hTERT gene methylation in circulating DNA, tumor, and surrounding tissue in breast cancer: a prospective study
Luiz Fernando de Queiroz,
Marcelo Soares da Mota e Silva,
Heitor Siffert Pereira de Souza
et al.
Abstract:BACKGROUND:
The human telomerase reverse transcriptase (hTERT) enzyme, encoded by the
hTERT
gene, synthesizes protective telomeric sequences on chromosomes and plays a fundamental role in cancer formation. Methylation of the
hTERT
gene has an upregulatory effect, increasing hTERT enzyme synthesis and allowing continuous tumor cell division.
OBJECTIVE:
In a group of patients with breast cancer, we aimed to analyze the… Show more
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