Functional capacity: a new framework for the assessment of everyday functioning in schizophrenia

Mantovani, Lucas M.; Teixeira, Antônio Lúcio; Salgado, João Vinícius

doi:10.1590/1516-4446-2014-1551

Cited by 15 publications

(12 citation statements)

References 69 publications

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“…For adipometry and analysis of body circumferences, three measurements were performed at each site, with calculation of the arithmetic mean. 15,16 The percentage of body fat was calculated using Physical Test® software in order to analyze the gain or loss after the exercise program.…”

Section: Methodsmentioning

confidence: 99%

Increased flexibility, pain reduction and unaltered levels of IL-10 and CD11b + lymphocytes in patients with systemic lupus erythematosus were associated with kinesiotherapy

Timóteo

Silva

Micheli

et al. 2018

Lupus

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The effect of physical activity on the immune system is still poorly understood in cases of systemic lupus erythematosus (SLE). Therefore, our aim was to investigate differences in the serum levels of cytokines (IL-2, IL-5, IL-6, IL-8, IL-10 and TNF-α) and the numbers of CD11b + and CXCR2 + neutrophils and lymphocytes in women with SLE undergoing drug treatment, without ( n = 9) or with ( n = 5) 4 months of kinesiotherapy. Parameters related to functional capacity were also analyzed. In the case of the patients who were not submitted to kinesiotherapy, there were reductions in the levels of IL-5, IL-6 and IL-10, and an increase in the number of CD11b + leukocytes, in addition to an increase in abdominal circumference after the monitoring time. Patients submitted to kinesiotherapy did not present changes in serum cytokines or in the numbers of CD11b + and CXCR2 + neutrophils and lymphocytes, but there were increases of flexibility and strength, as well as a reduction in pain sensation after the monitoring time. In conclusion, kinesiotherapy was able to increase flexibility and reduce pain in SLE patients without influencing immune parameters.

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Section: Methodsmentioning

confidence: 99%

Increased flexibility, pain reduction and unaltered levels of IL-10 and CD11b + lymphocytes in patients with systemic lupus erythematosus were associated with kinesiotherapy

Timóteo

Silva

Micheli

et al. 2018

Lupus

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“…Difficulties in reliably and cost-effectively assessing every day community functioning in this population, and the negligible chance of attaining significant functional milestones such as marriage and employment within narrow time frames have generated considerable difficulties in measuring functional outcomes in short-term intervention studies in schizophrenia (Harvey et al, 2012; Mausbach et al, 2009; Moore et al, 2007). Hence, many researchers have advocated and implemented the use of functional capacity measures such as the University of California San Diego Performance-Based Skills Assessment (UPSA) (Patterson et al, 2001), its brief version UPSA-B (Mausbach et al, 2011) and Test of Adaptive Behaviour in Schizophrenia (TAB) (Velligan et al, 2007) as proxy measures of community functioning in research evaluating functional outcomes in schizophrenia (Mantovani et al, 2015; Patterson and Mausbach, 2010). Functional capacity can be defined as the skills and abilities people bring to execute a task in an optimal or standardised environment.…”

Section: Introductionmentioning

confidence: 99%

Limited changes in activities of daily life performance ability among people with schizophrenia at clinical settings and the factors moderating the changes

Ayres

Ngo

John

2019

Schizophrenia Research: Cognition

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BackgroundImpaired community functioning and functional ability are common among people with schizophrenia spectrum disorders (SSD). However, changes occurring in activities of daily life (ADL) ability through interventions provided at clinical settings have not been systematically examined in this population.MethodsWe retrospectively collated and analysed changes in ADL ability between admissions and discharges, measured utilising the Assessment of Motor and Process Skills (AMPS), among 72 people with SSD at a public inpatient treatment and rehabilitation facility in Western Australia. Clinical and demographic factors moderating the changes were also determined.ResultsThe standardised AMPS motor (p = 0.0088) and process scores (p < 0.0001) improved significantly between admission and discharge. However, overall, the improvements were of small to moderate magnitude, and >60% of participants did not experience significant or meaningful changes. Furthermore, mild to moderate impairment in the AMPS standardised motor (−1.3 SD), and process (−1.6 SD) ability was present at discharge. A logistic regression analysis revealed that low admission AMPS scores and duration of illness of more than five years predicted improvement of the AMPS motor score by discharge, but only the former predicted changes in the process scores. Other demographic, clinical, and treatment-related variables did not affect the outcome of the AMPS scores.ConclusionsImpairment of ADL ability is recalcitrant in schizophrenia. The improvement was modest and occurred only in a proportion of participants. However, promisingly, chronic illness, low baseline ADL ability, treatment with clozapine and presence of treatment-resistant schizophrenia did not have an adverse effect on the outcome.

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“…Detection of everyday functioning problems can vary depending on whether one utilizes measures of manifest everyday functioning (e.g., what one actually does in daily life) or measures of functional capacity (e.g., what one can do under ideal circumstances; Mantovani et al, 2015). Ideally, a clinical evaluation of everyday functioning would draw data from multiple sources including patient report, proxy-report, caregiver rating scales, and observations of behaviors in the real world, and should focus on both manifest functioning and functional capacity.…”

mentioning

confidence: 99%

Construct validity of the UCSD performance-based skills assessment-brief version (UPSA-B) in HIV disease

Sheppard

Woods

Verduzco

2017

Applied Neuropsychology: Adult

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Among individuals living with HIV disease, approximately 60% experience problems with everyday functioning. The present study investigated the utility of the UCSD Performance-based Skills Assessment-Brief Version (UPSA-B) as a measure of functional capacity in HIV. We utilized a cross-sectional three-group design comparing individuals with HIV- associated neurocognitive disorder (HAND) (HIV + HAND+; n = 27), HIV+ neurocognitively normal individuals (HIV + HAND-; n = 51), and an HIV- comparison group (HIV-; n = 28) with broadly comparable demographics and non-HIV comorbidities. Participants were administered the UPSA-B, the Medication Management Test-Revised (MMT-R), and were assessed for manifest everyday functioning and quality of life, as part of a standardized clinical neurocognitive research battery. Results indicated that the HIV + HAND+ group had significantly lower UPSA-B scores than the HIV + HAND-group, but did not differ from the HIV- group. Among HIV+ individuals, UPSA-B scores were significantly related to MMT-R scores, all neurocognitive domains assessed, and education, but the UPSA-B was not related to manifest everyday functioning (e.g., unemployment), health-related quality of life, or HIV disease variables. Findings provide mixed support for the construct validity of the UPSA-B in HIV. Individuals impaired on the UPSA-B may be at increased risk for HAND, but the extent to which it detects general manifest everyday functioning problems is uncertain.

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Functional capacity: a new framework for the assessment of everyday functioning in schizophrenia

Cited by 15 publications

References 69 publications

Increased flexibility, pain reduction and unaltered levels of IL-10 and CD11b + lymphocytes in patients with systemic lupus erythematosus were associated with kinesiotherapy

Increased flexibility, pain reduction and unaltered levels of IL-10 and CD11b + lymphocytes in patients with systemic lupus erythematosus were associated with kinesiotherapy

Limited changes in activities of daily life performance ability among people with schizophrenia at clinical settings and the factors moderating the changes

Construct validity of the UCSD performance-based skills assessment-brief version (UPSA-B) in HIV disease

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