“…RV infection-induced cytokines, such as IL-5, IL-13, IL-25, and IL-33, were associated with persistent and severe asthma [ 78 ], and the serum levels of eosinophil cationic protein (ECP), IL-5, IL-6, and IP-10 were elevated in RV-infected children with wheezing [ 79 , 80 ]. Furthermore, sputum IL-1β, IL-5, IL-13, IL-25, and IL-33 levels, serum IL-6, IL-8, TNF-α, and IP-10 levels, plasma fibrinogen levels and the number of peripheral blood eosinophils were elevated in patients with RV infection-exacerbated COPD [ 19 , 20 , 67 , 81 ].…”