Ace/Actn3 Genetic Polymorphisms and Athletic Performance of Female Soccer Players`

Jeremic, Dejan; Mačužić, Ivana Živanović; Vulović, Maja; Stevanović, Jelena; Radovanović, Dragan; Varjacic, Vladimir; Djordjevic, Dusica

doi:10.1590/1517-869220192501187684

Cited by 8 publications

(11 citation statements)

References 29 publications

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“…Concordantly, our findings are in agreement with the studies made in Australia and Turkey (Ulucan et al, 2015;Jacob et al, 2018). In a Serbian study with female soccer players, there was a high prevalence of the DD genotype, suggesting that individuals with this genotype tend to perform better in soccer (Jeremic et al, 2019).…”

Section: Discussionsupporting

confidence: 92%

Research Article Assessment of effects of the genetic polymorphisms on soccer athletes

Menezes¹,

Gingozac²,

Oliveira³

et al. 2019

Genet. Mol. Res.

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Several genes have been identified as important in athletic performance. The angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism has been related to improvements in performance and exercise duration. However, there are large divergences among studies on the influence of ACE I/D polymorphism on physical performance. Other studies have demonstrated that strenuous exercise generally overloads the endogenous antioxidant system's capacity, leading to oxidative damage to muscles and other tissues in athletes. Few studies have reported significant associations between glutathione S-transferase (GST) deletion polymorphisms and resistance performance in athletes. We examined the effects of ACE I/D and GST deletion polymorphisms in young soccer players in central Brazil. We included 65 soccer players from under-20 (18 to 20 years old) soccer ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 18 (2): gmr18192 W.C.F. Menezes et al. 2 teams and 60 non-athletes in a case-control study. All subjects had their physical performance investigated through the Running-based Anaerobic Sprint Test (RAST). Genotyping was performed using real-time PCR. We found that the I/D genotype was significantly more frequent in athletes compared with the non-athletes. Individuals with the ID and DD genotypes had an approximately 3.13-fold and 4.37-fold increase in strength and power-orientated performance, respectively. The DD genotype in athletes presented RAST-test results considered as excellent to good when compared with non-athletes. When we examined a possible association of the GST deletion polymorphisms and RAST test, we found no influence on athletic performance. We did find association between ACE I/D polymorphism and athletic performance. However, there was no association between GST polymorphisms and risk of oxidative damage in the muscles. Our findings may help to select young players with the most favorable genetic potential to succeed as soccer athletes.

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Section: Discussionsupporting

confidence: 92%

Research Article Assessment of effects of the genetic polymorphisms on soccer athletes

Menezes¹,

Gingozac²,

Oliveira³

et al. 2019

Genet. Mol. Res.

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show abstract

“…The most studied polymorphisms were ACTN3 [1,15,20], ACE [20,21], AGT and AMPD [20], MTHFR [22], and GST [21]. Overall, 4 studies included young male football players and 1 involved youth female football players [1]. Additionally, 4 studies assessed endurance performance by using shuttle runs and 1 did not present any test information [15] ( Table 1).…”

Section: Performancementioning

confidence: 99%

“…The association between the ACE and ACTN3 R577X polymorphisms and performance endurance was assessed in 4 studies [1,15,20,21]. Dinc et al [22] investigated athletic performance and homocysteine levels in relation to the MTHFR C677T mutation as well as its relationship with other cardiac risk factors.…”

Section: Performancementioning

confidence: 99%

“…Likewise, evidence suggests that athletes with the DD genotype also have an anaerobic power [21]. However, others failed to identify any significant relationship between ACE/ACTN3 polymorphisms and performance in young female football players [1]. Previous research suggests no association between the GSTM1/ GSTT1 polymorphisms and increased athletic performance [21].…”

Section: Endurancementioning

confidence: 99%

“…Over the last 20 years, there has been an exponential increase in interest regarding genetic factors that are responsible for all aspects of sporting performance [1]. Indeed, this premise applies to a number of different sports, though football, pertaining to its worldwide popularity, has received considerable research attention [2,3].…”

Section: Introductionmentioning

confidence: 99%

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Genetic influence on football performance - a systematic review

Sarmento¹,

Marques²,

Field³

et al. 2020

Hum Mov.

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Purpose. To systematically review and organise the available literature devoted to the topic of genetics and performance in football. Methods. A systematic search was conducted in accordance with the PRISMA guidelines in Web of Science, SPORTDiscus, and PubMed for original research published before October 2019. The following keywords were entered: 'Soccer' OR 'Football' AND 'Genetic' OR 'Epigenic' OR 'Powergene' OR 'Genomic' OR 'Genotype' OR 'Polymorphism' OR 'Genetic marker'. Articles were screened by using pre-defined selection criteria, and methodological quality was assessed independently by 2 authors. Results. The electronic searches yielded 872 articles, and after the screening process, a total of 38 studies met the eligibility criteria and were subsequently included for review. Conclusions. The reviewed studies identified the most frequently addressed topics in this area of research: (1) performancerelated genes; (2) injury-related genes; (3) body composition-related genes; and (4) cardiac adaptations. This area of research is still at an early stage, and there is a need for studies to develop knowledge of genetics and its link with physical, technical, and cognitive performance in football with a view to facilitating talent identification in young players.

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Genetic association research in football: A systematic review

McAuley

Hughes

Tsaprouni

et al. 2020

European Journal of Sport Science

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Genetic variation is responsible for a large amount of the inter-individual performance disparities seen in sport. As such, in the last ten years genetic association studies have become more common; with one of the most frequently researched sports being football. However, the progress and methodological rigor of genetic association research in football is yet to be evaluated. Therefore, the aim of this paper was to identify and evaluate all genetic association studies involving football players and outline where and how future research should be directed.Firstly, a systematic search was conducted in the Pubmed and SPORTDiscus databases, which identified 80 eligible studies. Progression analysis revealed that 103 distinct genes have been investigated across multiple disciplines; however, research has predominately focused on the association of the ACTN3 or ACE gene. Furthermore, 55% of the total studies have been published within the last four years; showcasing that genetic association research in football is increasing at a substantial rate. However, there are several methodological inconsistencies which hinder research implications, such as; inadequate description or omission of ethnicity and onfield positions. Furthermore, there is a limited amount of research on several key areas crucial to footballing performance, in particular; psychological related traits. Moving forward, improved research designs, larger sample sizes, and the utilisation of genome-wide and polygenic profiling approaches are recommended. Finally, we introduce the Football Gene Project, which aims to address several of these limitations and ultimately facilitate greater individualised athlete development within football.

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Ace/Actn3 Genetic Polymorphisms and Athletic Performance of Female Soccer Players`

Cited by 8 publications

References 29 publications

Research Article Assessment of effects of the genetic polymorphisms on soccer athletes

Research Article Assessment of effects of the genetic polymorphisms on soccer athletes

Genetic influence on football performance - a systematic review

Genetic association research in football: A systematic review

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