“…1,2 A pioneering author who tried to earn a living through writing alone, Poe led a life of hardship and some professional unpleasantnesses. 1,2 This suffering always influenced his work and is present throughout his masterpieces, as he wrote in The Fall of the House of Usher: ''It was, he said, a constitutional and a family evil, and one for which he despaired to find a remedy.'' Bipolar affective disorder is characterized by high rates of morbidity and disability and may be misdiagnosed as major depressive disorder in some settings.…”