Childhood trauma and dimensions of depression: a specific association with the cognitive domain

Vares, Edgar Arrua; Salum, Giovanni Abrahão; Spanemberg, Lucas; Caldieraro, Marco Antônio; Souza, Lívia Hartmann de; Borges, Roberta de Pádua; Fleck, Marcelo Pio de Almeida

doi:10.1590/1516-4446-2015-1764

Cited by 18 publications

(15 citation statements)

References 44 publications

(54 reference statements)

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“…Many studies have found childhood trauma to have robust negative impacts on clinical outcomes such as earlier age at onset, more severe type, more mood episodes, psychotic episodes, suicide attempts, mixed symptoms or episodes, comorbidity of substance abuse or dependence, and worse life functioning in mood disorder [12][13][14]. Our results also indicate that childhood trauma aggravates the severity of depression, which is consistent with previous findings [15,16]. In addition, childhood trauma has been reported to cause emotional dysregulation [15,17,18], as also found in the present study.…”

Section: Discussionsupporting

confidence: 91%

Chronotype Is Associated with Emotional Dysregulation Influenced by Childhood Trauma: A Retrospective Study

Park

2019

Chronobiol Med

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The aim of this study was to clarify the relationships among childhood trauma, emotional dysregulation, and circadian preference in patients with major depressive disorder (MDD). Methods: This study included 107 outpatients aged between 20 and 65 years who met the criteria of the fifth version of the Diagnostic and Statistical Manual of Mental Disorders for MDD on their medical records. The subjects were divided into morningness, intermediate, and eveningness groups according to their chronotype based on the Korean version of the Composite Scale of Morningness (K-CSM). All of the patients were evaluated using the Korean version of the Mood Disorder Questionnaire (K-MDQ) and the Beck Depression Inventory (BDI). Childhood traumatic events were evaluated using the Korean version of the Childhood Trauma Questionnaire (K-CTQ). Results: Comparing the demographic and clinical variables revealed that the mean age and the emotional abuse (EA), total BDI, and total K-MDQ scores differed significantly among the three groups. The total K-CSM score was negatively correlated with the total K-MDQ, K-CTQ, EA, and emotional neglect scores. The K-MDQ score was positively correlated with the total K-CTQ, EA, and PA scores. Linear regression analyses were performed to test whether childhood trauma was driving the association with emotional dysregulation (using K-MDQ), and whether emotional dysregulation was driving the association with eveningness (using K-CSM). Both higher EA and total BDI scores were independently associated with a higher K-MDQ score. A higher K-MDQ score was also independently associated with a lower K-CSM score (toward eveningness). Conclusion: The findings of this study support that childhood trauma influences emotional dysregulation, which in turn leads to a circadian preference toward eveningness. It can therefore be assumed that emotional dysregulation mediates the relationship between childhood trauma and eveningness.

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Section: Discussionsupporting

confidence: 91%

Chronotype Is Associated with Emotional Dysregulation Influenced by Childhood Trauma: A Retrospective Study

Park

2019

Chronobiol Med

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“…Suicide risk in the elderly was associated with physical and sexual abuse (Draper et al, 2008;Sachs-Ericsson et al, 2013). Indeed, most studies that focused on this link looked at adult populations (Bruwer et al, 2014;Jeon et al, 2014;Norman et al, 2012;Perales et al, 2012;Rajalin, Hirvikoski, & Jokinen, 2013;Tunnard et al, 2014;Vares et al, 2016). In a nationally representative sample of 55,299 respondents in 21 countries, childhood adversities were associated with an increased risk of lifetime suicide attempts and ideation.…”

Section: Childhood Maltreatment Suicide Riskmentioning

confidence: 99%

“…Among these, life events seem to be an important factor that generates geriatric depression (Donoghue et al, 2016). In addition, there may be a specific association between childhood trauma and the cognitive dimension of depression in adult life (associated with hopelessness, thoughts of death, suicidal thoughts, guilt, and self-punishment), which may explain the increased prevalence of late-life suicide risk (Vares et al, 2015(Vares et al, , 2016.…”

