Polygenic risk scores and their potential clinical use in psychiatry: are we there yet?

Fries, Gabriel R.

doi:10.1590/1516-4446-2020-0865

Braz. J. Psychiatry

2020

DOI: 10.1590/1516-4446-2020-0865

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Polygenic risk scores and their potential clinical use in psychiatry: are we there yet?

Gabriel R. Fries

Abstract: How to cite this article: Fries GR. Polygenic risk scores and their potential clinical use in psychiatry: are we there yet? Braz J Psychiatry. 2020;00:000-000. http://dx.

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2023

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Cited by 2 publications

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Averaged versus individualized: pragmatic N-of-1 design as a method to investigate individual treatment response

Serpico,

Maziarz

2023

Euro Jnl Phil Sci

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Heterogeneous treatment effects represent a major issue for medicine as they undermine reliable inference and clinical decision-making. To overcome the issue, the current vision of precision and personalized medicine acknowledges the need to control individual variability in response to treatment. In this paper, we argue that gene-treatment-environment interactions (G × T × E) undermine inferences about individual treatment effects from the results of both genomics-based methodologies—such as genome-wide association studies (GWAS) and genome-wide interaction studies (GWIS)—and randomized controlled trials (RCTs). Then, we argue that N-of-1 trials can be a solution to overcome difficulties in handling individual variability in treatment response. Although this type of trial has been suggested as a promising strategy to assess individual treatment effects, it nonetheless has limitations that limit its use in everyday clinical practice. We analyze the existing variability within the designs of N-of-1 trials in terms of a continuum where each design prioritizes epistemic and pragmatic considerations. We then support wider use of the designs located at the pragmatic end of the explanatory-pragmatic continuum.

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Averaged versus individualized: pragmatic N-of-1 design as a method to investigate individual treatment response

Serpico,

Maziarz

2023

Euro Jnl Phil Sci

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A Wolf in Sheep's Clothing: Idealisations and the aims of polygenic scores

Serpico

2023

Studies in History and Philosophy of Science

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Polygenic risk scores and their potential clinical use in psychiatry: are we there yet?

Abstract: How to cite this article: Fries GR. Polygenic risk scores and their potential clinical use in psychiatry: are we there yet? Braz J Psychiatry. 2020;00:000-000. http://dx.

Cited by 2 publications

References 8 publications

Averaged versus individualized: pragmatic N-of-1 design as a method to investigate individual treatment response

Averaged versus individualized: pragmatic N-of-1 design as a method to investigate individual treatment response

A Wolf in Sheep's Clothing: Idealisations and the aims of polygenic scores

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