Development of a clinical protocol for detection of cervical cancer precursor lesions

Abstract

Objective:to develop and validate the content of a clinical protocol aimed at prevention of cervical cancer in primary care. Method:technological research according to the steps: (1) submission of the project to the research ethics committee; (2) bibliographic survey; (3) elaboration of the clinical protocol; and (4) content validation. In the third step, the information was collected through bibliographic research and gynecology specialists were consulted. For the final step, four judges were selected to evaluate the clinical protocol according to AGREE 2. Domains that reached the minimum level of agreement of 75% in the scores were considered validated. Results:the scores obtained in each domain of the instrument were as follows: domain 1 (scope and purpose) = 87.5%; domain 2 (stakeholder involvement) = 83.3%; domain 3 (development rigor) = 79.7%; domain 4 (clarity of presentation) = 76.3%; domain 5 (applicability) = 78.1%; and domain 6 (editorial independence) = 85.4. Conclusion:the clinical protocol proved to be a validated material with scores above the minimum required. The protocol obtained positive recommendations with modifications and went through adjustments in order to make it more effective.

Validation methods of nursing protocols: an integrative review

“…From reading the articles, data emerged concerning protocol creation. All articles mention the literature review as part of protocol creation, be it a simple or structured literature review, such as integrative (12)(13)(14)(15) and systematic (16)(17) reviews, with emphasis on scoping reviews (4,6) . In some articles, literature review is associated with another type of data collection, such as interviews (18)(19)(20)(21) and group discussions (22)(23)(24) .…”

“…Concerning data collection instruments used for validation, only two studies used a standardized tool (14,21) , and the others created their own instrument according to different validation criteria according to the adopted framework. The aforementioned studies used AGREE II (Appraisal of Guidelines for Research & Evaluation).…”

“…Fehring (47) proposed a scoring model for the criteria for defining experts to validate nursing diagnoses, being cited by two authors in this review (6,28) . Two authors cited Jasper (13)(14) , who published an article in 1994 seeking to define the concept and criteria for an "expert" in nursing.…”

“…Desenvolvimento de protocolo clínico para detecção de lesões precursoras do câncer de colo uterino (14) 2018 Brazil…”

Effect of arsenic trioxide on cervical cancer and its mechanisms

“…There are ~500,000 new cases annually worldwide, where the incidence is rising annually with diagnosis being common among younger women ( 2 , 3 ). Surgery plus radiotherapy can significantly improve the treatment effect of early-stage cancer, but for the late stage, the treatment effect of patients with relapse and metastasis remains at the bottleneck stage, and the 1-year survival rate of patients with late-stage cancer is <20% ( 4 , 5 ). Therefore, it is important to identify the molecular pathogenesis of cervical cancer, in order to develop complementary or substitute treatment methods, as well as more effective strategies to prevent cervical cancer, which will be of great theoretical and practical significance to improve the quality of life of patients with this disease worldwide.…”