Melatonin decreases cocaine-induced locomotor activity in pinealectomized rats

Barbosa-Méndez, Susana; Salazar-Juárez, Alberto

doi:10.1590/1516-4446-2018-0400

Cited by 8 publications

(4 citation statements)

References 51 publications

(110 reference statements)

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“…Based on our findings, we would predict that females raised in Long photoperiod would exhibit more sign-tracking behavior than males or females raised in other photoperiods. Such studies would be especially pertinent as evidence suggests that substance use disorders show seasonality as well (Sandyk and Kanofsky, 1992;Sher, 2004;Morales-Muñoz et al, 2017;Barbosa-Méndez and Salazar-Juárez, 2020).…”

Section: Long Photoperiod Enhances Dat Inhibition In Femalesmentioning

confidence: 99%

Photoperiod Impacts Nucleus Accumbens Dopamine Dynamics

Jameson

Siemann

Melchior

et al. 2023

eNeuro

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Circadian photoperiod, or day length, changes with the seasons and influences behavior to allow animals to adapt to their environment. Photoperiod is also associated with seasonal rhythms of affective state, as evidenced by seasonality of several neuropsychiatric disorders. Interestingly, seasonality tends to be more prevalent in women for affective disorders such as Major Depressive Disorder and Bipolar Disorder. However, the underlying neurobiological processes contributing to sex-linked seasonality of affective behaviors are largely unknown. Mesolimbic dopamine input to the nucleus accumbens (NAc) contributes to the regulation of affective state and behaviors. Additionally, sex differences in the mesolimbic dopamine pathway are well-established. Therefore, we hypothesize that photoperiod may drive differential modulation of NAc dopamine in males and females. Here, we used fast-scan cyclic-voltammetry (FSCV) to explore whether photoperiod can modulate sub-second dopamine signaling dynamics in the NAc core of male and female mice raised in seasonally relevant photoperiods. We found that photoperiod modulates dopamine signaling in the NAc core, and that this effect is sex-specific to females. Both release and uptake of dopamine were enhanced in the NAc core of female mice raised in long, summer-like photoperiods, whereas we did not find photoperiodic effects on NAc core dopamine in males. These findings uncover a potential neural circuit basis for sex-linked seasonality in affective behaviors.Significance StatementDay length, or photoperiod, is a reliable indicator of the changing seasons, and is a powerful environmental cue influencing affective state and behavior. While studies have shown that photoperiod can modulate neurotransmitter systems involved in affective behavior, like the dopamine system, there are few studies examining effects of photoperiod on the synaptic level. Here we assess mesolimbic dopamine dynamics in mice maintained in seasonal photoperiods. We found a sex-specific effect wherein photoperiod modulates dopamine release from and uptake in dopaminergic terminals in the nucleus accumbens core of female mice with long summer-like photoperiods increasing dopamine release, thus uncovering a potential synaptic basis for sex-linked seasonality in affective behaviors.

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Section: Long Photoperiod Enhances Dat Inhibition In Femalesmentioning

confidence: 99%

Photoperiod Impacts Nucleus Accumbens Dopamine Dynamics

Jameson

Siemann

Melchior

et al. 2023

eNeuro

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“…Many studies have also claimed that melatonin has a strong neuroprotective effect against glutamate-induced excitotoxicity (Espinar et al, 2000 ; Lima et al, 2003 ; Vishnoi et al, 2016 ). Recently, melatonin has been shown to attenuate the rewarding behavior associated with many drugs of abuse such as cocaine (Sircar, 2000 ; Barbosa-Mendez and Salazar-Juarez, 2020 ) and alcohol (Vengeliene et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Melatonin Blocks Morphine-Induced Place Preference: Involvement of GLT-1, NF-κB, BDNF, and CREB in the Nucleus Accumbens

Alghamdi

Alshehri

2021

Front. Behav. Neurosci.

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Opioid addiction remains a widespread issue despite continuous attempts by the FDA to help maintain abstinence. Melatonin is a neurohormone considered to be involved only in the neuroendocrine and reproductive systems; however, recent reports have demonstrated its potential to attenuate drug addiction and dependence. Cumulative studies have suggested that melatonin can attenuate the rewarding effects of several drugs of abuse, including opioids. This study aimed to investigate the effect of melatonin (50 mg/kg) on morphine (5 mg/kg) to produce place preference. We also investigated the effect of melatonin and morphine on the expression of GLT-1, BDNF, NF-κB, and CREB within the nucleus accumbens. Male Wistar rats were divided into control, morphine, melatonin, and the morphine + melatonin groups. The study involved a two-phase habituation phase from day 1 to day 3 and an acquisition phase from day 5 to day 14. The conditioned place preference (CPP) score, distance traveled, resting time, ambulatory count, and total activity count were measured for all animals. Rats that received morphine showed a significant increase in CPP score compared to those in the control group. Morphine treatment reduced the mRNA expression of GLT-1, BDNF, and CREB and increased that of NF-κB. However, melatonin treatment administered 30 min before morphine treatment attenuated morphine place preference and reversed GLT-1, BDNF, NF-κB, and CREB expression levels. In conclusion, the study results indicate, for the first time, the new potential targets of melatonin in modulating morphine-induced CPP.

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“…The inhibitory action of melatonin on enhanced dopamine release was first demonstrated in excised female rat hypothalamic tissue in vitro, and it appears to be mediated by membranal, low-affinity melatonin binding sites by suppression of calcium influx into the stimulated nerve endings 77 . Melatonin inhibits dopamine release in the retina and mesencephalic dopamine areas 78 . It was reported that melatonin enhanced norepinephrine content in the adrenal medulla of chronically stressed rats 79 .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2021

IJPSR

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Melatonin decreases cocaine-induced locomotor activity in pinealectomized rats

Cited by 8 publications

References 51 publications

Photoperiod Impacts Nucleus Accumbens Dopamine Dynamics

Photoperiod Impacts Nucleus Accumbens Dopamine Dynamics

Melatonin Blocks Morphine-Induced Place Preference: Involvement of GLT-1, NF-κB, BDNF, and CREB in the Nucleus Accumbens

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