Electrochemical Sensor for Doping Corticosteroids in Sports

Abstract

Introduction: Identifying and measuring the concentration of Triamcinolone (TA) in biological fluids is essential, especially for patients receiving intensive antibiotic medication. Objective: Make a sensor for electrochemical detection of Triamcinolone (TA) as an anabolic steroid in sports using copper oxide nanomaterials-reduced graphene oxide nanoparticles (CuNPs/rGO). Method: After preparing rGO nanoparticles on a glassy carbon electrode (GCE) using the modified Hummers technique, Cu NPs were deposited on rGO/GCE. The applicability of Cu NPs/rGO/GCE was investigated to determine the TA concentration in a real sample that had been prepared. Results: The deposited irregular Cu NPs evidenced a diameter of about 80 nm, in agreement with SEM morphological investigations. Amperometric studies revealed that the linear range, detection limits, and sensitivity of CuNPs/rGO/GCE as a TA sensor were 10 to 80 µM, 10nM, and 0.06584 µA/µM, respectively. Conclusion: The results revealed that the RSD and recovery values were valid, providing adequate quality and reliability for practical analysis of real samples using Cu NPS/rGO/GCE. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

Fisiologia Do Esporte: O Uso De Esteroides Anabolizantes

“…São prescritos principalmente para controlar processos inflamatórios em condições médicas como asma, artrite e distúrbios cutâneos. Vale destacar que esses medicamentos apresentam diferentes graus de efeitos anabólicos e são detectados em doping em algumas competições (MORALES-PUEBLA et al, 2023;SKOLNIK et al, 2023;XU, 2023).…”