Epidemiological aspects of human and canine visceral leishmaniasis in State of Alagoas, Northeast, Brazil

Rocha, Mabel Alencar do Nascimento; Rocha, Thiago José Matos; Ribeiro, Correia; Abreu, Silvio Romero Oliveira

doi:10.1590/1519-6984.166622

Cited by 25 publications

(27 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…; there was also a reduction in the number of neighborhoods with incidence rates greater than 15 cases per 100,000 inhab. This falling trend was also found in the state of Alagoas, in 2013, when VL incidence in humans that year was the lowest in the study period from 2007 to 2013 14 .…”

Section: Discussionsupporting

confidence: 70%

Leishmaniose visceral: distribuição temporal e espacial em Fortaleza, Ceará, 2007-2017

Almeida

Cavalcante

Moreno

et al. 2020

Epidemiol. Serv. Saúde

View full text Add to dashboard Cite

Resumo Objetivo: Analisar a tendência temporal e descrever a distribuição espacial da leishmaniose visceral (LV) em Fortaleza, 2007-2017. Métodos: Estudo ecológico, mediante regressão temporal segmentada e mapeamento temático. Resultados: No período 2007-2017, foram confirmados 1.660 casos novos e 97 óbitos. No período 2007-2010, a incidência foi ascendente (variação percentual anual [Annual Percent Change], APC=8,7% - IC95% -3,3;34,1), enquanto a mortalidade (APC=-25,9 - IC95% -48,5; -10,6) e a letalidade (APC=-33,0 - IC95% -53,7;-17,6), descendentes. No período 2010-2015, a incidência reduziu (APC=-15,8 - IC95% -25,1;-4,0), mas a mortalidade (APC=18,7 - IC95% 9,4;50,6) e a letalidade (APC=40,1 - IC95% 22,5;72,0) apresentaram tendência de crescimento. Em 2015-2017, decresceram a incidência (APC=-24,6 - IC95% -36,2;-10,3) e a mortalidade (APC= -44,6 - IC95% -58,8;-17,6); a letalidade se manteve estável (APC=-13,5 - IC95% -38,7;3,8). Houve concentração de bairros com incidência elevada na região oeste da cidade; porém, a mortalidade e a letalidade não apresentaram padrões espaciais definidos. Conclusão: A LV é endêmica em Fortaleza, embora tenha havido declínio no último triênio estudado.

show abstract

Section: Discussionsupporting

confidence: 70%

Leishmaniose visceral: distribuição temporal e espacial em Fortaleza, Ceará, 2007-2017

Almeida

Cavalcante

Moreno

et al. 2020

Epidemiol. Serv. Saúde

View full text Add to dashboard Cite

show abstract

“…The possible ways of dispersion and longitudinal changes in the distribution of vectors during these initial periods were also studied in other cities of the region [16–19]. Despite the expected, cases of HVL tend to decrease in older foci in Argentina [20] without systematic control interventions that could explain this pattern [21,22]. In turn, little is known about CVL changes in prevalence patterns during the same period.…”

Section: Introductionmentioning

confidence: 99%

Twice upon a time: The progression of canine visceral leishmaniasis in an Argentinean city

et al. 2019

View full text Add to dashboard Cite

Canine Visceral Leishmaniasis (CVL) prevalence, spatial distribution and associated factors were assessed in four locations in Iguazú department in 2014 and in Puerto Iguazú city again in 2018. The city areas were divided into a grid of 400x400m cells. All cells were sampled in 2014 and a random subsampling was developed in 2018. In each cell, five dogs clustered in a ‘critical scenario’ (prone to have vectors) were sampled. A rapid immunochromatographic dipstick was used to detect antibodies against Leishmania infantum , confirming by lymph node smears observation and PCR. For Puerto Iguazú, Generalized Linear Models (GLMs) were constructed considering environmental, dog and clinical variables. Pearson's Chi square and Fisher's exact tests were employed to evaluate the association between CVL, dog clinical signs and infestation with other parasites. Cartographic outputs were made and Moran's I indices were calculated as spatial autocorrelation indicators. CVL prevalence rates were 26.18% in 2014 and 17.50% in 2018. No associations were established in environmental models, but dog age and repellent use were significant when running 2014 dog models. Clinical models showed significant associations between seropositive dogs and ophthalmological, dermal signs and onychogryphosis in 2014. In 2018, only adenomegaly was associated. The results of global Moran´s I were not significant but regarding local analysis, six sites in 2014 and one in 2018 presented autocorrelation with neighboring sites. The decrease in CVL prevalence may be associated to transmission stabilization, which could explain the lack of associations with dog-related variables. Further, spatial distribution of CVL is a poor evidence for design of transmission control measures but could be important in case of intensive parasite circulation or when the first autochthonous cases appear. For control success, sensitivity of diagnostic methods, political will and adequate material resources remain critical. Modeling of multiple variables will be required to identify factors that drive disease stabilization/destabilization.

show abstract

“…In the American continent, the control of metazoonotic canine visceral leishmaniasis (CVL) is crucial for reducing the occurrence of human visceral leishmaniasis (HVL); the dog is the main reservoir for Leishmania ( Leishmania ) infantum , the etiological agent of CVL in urban areas. 1 , 2 …”

mentioning

confidence: 99%

Improving the reference standard for the diagnosis of canine visceral leishmaniasis: a challenge for current and future tests

Teixeira

Silva

Vital

et al. 2019

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

BACKGROUND Studies aimed at validating canine visceral leishmaniasis diagnostic tests present heterogeneous results regarding test accuracy, partly due to divergences in reference standards used and different infection evolution periods in animals. OBJECTIVE This study aimed to evaluate the accuracy of the rapid test-dual path platform (TR-DPP) (Biomanguinhos®), EIE-Leishmaniose-Visceral-Canina-Biomanguinhos (EIE-LVC) (Biomanguinhos®), enzyme-linked immunosorbent assay (ELISA) rK39 (in-house), and the direct agglutination test (DAT- Canis ) against a reference standard comprising parasitological and molecular techniques. METHODS A phase II/III validation study was carried out in sample sera from 123 predominantly asymptomatic dogs living in an area endemic for visceral leishmaniasis. FINDINGS Sixty-nine (56.1%) animals were considered infected according to the reference standard. For each test, the sensitivity and specificity, respectively, were as follows: TR-DPP, 21.74% [confidence interval (CI)95% 13.64% to 32.82%] and 92.59% (CI95% 82.45% to 97.08%); EIE-LVC, 11.59% (CI95% 5.9% to 21.25%) and 90.74% (CI95% 80.09% to 95.98%); ELISA rK39, 37.68% (CI95% 27.18% to 49.48%) and 83.33% (CI95% 71.26% to 90.98%); and DAT- Canis , 18.84% (CI95% 11.35% to 29.61%) and 96.30% (CI95% 87.46% to 98.98%). CONCLUSION We concluded that improving the sensitivity of serum testing for diagnosing asymptomatic dogs must constitute a priority in the process of developing new diagnostic tests to be used in the visceral leishmaniasis control program in Brazil.

show abstract

Epidemiological aspects of human and canine visceral leishmaniasis in State of Alagoas, Northeast, Brazil

Cited by 25 publications

References 24 publications

Leishmaniose visceral: distribuição temporal e espacial em Fortaleza, Ceará, 2007-2017

Leishmaniose visceral: distribuição temporal e espacial em Fortaleza, Ceará, 2007-2017

Twice upon a time: The progression of canine visceral leishmaniasis in an Argentinean city

Improving the reference standard for the diagnosis of canine visceral leishmaniasis: a challenge for current and future tests

Contact Info

Product

Resources

About