Nurse empowerment through Pharmacogenetics

Abstract

Objective: to verify the existence of elements that justify the use of pharmacogenetics by the Brazilian nurse. Method: this is a quantitative, cross-sectional, observational, descriptive study, whose final sample was 67 individuals. The participants were healthy at the time of the study and reported a history of previous use and the occurrence of adverse effects by drugs commonly used and metabolized by CYP2C9. We collected 4 mL of venous blood for subsequent DNA extraction by salting out method and genotyping of the CYP2C9*2 and CYP2C9*3 polymorphisms, using Polymerase Chain Reaction in real time using Taqman assays. Results: the use of drugs metabolized by CYP2C9 was frequent (more than 75% of the individuals have already used between 2 or 4 of these drugs). Regarding adverse events, there were 19 perceived symptomatic occurrences associated with drugs metabolized by CYP2C9. The allele frequency of the polymorphism * 2 and * 3 in the population studied was 11.1% and 7.5%, respectively, and there was a coincidence between the presence of alleles of low enzyme activity and the occurrence of adverse effects. Conclusion: there are elements that justify the adoption of pharmacogenetics in the nursing care to reduce the occurrence of adverse reactions to drugs metabolized by CYP2C9.

Genetics and Genomics Teaching in Nursing Programs in a Latin American Country

“…In the multidisciplinary team, nurses occupy a prominent position since they are in direct and constant contact with the individuals under their care [ 13 , 14 , 15 , 53 ]. In some areas, such as oncology, genetics and genomics are intrinsically related to nursing care through health education activities, counseling, and pharmacogenomics translation into clinical practice [ 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ].…”

Reações adversas a medicamentos em hospital privado da rede sentinela

“…Tais eventos desastrosos relatados contribuíram para que muitos países, agências reguladoras e organizações desenvolvessem ações voltadas para a segurança dos medicamentos, ou seja, ações de farmacovigilância 7 . Atualmente, nos Estados Unidos da América (EUA), estima-se que as RAM figuram entre as maiores causas de mortalidade e elevam o percentual de internações hospitalares em torno ou acima de 10%; e em alguns países, de 15 a 20% do orçamento hospitalar é aplicado em função de complicações decorrentes do uso de medicamentos 6,8…”