Effectiveness of ginger in reducing metabolic levels in people with diabetes: a randomized clinical trial

Abstract

Objective: to evaluate the effectiveness of ginge (Zingiber officinale) in reducing blood sugar and lipid levels in people with type 2 diabetes. Method: a randomized and double-blind clinical trial conducted with people with type 2 diabetes in primary care facilities. The study included individuals aged between 20 and 80 years old, using oral antidiabetic drugs and with HbA1c levels between 6.0% and 10%. The participants were paired 1:1, allocated in two distinct groups, and randomized in blocks, based on their HbA1c levels. In the experimental group, the participants used 1.2g of ginger and, in the control group, 1.2g of placebo, daily for 90 days. The primary outcome was a reduction in fasting blood sugar and HbA1c, and the secondary outcome was a reduction in lipids and HOMA-IR. 103 individuals completed the study, 47 in the experimental group and 56 in the control group. Results: the participants in the experimental group showed a greater reduction in the blood glucose and total cholesterol values compared to the control group. Conclusion: the use of ginger can help in the treatment of people with diabetes, and data support the inclusion of this herbal drug in the clinical practice of nurses. RBR-2rt2wy

Medicinal chemistry inspired by ginger: exploring the chemical space around 6-gingerol

“…Results from a randomized clinical trial on the possible antidiabetic potential of ginger consumption suggested a decrease in blood glucose and cholesterol levels. 92 …”

p53 Rather Than β-Catenin Mediated the Combined Hypoglycemic Effect of Cinnamomum cassia (L.) and Zingiber officinale Roscoe in the Streptozotocin-Induced Diabetic Model

“…It was reported that cinnamon improved anthropometric parameters, lipid profile, and glycemic indices of type II diabetic patients ( Zare et al, 2019 ). Although the hypoglycemic effect of ginger ( Akash et al, 2015 ; Carvalho et al, 2020 ) and cinnamon ( Sahib, 2016 ; Santos and da Silva, 2018 ) administrated separately were frequently studied in both animal and human, the hypoglycemic effect of combined ginger and cinnamon administration was not sufficiently studied. Therefore, this study was designed to evaluate the effect of the combined administration of ginger and cinnamon on the glycemic, antioxidant capacity, and the structure of pancreatic islet cells in an animal model of diabetes mellitus compared to metformin and to explore the mechanism behind this effect.…”

Endothelial Function and Postprandial Glucose Control in Response to Test-Meals Containing Herbs and Spices in Adults With Overweight/Obesity

“…Medagama et al (42) reviewed the evidence for cinnamon and reported favorable effects of cinnamon on glucose and lipids homeostasis in individuals with T2DM. Other studies report the glucose and lipid-lowering effect of ginger and rosemary supplementation in people with T2DM (43)(44)(45)(46). Overall, data are accumulating to support metabolic benefits of H/S in humans with T2DM, although very little is known about H/S intake in at-risk individuals as a preventative strategy in disease development/transition (47)(48)(49).…”