Organic psychosis due to hypoparathyroidism in an older adult: a case report

Dias-Amaral, Ana; Novais, C.; Coelho, Maria A.; Silva, Alzira; Curral, R.; Brandão, Isabel; Roma-Torres, António

doi:10.1590/1516-4446-2015-1869

Cited by 6 publications

(8 citation statements)

References 4 publications

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“…Ang et al concluded that unless Ca 2+ and Mg are normalized in patients with psychological problems, the treatment cannot be succeeded in the existence of hypocalcemia, hypercalcemia and hypomagnesemia [7].…”

Section: Discussionmentioning

confidence: 99%

“…A case report claimed that depressive condition and paresthesia of a 69year-old female patient with Gitelman Syndrome dramatically improved with intravenous magnesium sulfate treatment [29]. Ang et al reported that a patient showed psychological problems in cases of high-low calcium and low magnesium and the treatment could not be succeeded unless calcium and magnesium were normalized [7].…”

Section: Discussionmentioning

confidence: 99%

“…In a study considering calcium value, significantly calcium level in depression patient and bone mineral density was found to be significantly lower comparing to control group [6]. In another case report, it was mentioned that unless Ca and Mg are normalized in a patient with psychotic disorder, the treatment cannot be successful [7].…”

Section: Introductionmentioning

confidence: 98%

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Analysing Biochemical Parameters and Developing Risk Prediction Models in Patients with Schizophrenia and Bipolar Disorder

Kuzay

Polat

Konar

2021

EUROPEAN J MED ED TE

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Objectives: The aim of this study is to analyze biochemical parameters and develop risk prediction models in patients with schizophrenia and bipolar disorder.Methods: Biochemical values of 65 schizophrenia and 65 bipolar disorder patients were statistically compared by analyzing thyroid function tests (TSH, T3 and T4), 25-0H vitamin D3, calcium, ferritin, iron, folate, vitamin B12, and magnesium levels. Risk analysis of the control group was evaluated in line with the obtained findings.Results: Male patients diagnosed with schizophrenia were observed to have lower T3 level than that of control group (p<0.001). Vitamin B12 value and Ferritin levels of male patients diagnosed with bipolar disorder were higher than those of control group (p<0.05), while their T3 levels were lower comparing to control group (p<0.001). Female patients diagnosed with schizophrenia were observed to have higher Ferritin levels (p<0.05) and lower T3 levels comparing to control group (p<0.001). When female patients diagnosed with bipolar disorder were compared with control group, their Ferritin levels and T4 levels were observed to be higher (p<0.05). Conclusion:Unless an intervention is made by detecting vitamin deficiency, the treatment may fail with psychotropic medications. In psychotic symptoms, in addition to antipsychotic treatment, replacement of low serum vitamin level may have positive effects on recovery. Therefore, serum vitamin B12, T3, T4 and TSH hormones, and ferritin levels can be recommended to be used as routine screening tests especially in the first applications of psychiatric patients with cognitive disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Analysing Biochemical Parameters and Developing Risk Prediction Models in Patients with Schizophrenia and Bipolar Disorder

Kuzay

Polat

Konar

2021

EUROPEAN J MED ED TE

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“…A case report in 2016 discussed an aged man with organic psychosis due to deficient functioning of the parathyroid gland due to any therapeutic or diagnostic procedures (Iatrogenic) [ 35 ]. The report exemplified that a workup must be seen for psychosis if patients with psychiatric issues present atypically [ 35 ]. The symptoms can be hypoparathyroidism, low calcium levels, and brain calcifications [ 35 ].…”

Section: Reviewmentioning

confidence: 99%

“…The report exemplified that a workup must be seen for psychosis if patients with psychiatric issues present atypically [ 35 ]. The symptoms can be hypoparathyroidism, low calcium levels, and brain calcifications [ 35 ]. A case-control study quantified the concentrations of 25OHD3 in the CSF and serum of the patients with relapses of multiple sclerosis and observed no significant influence of 25OHD3 on CSF concentration [ 36 ].…”

