The potential of brain stimulation techniques for substance use disorder treatment

Webber, Heather E.; Schmitz, Joy M.

doi:10.1590/1516-4446-2021-0040

Cited by 4 publications

(2 citation statements)

References 8 publications

(5 reference statements)

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“…It is also unknown if EEG can be directly targeted to alter SUD symptoms. Novel research utilizing brain stimulation techniques such as transcranial magnetic stimulation suggests that this might be possible (Webber & Schmitz, 2022). For example, stimulation to the prefrontal cortex has been shown to alter the amplitude of both the RewP and ERN (Baker et al., 2017, 2020; Rollnik et al., 2004; Ryan et al., 2022) and specifically increase the RewP in substance users (Biernacki et al., 2020).…”

Section: Discussionmentioning

confidence: 99%

A meta‐analysis of electrophysiological biomarkers of reward and error monitoring in substance misuse

Webber,

de Dios,

Kessler

et al. 2024

Psychophysiology

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Substance use disorders are characterized by marked changes in reward and error processing. The primary objective of this meta‐analysis was to estimate effect sizes for the reward positivity (RewP) and error‐related negativity (ERN), two event‐related potential indicators of outcome monitoring, in substance users compared to controls. The secondary objective was to test for moderation by demographic, substance type, and EEG experiment parameters. Final PubMed searches were performed in August 2023. Inclusion criteria were substance use disorder/dependence or validated self‐report of substance misuse, RewP/ERN means available, healthy control comparison group, non‐acute drug study, peer‐reviewed journal, English language, and human participants. Selection bias was tested through modified Egger's regression and exploratory 3‐parameter selection model tests. The RewP results (19 studies, 1641 participants) did not support an overall effect (Hedges' g = 0.07, 95% CI [−0.44, 0.58], p = .777) and nor effect of any moderators. The ERN results (20 studies, 1022 participants) indicated no significant overall effect (g = 0.41, 95%CI [−0.05, 0.88]). Subgroup analyses indicated that cocaine users had a blunted ERN compared to controls (g = 1.12, 95%CI [0.77, 1.47]). There was limited evidence for publication/small study bias. Although the results indicate a potential dissociation between substance types, this meta‐analysis revealed the need for additional research on the RewP/ERN in substance using populations and for better designed experiments that adequately address research questions.

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Section: Discussionmentioning

confidence: 99%

A meta‐analysis of electrophysiological biomarkers of reward and error monitoring in substance misuse

Webber,

de Dios,

Kessler

et al. 2024

Psychophysiology

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“…One of those strategies is the stimulation of brain tissue through tDCS to enhance activation of speci c brain regions. The neural substrates involved in addiction could be directly in uenced by this brain stimulation method [ 31 ]. Although several studies showed increased cognitive functions, such as memory or language [ 7 , 3 , 32 ], research so far has shown contradicting evidence to whether tDCS could effectively affect brain functioning to improve WM [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of prefrontal tDCS on working memory performance in chronic alcohol and tobacco use

Göttgens,

Habel¹,

Wallheinke

et al. 2023

Preprint

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Deficits in working memory (WM) are observable in a wide range of those psychiatric disorders associated with decreased activation of the prefrontal cortex. Given that WM is a crucial process supporting various cognitive functions, deficits interfere with daily life tasks and psychiatric treatment. The present study examines the influence of prefrontal brain stimulation on WM performance in alcohol-dependent patients (AD), tobacco users (TU) and healthy controls (HC). In a double-blind, sham-controlled study, transcranial direct current stimulation (tDCS) was applied to upregulate right dorsolateral prefrontal cortex (DLPFC) activity. Participants received anodal tDCS with current at an intensity of 1.5 mA for 20 minutes in the active group. A large reference electrode (10x10cm) was chosen to minimize stimulation effects and situated over the bilateral supraorbital area. While being stimulated, participants performed the n-back task as a measure of WM performance. Results revealed no significant differences in WM performance between active and sham stimulated participants. Further, performance in the AD group did not differ from TU and HC. According to previous research, stimulation the left DLPFC may more effective in enhancing WM performance. Our findings suggest that the use of larger reference electrodes can minimize the impact on underlying brain regions.

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Can Different Types of Acute Physical Exercise at Moderate Intensity Influence the Inhibitory Control and Craving Levels in Individuals with Substance Use Disorder?

Malagodi,

Greguol,

Tavares

et al. 2024

Journal of Drug Issues

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Substance use disorder (SUD) is recognized as a serious public health problem, leading to long-term neurological impairments that interfere with cognitive function. The purpose of this study was to verify the acute influence of two types of physical exercises on the inhibitory control (IC) and craving level in individuals with SUD. For this, 43 individuals underwent two physical exercise sessions (aerobic and functional) and a control session. Before and after each session, the individuals answered a questionnaire about their level of craving and inhibitory control was analyzed using the Go-NoGo protocol. Generalized estimating equations were used to assess the effect of timing and session on the variables. Significant improvements were observed in the IC and in the craving level after both physical exercise sessions when compared to the control session. It was found that both sessions of moderate physical exercise can be beneficial alternatives for individuals undergoing treatment for SUD.

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The potential of brain stimulation techniques for substance use disorder treatment

Abstract: How to cite this article: Webber HE, Schmitz JM. The potential of brain stimulation techniques for substance use disorder treatment.

Cited by 4 publications

References 8 publications

A meta‐analysis of electrophysiological biomarkers of reward and error monitoring in substance misuse

A meta‐analysis of electrophysiological biomarkers of reward and error monitoring in substance misuse

Effects of prefrontal tDCS on working memory performance in chronic alcohol and tobacco use

Can Different Types of Acute Physical Exercise at Moderate Intensity Influence the Inhibitory Control and Craving Levels in Individuals with Substance Use Disorder?

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