Thrombocytopenia with quetiapine: two case reports, one with positive rechallenge

Lalli, Alexandre; Michel, Bruno; Georget, S.; Bouillot, Catherine; Mangin, Anne; Javelot, Hervé

doi:10.1590/1516-4446-2015-1766

Cited by 4 publications

(2 citation statements)

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“…[30][31][32][33]), (2) adverse effects (e.g. [34][35][36][37][38][39]); in these two first sections, we described two cases in which clinical decisions were assisted by TDM [32,36]. "Pharmacopsy Alsace" is also involved in studies focusing on appropriate psychotropic use [40,41], the development of prescription support tools (anticholinergic impregnation scale for French psychiatry [42]) and training/information on psychotropic drugs [41,43].…”

Section: Contribution Of a New Partnership Approach Between Psychopha...mentioning

confidence: 99%

Enhancing the role played by clinical pharmacists in psychiatric settings to better integrate clinical psychopharmacology into the decision-making process

Javelot

Dizet²,

Straczek

et al. 2021

Therapies

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Section: Contribution Of a New Partnership Approach Between Psychopha...mentioning

confidence: 99%

Enhancing the role played by clinical pharmacists in psychiatric settings to better integrate clinical psychopharmacology into the decision-making process

Javelot

Dizet²,

Straczek

et al. 2021

Therapies

Self Cite

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“…Among the typical antipsychotic medications, the incidence of thrombocytopenia has been reported to be more with phenothiazines when compared to haloperidol. [3] Among the atypical antipsychotics, it is more often reported with clozapine,[456] although there are few case reports pointing to the association of olanzapine,[78910] risperidone,[1112] and quetiapine[131415] with thrombocytopenia.…”

Section: Introductionmentioning

confidence: 99%

Thrombocytopenia associated with olanzapine: A case report and review of literature

Sahoo

Singla

Spoorty

et al. 2016

Indian J Psychiatry

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There is limited literature on olanzapine-associated thrombocytopenia. In this report, we present a case of a 32-year-old female, suffering from persistent delusional disorder who had thrombocytopenia (46,000/mm3) with the use of olanzapine 25 mg/day, 6 weeks after starting medication. Blood film did not reveal any evidence of any dysplastic cells, disturbance in the count of other cell lines, and autoimmune workup including antinuclear antibodies and anti-neutrophil cytoplasmic antibodies were found to be negative. Given no other etiology, olanzapine was gradually tapered, and platelet counts were monitored. Reduction in the dose of olanzapine led to an improvement in platelet counts which reached the normal range after complete stoppage of olanzapine. In view of continued psychotic symptoms, she was started on clozapine and which was gradually increased to 200 mg/day with biweekly monitoring of total platelet counts before each increment in the dose of clozapine. Thrombocytopenia did not recur with use of clozapine. With clozapine, her psychosis improved by nearly 60%. A review of literature revealed only eight case reports supporting the association of olanzapine and thrombocytopenia.

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Quetiapine

2016

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Thrombocytopenia with quetiapine: two case reports, one with positive rechallenge

Cited by 4 publications

References 4 publications

Enhancing the role played by clinical pharmacists in psychiatric settings to better integrate clinical psychopharmacology into the decision-making process

Enhancing the role played by clinical pharmacists in psychiatric settings to better integrate clinical psychopharmacology into the decision-making process

Thrombocytopenia associated with olanzapine: A case report and review of literature

Quetiapine

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