Metabolic syndrome and psychiatric disorders: a population-based study

Abstract

Objective:To identify the association of metabolic syndrome (MetS) and psychiatric disorders in young adults in southern Brazil.Methods:This population based cross-sectional study involved a total of 1,023 young adults between the ages of 21 and 32 years. Current episodes of psychiatric disorders were assessed using the Mini International Neuropsychiatric Interview – Plus version. MetS was evaluated using the National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III).Results:Of the 1,023 participants, 24.3% were identified with MetS, 13.5% were diagnosed with anxiety disorders, 7.5% with current depression, 3.9% with bipolar disorders and 10.1% were at risk of suicide. MetS was associated with ethnicity (p = 0.022), excess weight (p < 0.001), current anxiety disorders (p < 0.001), current mood disorders (bipolar disorder in mood episode and current depression) (p < 0.001), and suicide risk (p < 0.001).Conclusions:MetS was associated with psychiatric disorders. Awareness of factors associated with MetS can help identify high-risk individuals and stimulate disease prevention and control programs, as well as lifestyle changes.

Prevalência da Síndrome Metabólica e seus componentes na população adulta brasileira

“…Another relevant aspect of this study was the higher prevalence of MetS among women, corroborating findings from other studies 24,25 . Women had a higher prevalence in four of the five components, except for blood pressure, considered a more prevalent condition among men 36 globally.…”

“…It is also noteworthy that the most prevalent factor was high WC -significant abdominal obesity and metabolic deterioration marker 22,23 , commonly used in population studies 1,11,12 , followed by low HDL cholesterol, a significant predictor of cardiovascular risk 4 . MetS prevalence in this study was higher than that found in populations in other Latin American countries, such as in Colombia, Venezuela, Peru, and Mexico 5 , and in the Asia-Pacific region 24 , and higher than that found in local studies with specific populations at the national level, such as one study with adults in southern Brazil (24.3%) 25 , with the quilombola population (25.8%) 26 and the rural population (14.9%) 13 . Our findings also show a higher magnitude than previous studies with representative samples of the Brazilian population 10,11 .…”

Metabolic syndrome and associated factors among severely ill psychiatric and non-psychiatric patients: a comparative cross-sectional study in Eastern Ethiopia

“…The overall prevalence of metabolic syndrome among psychiatric patients in the current study was (35.6%) comparable with different studies: 28.9% at Jimma University Medical Center, Ethiopia [ 21 ], 34.74% in Kashmir [ 29 ] and 43.6% in Palestine [ 30 ]. However, the prevalence estimated in the present study was much higher than in studies conducted in Hawassa, 24.5% [ 31 ], 23.51% in Uganda [ 15 ], and 24.3% in Brazil [ 32 ]. The possible difference could be due to differences in types or generation of antipsychotic agents used by the patients (in our study, most of the patients used first-generation antipsychotics at the time of study), period of study, patients’ lifestyle, patterns of psychiatric illness (in our study, patients with severe psychiatric disorder were considered), duration of psychiatric illness, and sociocultural differences [ 33 – 35 ].…”

The prevalence and related factors of metabolic syndrome in outpatients with first-episode drug-naive major depression comorbid with anxiety

“…For example, an animal study showed that a diet rich in saturated fatty acids and fructose caused metabolic disturbances, triggering anxiety and depression-like behaviors in rats 27 . Other studies found that anxiety, depression, suicide attempts, and elevated thyrotropin caused obesity, increased blood lipids, increased blood glucose, higher body mass index (BMI), elevated blood pressure and other metabolic abnormalities 28 – 30 . Unfortunately, the relationship between these MetS risk factors and patients with depression and anxiety has not been systematically reported.…”