Life-threatening hypoglycemia attributable to haloperidol in a patient with schizophrenia

Couto, Joana; Santos, Luís Pontes dos; Mendes, Tiago; López, Raquel

doi:10.1590/1516-4446-2018-0356

Cited by 5 publications

(2 citation statements)

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“…To the best of our knowledge, there are no reports on clozapine‐induced hypoglycemia, but there are case reports of the development of hypoglycemia with other antipsychotics 4–13 (Table 1). Most patients develop hypoglycemia induced by second‐generation antipsychotics, with olanzapine and quetiapine being the most frequent.…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, there are no reports on clozapine-induced hypoglycemia, but there are case reports of the development of hypoglycemia with other antipsychotics [4][5][6][7][8][9][10][11][12][13] (Table 1). Most patients develop hypoglycemia induced by The treatment of impaired glucose tolerance includes diet, exercise, and oral hypoglycemic medications.…”

Section: Melkersson Et Al Suggested That the Putative Mechanism Of Cl...mentioning

confidence: 99%

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Recurrent reactive hypoglycemia due to clozapine‐induced glucose intolerance: A case report

Kawai,

Watanabe,

Ebihara

et al. 2023

PCN Reports

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BackgroundAlthough diabetes is one of the most common side effects of clozapine, a medication for the treatment of schizophrenia, to the best of our knowledge no study exists on clozapine‐induced glucose intolerance or hypoglycemia in patients with schizophrenia.Case PresentationWe report a case of schizophrenia with repeated reactive hypoglycemia due to abnormal glucose tolerance during clozapine treatment. During clozapine administration in patients with schizophrenia, it is necessary to monitor physical and psychiatric symptoms due to reactive hypoglycemia and hyperglycemia. If abnormal glucose tolerance is a concern, it should be promptly detected using blood or oral glucose tolerance tests.ConclusionEarly intervention for impaired glucose tolerance may prevent clozapine discontinuation due to diabetes or hyperglycemia.

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Section: Discussionmentioning

confidence: 99%