clinical, epidemiological and laboratory aspects

Ferreira, Jussara Rocha; Silva, K. M.; Almeida, Mariana Silva Gois de; Gomes, Diogo; Cavalcanti, Maria Taciana Holanda; Ferreira-Júnior, G. C.; Alves, L. C.; Brayner, Fábio André; Rocha, Thiago José Matos

doi:10.1590/1519-6984.238383

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…The continuous surveillance of VL is a key issue for its control, as it allows the evaluation of the past and present in order to reduce the future burden of this important disease (Ferreira et al, 2021). Furthermore, this study reinforces the need for actions that minimize the problem of underreporting.…”

Section: Discussionsupporting

confidence: 61%

Prediction of visceral leishmaniasis incidence using the Seasonal Autoregressive Integrated Moving Average model (SARIMA) in the state of Maranhão, Brazil

et al. 2024

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Visceral leishmaniasis (VL) is an infectious disease predominant in countries located in the tropics. The prediction of occurrence of infectious diseases through epidemiologic modeling has revealed to be an important tool in the understanding of its occurrence dynamic. The objective of this study was to develop a forecasting model for the incidence of VL in Maranhão using the Seasonal Autoregressive Integrated Moving Average model (SARIMA). We collected monthly data regarding VL cases from the National Disease Notification System (SINAN) corresponding to the period between 2001 and 2018. The Box-Jenkins method was applied in order to adjust a SARIMA prediction model for VL general incidence and by sex (male or female) for the period between January 2019 and December 2013. For 216 months of this time series, 10,431 cases of VL were notified in Maranhão, with an average of 579 cases per year. With regard to age range, there was a higher incidence among the pediatric public (0 to 14 years of age). There was a predominance in male cases, 6437 (61.71%). The Box-Pierce test figures for overall, male and female genders supported by the results of the Ljung-Box test suggest that the autocorrelations of residual values act as white noise. Regarding monthly occurrences in general and by gender, the SARIMA models (2,0,0) (2,0,0), (0,1,1) (0,1,1) and (0,1,1) (2, 0, 0) were the ones that mostly adjusted to the data respectively. The model SARIMA has proven to be an adequate tool for predicting and analyzing the trends in VL incidence in Maranhão. The time variation determination and its prediction are decisive in providing guidance in health measure intervention.

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Section: Discussionsupporting

confidence: 61%

Prediction of visceral leishmaniasis incidence using the Seasonal Autoregressive Integrated Moving Average model (SARIMA) in the state of Maranhão, Brazil

et al. 2024

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Spatial-temporal distribution of visceral leishmaniasis in Rio de Janeiro, Brazil, 2001–2020: expansion and challenges

Vasconcelos,

Bedoya-Pacheco,

Cunha e Silva

et al. 2024

Transactions of the Royal Society of Tropical Medicine and Hygiene

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Background Visceral leishmaniasis results from complex interactions among humans, dogs and environment. Brazil accounts for 97% of cases in the Americas. Methods Twenty years (2001–2020) of the endemic disease in the state of Rio de Janeiro were studied. Incidence, lethality, sociodemographic and clinical characteristics were investigated, complemented with spatial methodologies (kernel and clusters). Results Ninety-seven human cases and 625 dogs were reported. Of the 92 cities, 22 were human endemic areas. The state had a low incidence level (0.6 per 100 000). Lethality was higher compared with the Brazilian average. More than 90% of infections occurred in urban areas. Most cases (66%) occurred in men. The predominant age groups were 0–4 y (28.7%) and 20–39 y (32.9%). Fever (89.5%), splenomegaly (83.2%) and hepatomegaly (76.8%) were the main clinical manifestations. Spatial analysis showed a displacement of the human endemic: in the first decade (2001–2010), cases were concentrated in the Metropolitan region, and in the second decade (2011–2020) in the Médio Paraíba region of the state. Most of the endemic area (56.4%) had canine infections without reported human cases. Conclusions Disorderly urbanisation and precarious living conditions favour the transmission of the disease. Changes in the environment and migratory processes contribute to its expansion.

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Apresentação clínica da leishmaniose visceral: uma revisão integrativa

Pessoa,

Guterres,

Andrade

et al. 2024

Cuad. Ed. Desar.

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Introdução: A Leishmaniose visceral (LV) é uma doença parasitária causada pelos protozoários do gênero Leishmania. Ela é transmitida pelos insetos da espécie Lutzomyia longipalpis, conhecidos, no Brasil, como mosquito-palha, sendo o cão o reservatório mais comum do protozoário. O Brasil possui cerca de 96% de todos os casos de LV na América. Os principais sintomas que acometem um paciente com suspeita de LV são: febre baixa e de longa duração, caquexia, linfadenopatia, hepatoesplenomegalia, astenia e anemia. Porém, a confirmação diagnóstica da doença deve ser feita através de exames parasitológicos e imunológicos. Desenvolvimento: Fez-se uma busca integrativa em bibliotecas virtuais utilizando “Qual é a apresentação clínica típica da Leishmaniose Visceral?” como pergunta norteadora e selecionando apenas artigos publicados nos últimos 10 anos (2013-2022) com estruturação metodológica baseada no PRISMA flow diagram. Assim, dos 23 estudos selecionados, os sinais mais comuns foram, respectivamente: febre, esplenomegalia e palidez. Conclusões: devido ao seu caráter endêmico no Brasil, o quadro sintomatológico deve ser bem definido para que seja possível o tratamento precoce da LV. Apesar da febre e da esplenomegalia serem os sintomas mais comuns da doença, outros achados semiológicos não devem ser desconsiderados, o que permitirá uma terapêutica eficaz, evitando complicações maiores, inclusive óbitos.

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American visceral leishmaniasis in a state of northeastern Brazil: clinical, epidemiological and laboratory aspects

Cited by 3 publications

References 24 publications

Prediction of visceral leishmaniasis incidence using the Seasonal Autoregressive Integrated Moving Average model (SARIMA) in the state of Maranhão, Brazil

Prediction of visceral leishmaniasis incidence using the Seasonal Autoregressive Integrated Moving Average model (SARIMA) in the state of Maranhão, Brazil

Spatial-temporal distribution of visceral leishmaniasis in Rio de Janeiro, Brazil, 2001–2020: expansion and challenges

Apresentação clínica da leishmaniose visceral: uma revisão integrativa

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