The pathophysiology of high-lethality suicide attempts: a vital area of suicide research

Sher, Leo

doi:10.1590/1516-4446-2021-2281

Cited by 2 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A high-lethality suicide attempt can be considered a close proxy of completed suicide. Therefore, the study of its neurobiology may shed light on the pathophysiology of suicide [ 30 ]. Identifying people who are more at risk of attempting suicide with a high-lethality method is thus crucial, not only for the physical implications but also for a better understanding of suicidal behaviors.…”

Section: Discussionmentioning

confidence: 99%

“…However, to our knowledge, no study has attempted to estimate a cut-off to distinguish between high- to low-lethality suicide attempts. The study of suicide attempts with high-lethality is fundamental as they can be considered proxies of completed suicide [ 30 ]. Thus, the study and identification of peripheral and central candidate biomarkers may be helpful in disentangling the complexity of suicidal behaviors in order to implement adequate preventive strategies with reduced mortality of patients at high risk and less economic and societal burdens.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

C-Reactive Protein as a Potential Peripheral Biomarker for High-Lethality Suicide Attempts

Aguglia

Natale

Fusar-Poli

et al. 2022

Life

View full text Add to dashboard Cite

The aim of the present study was to identify a cut-off of c-reactive protein (c-RP) potentially predictive of high-lethality suicide attempts (SA) in an inpatient psychiatric sample. After attempting suicide, subjects were admitted to the emergency ward of the IRCCS Ospedale Policlinico San Martino and later to the section of Psychiatry from 1st August 2013 to 31st July 2018. C-reactive protein was measured. The Area Under the Receiver Operating Characteristic (ROC_AUC) was used to assess the discriminative capacity of c-RP for high- vs. low-lethality SA, and a logistic regression was performed to detect the odds ratio, adjusted for age and sex. High-lethality suicide attempters were 133 (30.8%), while low-lethality suicide attempters were 299 (69.2%). The optimal cut-off threshold (and corresponding sensitivity and specificity values) for c-RP was 4.65 mg/L (68/71%). This cut-off corresponds to an AUC of 73.5%. An odds ratio of 4.70 was generated for current high-lethality SA after a logistic regression, adjusted for age and sex. Research on social and biological factors underlying the lethality of SA is crucial for a better understanding of this complex phenomenon. Identifying potential predictors of SA, especially those at high lethality, is essential to implement personalized preventive strategies.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

C-Reactive Protein as a Potential Peripheral Biomarker for High-Lethality Suicide Attempts

Aguglia

Natale

Fusar-Poli

et al. 2022

Life

View full text Add to dashboard Cite

show abstract

“…Previous studies have used the C-SSRS to assess the lethality in suicide attempts [ 43 ]. High lethality in suicide attempts can be considered a close indicator of future completed suicide, and it is essential to study its neurobiology to elucidate the pathophysiology of suicide [ 44 ]. We recognize the importance of determining the lethality in suicide attempts in order to identify and refer patients to specialized care areas early and in a timely manner [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

High Serum Levels of IL-6 Are Associated with Suicide Attempt but Not with High Lethality Suicide Attempts: A Preliminary Case–Control Study

Castillo-Ávila

Genis‐Mendoza

Juárez‐Rojop

et al. 2022

IJERPH

View full text Add to dashboard Cite

Suicide attempts are an emerging health problem around the world. Increased levels of IL-6 have been associated with suicidal behavior. Therefore, the aims of this study were to evaluate the serum levels of IL-6 in individuals with suicide attempts and a comparison group and to associate the IL-6 levels with the lethality of the suicide attempt. Additionally, we associated the rs2228145 polymorphism of the IL6R gene with suicide attempts or with the IL-6 serum levels. Suicide attempts and their lethality were evaluated using the Columbia Suicide Severity Rating Scale. The serum concentrations of IL-6 were measured by the ELISA technique in individuals with suicide attempts and then compared to a control group. The rs2228145 polymorphism of the IL6R gene was analyzed by real-time polymerase chain reaction. We found elevated serum levels of IL-6 in the suicide attempt group when compared to the control group (F = 10.37, p = 0.002). However, we found no differences of the IL-6 levels between high and low lethality. The IL6R gene polymorphism rs2479409 was not associated with suicide attempts. Our data suggest that IL-6 serum is increased in individuals with suicide attempts.

show abstract

The pathophysiology of high-lethality suicide attempts: a vital area of suicide research

Cited by 2 publications

References 14 publications

C-Reactive Protein as a Potential Peripheral Biomarker for High-Lethality Suicide Attempts

C-Reactive Protein as a Potential Peripheral Biomarker for High-Lethality Suicide Attempts

High Serum Levels of IL-6 Are Associated with Suicide Attempt but Not with High Lethality Suicide Attempts: A Preliminary Case–Control Study

Contact Info

Product

Resources

About