Marchiafava-Bignami disease as a cause of visual hallucinations

Augusto, Luís; Figueiredo, Rita; Costa, Henrique; Reis, Carina; Silva, Maria Luís

doi:10.1590/1516-4446-2014-1529

Cited by 4 publications

(2 citation statements)

References 3 publications

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“…On the other hand, corpus callosum degeneration has been observed in chronic alcoholics, even in the absence of malnutrition, and has been attributed to cortical and white matter atrophy [6,7]. Remarkably, in a previous report by Augusto et al, a 52-yearold female patient presenting with hallucinations and cognitive impairment was also reported at whom MRI revealed T2 hyperintense lesions in the corpus callosum that was similar to the lesion in our patient [8]. However, the authors preferred to describe this patient as Marchiafava-Bignami disease, rather than WE.…”

Section: Discussionsupporting

confidence: 78%

Dramatic Recovery of a Patient With Wernicke Encephalopathy Presenting With the Lesion of the Corpus Callosum

Önder

2020

J Neurol Res

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In this report, I present a rare patient of Wernicke encephalopathy (WE) with a callosal lesion on magnetic resonance imaging at whom a dramatic clinical recovery was achieved by parenteral thiamine therapy. Based on the presentation of this patient, first, I suggest that the awareness of WE among clinicians should be further increased. Second, I re-emphasize the importance of initiation of parenteral thiamine treatments in clinical suspicion of WE which may provide dramatic responses even in patients with atypical lesion sites as in our patient. Future reports including outcomes of a larger number of cases with distinct neuroimaging signs may provide a better understanding of the real clinical burden of the disease as well as unknown aspects of WE.

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Section: Discussionsupporting

confidence: 78%

Dramatic Recovery of a Patient With Wernicke Encephalopathy Presenting With the Lesion of the Corpus Callosum

Önder

2020

J Neurol Res

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“…[ 5 ] Augusto et al . [ 8 ] reported visual hallucinations in a 52-year-old woman with chronic alcoholism and MBD, and Hui et al . [ 9 ] described, in a 41-year-old man, persecutory delusion and auditory hallucinations which did not respond to 15 mg of haloperidol or 6 mg of risperidone.…”

Section: Discussionmentioning

confidence: 99%

Marchiafava-Bignami Disease Presenting as Acute Psychosis

Naaz¹,

Rizvi²,

Usmani

2018

Indian Journal of Psychological Medicine

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Thiamine deficiency, oxidative metabolic pathways and ethanol-induced neurotoxicity: how poor nutrition contributes to the alcoholic syndrome, as Marchiafava–Bignami disease

et al. 2017

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Ethanol is an important risk factor for the occurrence of several brain disorders that depend on the amount, period and frequency of its consumption. Chronic use of ethanol often leads to the development of neurodegenerative syndromes, which cause morphological and functional impairments such as foetal alcohol syndrome in newborns exposed to ethanol during pregnancy, Wernicke-Korsakoff Syndrome and, more rarely, Marchiafava-Bignami disease (MBD). MBD is characterized by primary degeneration of the corpus callosum, without inflammation and is associated with oxidative stress and hypovitaminosis, as well as altered mental status, to mention dementia, seizures, depression and so on. This review discusses MBD and poor nutrition as a risk factor for the development of such alcoholic syndrome, with focus on diagnosis, pathogenic aspects, signs and symptoms, as well as therapeutic perspectives. On the basis of the inclusion/exclusion criteria adopted, the performed search in scientific databases (Pubmed, Scielo and Google Scholar) resulted in 100 studies that are being presented and discussed in the present work. Review, case-control and cohort studies on alcoholism-associated hypovitaminosis, oxidative stress, MBD and ethanol metabolism pathways were admitted as relevant. We highlight that MBD is a poorly described, diagnosed, insidious and progressive condition, for which evidence suggests a synergism between ethanol-induced neurotoxic effects and hypovitaminosis B. Present treatment consists of vitamin B1(thiamine) supplementation. Nonetheless, other strategies such as the inclusion of antidepressants or steroidal anti-inflammatories as add-on therapies have been employed as an attempt to improve the damage. Indeed, both the diagnosis and treatment are difficult, and death occurs within few years.

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Marchiafava-Bignami disease as a cause of visual hallucinations

Cited by 4 publications

References 3 publications

Dramatic Recovery of a Patient With Wernicke Encephalopathy Presenting With the Lesion of the Corpus Callosum

Dramatic Recovery of a Patient With Wernicke Encephalopathy Presenting With the Lesion of the Corpus Callosum

Marchiafava-Bignami Disease Presenting as Acute Psychosis

Thiamine deficiency, oxidative metabolic pathways and ethanol-induced neurotoxicity: how poor nutrition contributes to the alcoholic syndrome, as Marchiafava–Bignami disease

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