Comparison of the Efficacy of Losartan, Hydrocortisone and Acetylsalicylic Acid (Asa) in Preventing the Development of Fibrous Scar Tissue in Skeletal Muscle
Abstract:Objective: To analyze fibrous scar tissue inhibition capacity with the use of losartan, hydrocortisone and acetylsalicylic acid. Method: The sample consisted of 120 male heterogeneic Wistar rats with a muscle laceration model. The rats were divided into four groups of 30 animals each: control group, losartan group, ASA group and hydrocortisone group. The animals were anesthetized and a 2.5 cm longitudinal incision was made in the left thoracolumbar paravertebral region. The muscles were subjected to a Grade I… Show more
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