Vortioxetine-induced manic mood switch in patient with previously unknown bipolar disorder

An institutional review of dental orthopantomograms in patients receiving electroconvulsive therapy

“…Available meta-analyses showed no risk of vortioxetine-related AIHM, but four cases are reported in bipolar disorder (BD) and recurrent major depressive disorder (MDD). [2][3][4][5] We describe a case of an AIHM induced by vortioxetine in an 82-year-old male patient with recurrent MDD. He suffered from chronic atrial fibrillation, arterial hypertension and prostate benign hyperplasia.…”

“…This is the first description of a geriatric patient who developed AIHM with vortioxetine. Three more cases are reported: a 26-year-old woman with BD (with prior AIHM with sertraline) who was receiving lithium and lamotrigine 4 ; a 41-year-old male with recurrent MDD and a family history of puerperal psychosis 5 ; and a 58-yearold female with recurrent MDD with no prior history of AIHM or family history of psychiatric disorders. 2 One additional mention is made of a hypomanic episode (1/3018 patients) associated with vortioxetine in a pooled analysis of data from 11 randomized controlled trials in MDD.…”

Hypomanic switch during vortioxetine treatment: a case report

“…Vortioxetine is a novel antidepressant that has been reported to provide improvements in symptoms of depression and cognitive functions [11]. Nevertheless, there are two case reports describing vortioxetineinduced manic switch in the literature [12,13]; however, there are insufficient data on the risk of hypomanic/manic switch [14,15]. The aim of this case report was to present a case of hypomania induced during vortioxetine use in a patient who had received selective serotonin reuptake inhibitors (SSRIs) and venlafaxine several times in the past for the treatment of recurrent depression.…”

Vortioxetine treatment-emergent mania in the elderly: a case report

“…Available meta-analyses showed no risk of vortioxetine-related AIHM, but four cases are reported in bipolar disorder (BD) and recurrent major depressive disorder (MDD). 2 –5…”

“…This is the first description of a geriatric patient who developed AIHM with vortioxetine. Three more cases are reported: a 26-year-old woman with BD (with prior AIHM with sertraline) who was receiving lithium and lamotrigine4; a 41-year-old male with recurrent MDD and a family history of puerperal psychosis 5 ; and a 58-year-old female with recurrent MDD with no prior history of AIHM or family history of psychiatric disorders. 2 One additional mention is made of a hypomanic episode (1/3018 patients) associated with vortioxetine in a pooled analysis of data from 11 randomized controlled trials in MDD.…”