Neuroprogression and staging in psychiatry: historical considerations

Kapczinski, Flávio; Streb, Luis Guilherme

doi:10.1590/1516-4446-2014-3605

Cited by 13 publications

(12 citation statements)

References 4 publications

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“…This model proposes to explain the pathological brain rewiring that takes place in the context of severe mental disorders (Berk et al, 2011; Fries et al, 2012; Kapczinski and Streb, 2014), and links recurrent mood episodes with the disruption of the homeostasis between inflammatory mechanisms, oxidative processes, and neuroprotective mechanisms (e.g., BDNF). This disruption has been linked to an increase in the individual’s vulnerability to psychological stress, brain atrophy and ultimately cognitive impairment (Berk et al, 2010; Kapczinski et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Reduced hippocampus volume and memory performance in bipolar disorder patients carrying the BDNF val66met met allele

Cao

Bauer

Sharma

et al. 2016

Journal of Affective Disorders

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Background Previous studies investigated the impact of brain-derived neurotrophic factor (BDNF) val66met (rs6265) on hippocampus volumes and neurocognition in bipolar disorders (BD), but the results were not consistent. This study aimed to investigate the effect of BDNF polymorphism on hippocampus volumes and memory performance in well-characterized adult populations diagnosed with type I BD (BD-I) and major depressive disorder (MDD) compared with healthy controls (HC). Methods 48 BD-I patients, 33 MDD patients and 60 HC were genotyped for BDNF rs6265 using DNA isolated from white blood cells. Individuals with val/met and met/met genotypes were grouped as met carriers and compared to those with the val/val. Brain segmentations were obtained from structural magnetic resonance imaging (MRI) using the Freesurfer. Memory performance was assessed with the California Verbal Learning Task (CVLT). Results We found a significant diagnosis effect and marginal interaction between diagnosis and BDNF genotype group for both hippocampus volumes and memory performance. BDNF met allele carrier BD patients had smaller hippocampus volumes and reduced performance on multiple CVLT scores compared to MDD patients and HC. Conclusions We provide strong evidence for the BDNF val66met polymorphism as a putative biological signature for the neuroanatomical and cognitive abnormalities commonly observed in BD patients.

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Section: Discussionmentioning

confidence: 99%

Reduced hippocampus volume and memory performance in bipolar disorder patients carrying the BDNF val66met met allele

Cao

Bauer

Sharma

et al. 2016

Journal of Affective Disorders

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“…The presence of cognitive deterioration in elderly BD patients raises the question as to whether these impairments are age or illness-dependent. The neuroprogression model has been used to explain the pathological brain rewiring that takes place in the context of severe mental disorders [13][14][15]. This model links recurrent mood episodes with the disruption of the homeostasis between inflammatory mechanisms, oxidative processes, and neuroprotective mechanisms, such as BDNF, and eventually neuronal death (apoptosis).…”

Section: Introductionmentioning

confidence: 99%

Neuroprogression and Cognitive Functioning in Bipolar Disorder: A Systematic Review

Cardoso

Bauer

Meyer

et al. 2015

Curr Psychiatry Rep

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Bipolar disorder (BD) has been associated with impairments in a range of cognitive domains including attention, verbal learning, and mental flexibility. These deficits are increased during the acute phases of the illness and worsen over the course of BD. This review will examine the literature in relation to potential mechanisms associated with cognitive decline in BD. Scopus (all databases), Pubmed, and Ovid Medline were systematically searched with no language or year restrictions, up to January 2015, for human studies that collected cross-sectional and longitudinal cognitive data in adults with BD and matched healthy controls (HC). Selected search terms were "bipolar," "cognitive," "aging," "illness duration," "onset," and "progression." Thirty-nine studies satisfied the criteria for consideration. There is evidence that cognitive function in BD is negatively associated with features of illness progression such as number of mood episodes, illness duration, and hospitalizations. Aging does not appear to affect cognitive functioning to a greater extent than in HC. Furthermore, the small number of longitudinal studies in this field does not allow to reaching firm conclusion in terms of which sub-populations would be more prone to cognitive decline in BD. The decline in cognitive abilities over the course of the BD seems to be associated with the number of episodes and number of hospitalizations. No meaningful interaction of age and bipolar disorder has been found in terms of cognitive decline. Future large-scale longitudinal studies are necessary to confirm these findings and assist in the development of preventive interventions in vulnerable individuals.

