Subclinical thyroid diseases as a non-classical risk factor for cardiovascular diseases

Lotufo, Paulo A.

doi:10.1590/1516-3180.2020.138230032020

Sao Paulo Med. J.

2020

DOI: 10.1590/1516-3180.2020.138230032020

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Subclinical thyroid diseases as a non-classical risk factor for cardiovascular diseases

Paulo A. Lotufo

Abstract: Cardiovascular diseases are the most common cause of death worldwide and in Brazil. [1][2][3] Although mortality caused by these diseases has been decreasing over the last few decades, the pace of this decrease has differed according to socioeconomic status. The decrease has been greater

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“…Dear Editor, I read with interest the editorial about subclinical thyroid disorders as a non-classical risk factor for cardiovascular disease. 1 Although the editorial discusses some particularly important issues regarding the epidemiology of cardiovascular diseases and points out that there is a high burden of underdiagnosed subclinical thyroid diseases, especially among women and individuals with low socioeconomic status, some remarks about this need to be made.…”

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Subclinical thyroid disorders should not be considered to be a non-classical risk factor for cardiovascular diseases

Olmos

2021

Sao Paulo Med. J.

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mentioning

confidence: 99%

Subclinical thyroid disorders should not be considered to be a non-classical risk factor for cardiovascular diseases

Olmos

2021

Sao Paulo Med. J.

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Associations between thyroid-stimulating hormone and hypertension according to thyroid cyst status in the general population: a cross-sectional study

Shimizu

Nabeshima-Kimura

Kawashiri

et al. 2020

Environ Health Prev Med

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Background The absence of thyroid cysts may indicate latent thyroid damage, as demonstrated in our previous study. However, the association between the absence of thyroid cysts and latent functional damage of the thyroid is unknown. At low thyroid hormone productivity, which may be associated with latent functional damage of the thyroid, the association between thyroid-stimulating hormone (TSH) and hypertension might be enhanced. Therefore, we evaluated the association between TSH level and hypertension stratified by thyroid cyst status. Methods We conducted a cross-sectional study of 1724 euthyroid Japanese individuals aged 40–74 years who participated in an annual health checkup in 2014. Results In the study population, 564 and 686 participants had thyroid cysts and hypertension, respectively. A significant positive association was observed between TSH and hypertension in subjects without a thyroid cyst but not in subjects with thyroid cysts. There was a significant positive association between hypertension and TSH in subjects without a thyroid cyst (odds ratio [OR] 1.27; 95% confidence intervals [CI] 1.01, 1.61) but not in subjects with thyroid cysts (OR 0.79; CI 0.57, 1.09) in the model fully adjusted for known confounding factors. The correlation between the TSH and free triiodothyronine (fee T3) levels (simple correlation coefficient [r] = − 0.13, p < 0.01) was stronger in the subjects without thyroid cysts than in those with thyroid cysts (r = − 0.03, p = 0.525). Conclusions TSH is positively associated with hypertension only in individuals without thyroid cysts. The correlation between the TSH and free T3 levels was stronger in the subjects without thyroid cysts than in those with thyroid cysts. Therefore, the absence of thyroid cysts could be related to the association between TSH level and hypertension, possibly by indicating that the subjects without thyroid cysts had limited thyroid hormone reserves. Therefore, the absence of thyroid cysts could indicate the latent functional damage of the thyroid.

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Subclinical thyroid diseases as a non-classical risk factor for cardiovascular diseases

Abstract: Cardiovascular diseases are the most common cause of death worldwide and in Brazil. [1][2][3] Although mortality caused by these diseases has been decreasing over the last few decades, the pace of this decrease has differed according to socioeconomic status. The decrease has been greater

Cited by 2 publications

References 21 publications

Subclinical thyroid disorders should not be considered to be a non-classical risk factor for cardiovascular diseases

Subclinical thyroid disorders should not be considered to be a non-classical risk factor for cardiovascular diseases

Associations between thyroid-stimulating hormone and hypertension according to thyroid cyst status in the general population: a cross-sectional study

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