Section: Geriatric Depressionmentioning

confidence: 99%

Influence of childhood abuse and neglect subtypes on late-life suicide risk beyond depression

Jardim

Novelo

Spanemberg

et al. 2018

Child Abuse & Neglect

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The association of childhood maltreatment and suicide has been extensively examined within the population. Depression figures as a main cause for the elevated suicide rate in advanced ages and is often related to childhood maltreatment. The purpose of the present study was to examine the relationship between childhood maltreatment subtypes and suicide risk, testing geriatric depression as a moderator. This is a cross-sectional study looking at a sample of 449 individuals 60 year s old or older from the Multidimensional Study of the Elderly of Porto Alegre Family Health Strategy, Brazil (EMI-SUS/POA). Childhood maltreatment (Childhood Trauma Questionnaire), geriatric depressive symptoms (Geriatric Depression Scale), and suicide risk (Mini International Neuropsychiatric Interview) were assessed. The subtypes of childhood abuse and neglect were significantly associated with suicide risk. In the multivariate analysis, controlling for age, gender, income, marital status, ethnicity, smoking, and geriatric depression symptoms, all trauma subtypes remained associated with suicide risk with the exception of physical neglect (EA = 3.65; PA = 3.16; SA = 5.1; EN = 2.43; PN = 1.76). The present study showed that childhood maltreatment subtypes predicted suicide risk, and geriatric depression does not directly mediate this relation.

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“…It has been demonstrated that exposure to childhood trauma is often associated with poorer performance of executive function in patients with psychiatric disorders [ 4 ], individuals with ultra-high risk for psychosis [ 5 ], and even healthy school-aged children [ 6 ]. Moreover, a previous study has also revealed that childhood trauma may be specifically correlated with the subsequent development of cognitive symptoms of major depression [ 7 ]. Nevertheless, to date, the neural underpinnings of this consistently replicated relationship remain poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Neural correlates of childhood trauma with executive function in young healthy adults

Pan

Gao

et al. 2017

Oncotarget

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The aim of this study was to investigate the relationship among childhood trauma, executive impairments, and altered resting-state brain function in young healthy adults. Twenty four subjects with childhood trauma and 24 age- and gender-matched subjects without childhood trauma were recruited. Executive function was assessed by a series of validated test procedures. Localized brain activity was evaluated by fractional amplitude of low frequency fluctuation (fALFF) method and compared between two groups. Areas with altered fALFF were further selected as seeds in subsequent functional connectivity analysis. Correlations of fALFF and connectivity values with severity of childhood trauma and executive dysfunction were analyzed as well. Subjects with childhood trauma exhibited impaired executive function as assessed by Wisconsin Card Sorting Test and Stroop Color Word Test. Traumatic individuals also showed increased fALFF in the right precuneus and decreased fALFF in the right superior temporal gyrus. Significant correlations of specific childhood trauma severity with executive dysfunction and fALFF value in the right precuneus were found in the whole sample. In addition, individuals with childhood trauma also exhibited diminished precuneus-based connectivity in default mode network with left ventromedial prefrontal cortex, left orbitofrontal cortex, and right cerebellum. Decreased default mode network connectivity was also associated with childhood trauma severity and executive dysfunction. The present findings suggest that childhood trauma is associated with executive deficits and aberrant default mode network functions even in healthy adults. Moreover, this study demonstrates that executive dysfunction is related to disrupted default mode network connectivity.

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Childhood trauma and dimensions of depression: a specific association with the cognitive domain

Cited by 18 publications

References 44 publications

Chronotype Is Associated with Emotional Dysregulation Influenced by Childhood Trauma: A Retrospective Study

Chronotype Is Associated with Emotional Dysregulation Influenced by Childhood Trauma: A Retrospective Study

Influence of childhood abuse and neglect subtypes on late-life suicide risk beyond depression

Neural correlates of childhood trauma with executive function in young healthy adults

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