Section: Reviewmentioning

confidence: 99%

A Review of the Relationship of the Cerebrospinal Fluid Changes During the Dysregulation of Parathyroid Hormone With Psychiatric or Neurological Manifestations

Kaleem

Alexander

Hisbulla

et al. 2021

Cureus

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It is established that normal calcium and vitamin D concentrations are maintained in the body through parathyroid hormone (PTH), a signaling molecule secreted from parathyroid glands. A massive role is played by PTH in increasing calcium levels when they are extremely low in the body through different mechanisms. The dysregulation of this hormone is due to either over functioning of the gland (hyperparathyroidism) or compromised functioning in hypoparathyroidism. A detailed review was done to identify if any changes are happening in the cerebrospinal fluid (CSF) due to any pathology causing the parathormone to be dysregulated enough to, in turn, cause any further pathology in the nervous system. This may then lead to various disabling neuropsychiatric features. The calcium and vitamin D abnormalities are both directly and indirectly connected to psychiatric features like delusions, schizophrenia, disabled cognition, psychosis, coma, mania, and depression of all kinds. Moreover, their irregularities are also linked to Alzheimer's. During these manifestations, the CSF is altered concentration-wise, where elevated calcium levels inside are observed during different studies. Despite PTH's indirect connection to the CSF modifications, their association hasn't been potently proven yet, considering more observational studies should be conducted in humans and for a more extended period, along with bigger and greater numbers of CSF samples. Suppose there is a possibility of the link of CSF alterations to PTH. In that case, we can consider a pronounced increase of CSF calcium or PTH as a risk factor for debilitating neuropsychiatric diseases. In this review, the possible correlation of CSF and PTH has been discussed.

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Epidemiology and Financial Burden of Adult Chronic Hypoparathyroidism

Björnsdóttir

Ing

Mitchell

et al. 2020

Journal of Bone and Mineral Research

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Chronic hypoparathyroidism is characterized by low serum calcium, increased serum phosphorus, and inappropriately low or decreased serum parathyroid hormone. This rare disorder is associated with a variety of complications. The prevalence, incidence, mortality, financial burden, and epidemiology of complications of this disorder are not well understood. This narrative review summarizes current information on the epidemiology and complications of chronic hypoparathyroidism. The reported prevalence of chronic hypoparathyroidism ranges from 6.4–37/100,000, and the incidence is reported to be 0.8–2.3/100,000/year. Mortality is not increased in studies from Denmark or South Korea but was increased in studies from Scotland and Sweden. The financial burden of this disorder is substantial because of increased health care resource utilization in two studies but not well quantitated. Recognized complications include hypercalciuria, nephrocalcinosis, kidney stones, and chronic kidney disease; low bone turnover and possibly upper extremity fractures; cardiac and vascular calcifications; basal ganglia calcifications, cataracts, infections, neuropsychiatric complications, and difficulties with pregnancy. This review concludes that chronic hypoparathyroidism is a rare disorder associated with significant morbidity that may not increase overall mortality but is associated with a substantial financial burden. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).

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Organic psychosis due to hypoparathyroidism in an older adult: a case report

Abstract: Impact of a behavioural sleep intervention on symptoms and sleep in children with attention deficit hyperactivity disorder, and parental mental health: randomised controlled trial. BMJ. 2015; 350:h68.

Cited by 6 publications

References 4 publications

Analysing Biochemical Parameters and Developing Risk Prediction Models in Patients with Schizophrenia and Bipolar Disorder

Analysing Biochemical Parameters and Developing Risk Prediction Models in Patients with Schizophrenia and Bipolar Disorder

A Review of the Relationship of the Cerebrospinal Fluid Changes During the Dysregulation of Parathyroid Hormone With Psychiatric or Neurological Manifestations

Epidemiology and Financial Burden of Adult Chronic Hypoparathyroidism

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