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“…The concept of "neuroprogression" has been proposed to account for changes observed through the natural course of psychiatric disorders (Kapczinski et al, 2014). This concept finds its origins in Europe during the mid-19 th century, when Jean-Pierre Falret, Karl-Ludwig Kahlbaum and Joseph Guislain developed the idea of a longitudinal evolution of psychiatric disorders, even until recovery, and emphasized the importance of including longitudinal factors in psychiatric diagnosis.…”

Section: Neuroprogression and The Longitudinal Evolution Of Psychiatrmentioning

confidence: 99%

“…BD is a recurrent chronic disorder characterized by fluctuations in mood state and energy affecting more than 1% of the world's population (Grande et al, 2016). In BD, increased recurrences are associated with a risk of rapid cycling between the depressive and manic states (Berk et al, 2011a;Cramer et al, 2011;Kapczinski et al, 2014). This stepwise progression exists not only in clinical symptoms but also in treatment response, neurobiology, and functional impairment (Berk, 2009;McGorry et al, 2010McGorry et al, , 2006.…”

Section: Neuroprogression and The Longitudinal Evolution Of Psychiatrmentioning

confidence: 99%

The Plastic Adaptation to Pathology in Psychiatry. Are Patients with Psychiatric Disorders Pathological Experts?

Amad¹,

Expert²,

Lord³

et al. 2018

Preprint

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Psychiatric disorders share the same pattern of longitudinal evolution and have courses that tend to be chronic and recurrent. These aspects of chronicity and longitudinal evolution of psychiatric disorders are currently studied under the neuroprogression framework. Interestingly, considering the plasticity of the brain, it is necessary to emphasize the bidirectional nature of neuroprogression. We review evidence highlighting alterations of the brain associated with the longitudinal evolution of psychiatric disorders from the framework of neuroplastic adaptation to pathology. This new framework highlights that substantial plasticity and remodelling may occur beyond the classic neuroprogressive framework, which is characterized only by loss of grey matter volume, decreased brain connectivity, and chronic inflammation. We also integrate the brain economy concept in the neuroplastic adaptation to pathology framework, emphasizing that to preserve its economy, i.e., function, the brain learns how to cope with the disease by adapting its architecture. This approach can disentangle both the specific pathophysiology of psychiatric symptoms and the adaptation to pathology, thus offering a new framework for both diagnosis and treatment.

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Neuroprogression and staging in psychiatry: historical considerations

Cited by 13 publications

References 4 publications

Reduced hippocampus volume and memory performance in bipolar disorder patients carrying the BDNF val66met met allele

Reduced hippocampus volume and memory performance in bipolar disorder patients carrying the BDNF val66met met allele

Neuroprogression and Cognitive Functioning in Bipolar Disorder: A Systematic Review

The Plastic Adaptation to Pathology in Psychiatry. Are Patients with Psychiatric Disorders Pathological Experts?

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Neuroprogression and staging in psychiatry: historical considerations

Cited by 13 publications

References 4 publications

Reduced hippocampus volume and memory performance in bipolar disorder patients carrying the BDNF val66met met allele

Reduced hippocampus volume and memory performance in bipolar disorder patients carrying the BDNF val66met met allele

Neuroprogression and Cognitive Functioning in Bipolar Disorder: A Systematic Review

The Plastic Adaptation to Pathology in Psychiatry.&nbsp;Are Patients with Psychiatric Disorders Pathological Experts?

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The Plastic Adaptation to Pathology in Psychiatry. Are Patients with Psychiatric Disorders Pathological Experts?